A kind of preparation method of linear polyethylene glycol-dendrimer poly(thioether-amine) block copolymer

Abstract

The invention relates to a preparation method of a linear polyethylene glycol-dendritic poly (thioether-amine) block copolymer. The preparation method is characterized by comprising the following steps: utilizing linear polyethylene glycol monomethyl ether to sequentially react with methacryloyl chloride (methacrylic anhydride), a sulphur amine compound and glycidyl methacrylate and preparing the linear polyethylene glycol-dendritic poly (thioether-amine) block copolymer through an end divergent synthesis method; repeating the above reaction steps and preparing linear-dendritic block copolymers with different algebras and molecular weights. In the linear-dendritic block copolymer prepared by the preparation method provided by the invention, a linear polyethylene glycol component is good in biological compatibility, a dendritic poly (thioether-amine) component contains hydroxyl, amino or methacrylate and other various reactive groups, the chemical composition and a molecular structure are definite, and a selective group is utilized for reaction, so that the integrated functional modification on pharmaceutical molecules, medical imaging probes and the like can be realized.

Description

technical field [0001] The invention relates to a preparation method of a linear polyethylene glycol-dendrimer poly(thioether-amine) block copolymer, belonging to the field of organic macromolecules. Background technique [0002] Dendritic macromolecules refer to macromolecules whose structure is similar to that of a tree, starting from the core and repeatedly branching outwards. The structure of dendrimers is generally spherical, but also elliptical and conical. At present, dendrimers have become a research hotspot in the field of polymer chemistry. Dendritic macromolecules have the following characteristics: 1. Regular, refined and highly symmetrical structure; 2. The volume, shape and functional groups of molecules can be precisely controlled; 3. Monodisperse molecular weight distribution; 4. High density of surface functional groups ;5. Spherical molecules are tight on the outside and loose on the inside, and the internal cavity can be adjusted. Therefore, it has uniq...

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Problems solved by technology

[0003] Linear-dendritic structure polymers refer to a class of artificially synthesized polymers that are connected to dendritic polymers at one or both ends of the linear polymers. This molecule combines linear segments with entangled molecular chains and dense dendritic Units are combined so that they have unique topological configurations and functionalities, especially in self-assembly. By regulating the length of the linear chain and the size, shape, chemical structure and surface functional groups of the dendritic unit, the linear Type-dendritic structure polymers can form assemblies of various shapes such as micelles, vesicles, fibers, and porous sheets, and exhibit stimuli responsiveness to light, pH, temperature, redox, and enzymes. Nowadays, Linear-dendritic copolymers have become a new type of building block for the preparation of various nano / micro-structured functional colloids, and have great potential application value in the fields of biomolecular diagnosis, drug / gene delivery, and tissue engineering scaffolds. However, limited Due to the limitation of synthetic methods, most of the current linear-dendritic polymers have many synthesis steps, long time and high cost, and the preparation of monodisperse, high-algebra linear-dendritic polymers is still a challenge. Therefore, exploring The synthesis method and functionalization of linear-dendritic polymers have important research value and significance.

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