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A kind of medicine, composition and preparation thereof for preventing or treating diabetes

A technology of diabetes and medicine, applied in the field of compositions and preparations, medicines for preventing or treating diabetes

Active Publication Date: 2019-02-22
THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there is no report on the treatment of diabetes with tervinetin

Method used

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  • A kind of medicine, composition and preparation thereof for preventing or treating diabetes
  • A kind of medicine, composition and preparation thereof for preventing or treating diabetes
  • A kind of medicine, composition and preparation thereof for preventing or treating diabetes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1: the hypoglycemic effect of teruciside

[0028] experimental method

[0029] In order to study the effect of espressoside on type II diabetes, the classic type II diabetes model was used in this experiment, and C57BL mice were randomly divided into 3 groups, normal control group (10 mice), model group (10 mice), special female The quincetin treatment group (10 animals), in which the model group and the espressoside treatment group were given a high-fat diet (basic feed with 20% lard) to establish the model for 8 weeks, and the tequitoside treatment group was given a high-fat diet and oral administration at the same time. The rats were given by gavage (50 mg / kg / d), fasted overnight after the administration, and measured fasting blood glucose, glucose tolerance and insulin tolerance.

[0030] Glucose tolerance test method: mice were fasted overnight, and after oral administration of 2 g / kg glucose, blood was collected from the tail tip to measure the corre...

Embodiment 2

[0054] Example 2: The synergistic hypoglycemic effect of privetin and glimepiride

[0055] Disorders of sugar intake are one of the main causes of diabetes. The inventors starved the hepatocytes for 6 hours, and then gave corresponding drug treatments, taking the uptake of glucose by hepatocytes as an indicator of drug efficacy. Glucose uptake was measured using the glucose uptake assay kit from Ai Meijie Technology Co., Ltd., and the measurement method was carried out according to the instructions. Based on the Median-effect Principle, the CombiDrug Statistical Combination Index (CI) is used to quantitatively evaluate the synergistic, antagonistic or additive relationship between the two drugs.

[0056] The specific steps are as follows: the drug effect (fa) is the glucose uptake rate, according to the middle-effect equation fa / fu=(D / Dm) m , take the logarithm logfa / fu=mlogD-mlogDm on both sides, set a=-mlogDm, b=m, x=logD, y=logfa / fu, and substitute it into the middle-ef...

Embodiment 3

[0060] Embodiment 3: formulation example

[0061] quintessence tablet

[0062] Special privet glycosides 10mg, starch 88g, magnesium stearate 3g.

[0063] Preparation process: take terugenin, add starch and magnesium stearate, mix evenly, make into granules, dry, and press into tablets.

[0064] Special privet glycosides capsules

[0065] Special privet glycosides 10mg, starch 88g, magnesium stearate 3g.

[0066] Preparation process: take quincetin, add starch, and magnesium stearate, mix evenly, make into granules, dry, and pack into capsules.

[0067] quinquefasin injection

[0068] Special privet glycosides 47mg, sodium chloride injection 7mg.

[0069] Preparation process: take teruzheng glycosides and add 1.9mL water for injection to dissolve, add sodium chloride for injection to isotonic, adjust the pH value to 7-7.1, filter, refrigerate for 24 hours, add water for injection to a specified amount, filter, Potting, sterilization, and that's it.

[0070] Tetraprive...

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PUM

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Abstract

The invention discloses a medicine for preventing or treating diabetes, a composition and a preparation thereof. The medicine for preventing or treating diabetes comprises an active component specnuezhenide and glimepiride, and also comprises a pharmaceutically acceptable carrier or an excipient to prepare a pharmaceutically acceptable dosage form. The specnuezhenide has effect for reducing blood glucose, can be used for preventing or treating diabetes, by combining with glimepiride, the effect is better, and specnuezhenide and glimepiride have obvious synergistic interaction.

Description

technical field [0001] The invention belongs to the field of medicine, relates to the discovery of a drug for preventing or treating diabetes, and in particular relates to a medicine, composition and preparation for preventing or treating diabetes. Background technique [0002] According to a report released by the World Health Organization on April 6, 2016, the number of people with diabetes in the world has exceeded 400 million, and most of them live in developing countries. That number is just 108 million, or about 4.7% of the global population. The incidence of diabetes in China has also exploded. Exceeding the ideal blood sugar increases the risk of cardiovascular disease and other diseases, making diabetes an important disease that threatens human health. In 2012, diabetes caused an estimated 1.5 million deaths worldwide. [0003] Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia. It is divided into type I and type II. The pathogenesi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61K31/64A61P3/10A23L33/00
CPCA23V2002/00A61K31/64A61K31/7048A61K2300/00A23V2200/328
Inventor 张基田鑫张晓坚梁艳杨志衡薛文华张丽珍常媛媛
Owner THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV