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Drug delivery system by gelatin sponge or gelatin microsphere and drug delivery system prepared thereby

A gelatin and drug technology, which can be used in application, drug combination, drug formulation and other directions, and can solve the problems of irregular particle shape and porous size damage of embolic agents.

Inactive Publication Date: 2017-03-22
HJ医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The technical problem to be solved by the present invention is to overcome the defect that the existing gelatin sponge exists and then refrigerated and dried, which will cause damage to the porous size and even the irregular shape of the embolic agent particles caused by crushing, and provides a gelatin drug carrier, a gelatin particle embolic agent and its preparation Methods and Applications

Method used

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  • Drug delivery system by gelatin sponge or gelatin microsphere and drug delivery system prepared thereby
  • Drug delivery system by gelatin sponge or gelatin microsphere and drug delivery system prepared thereby
  • Drug delivery system by gelatin sponge or gelatin microsphere and drug delivery system prepared thereby

Examples

Experimental program
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Effect test

Embodiment 1

[0076] A gelatin drug carrier, its preparation flow chart is as follows figure 2 As shown, the specific preparation method is as follows:

[0077] (1) Gelatin solution forming process: put the gelatin into 100mL of water, soak for 30 minutes and heat and stir until the gelatin dissolves, and then cool down to 40°C to obtain a gelatin solution with a concentration of 4% (w / v);

[0078] (2) Gelatin styrofoam formation process: Add 0.5mg / mL formaldehyde to the obtained gelatin solution, and stir at a speed of 1400-1500rpm for 15-30 seconds to solidify the gelatin solution to form a cross-linked structure state gelatin foam;

[0079] (3) Centrifugal separation process: utilize acetone to clean the obtained gelatin styrofoam, and then utilize a centrifugal separator to carry out centrifugal separation;

[0080] (4) Gelatin styrofoam processing procedure: Add the gelatin styrofoam after centrifugation to phosphate buffered saline with a pH of 8 and a concentration of 12.5 mM, and...

Embodiment 2

[0086] A gelatin drug carrier, its preparation flow chart is as follows figure 2 As shown, the specific preparation method is as follows:

[0087] (1) Gelatin solution forming process: put the gelatin into 100mL of water, soak for 30 minutes, heat and stir until the gelatin dissolves, and then cool down to 40°C to obtain a gelatin solution with a concentration of 5% (w / v);

[0088] (2) Gelatin styrofoam formation process: Add 0.3 mg / mL formaldehyde to the obtained gelatin solution, and stir at a speed of 1400-1500 rpm for 15-30 seconds to solidify the gelatin solution to form a cross-linked structure state gelatin foam;

[0089] (3) Centrifugal separation process: utilize distilled water to clean the obtained gelatin foam, and then utilize a centrifugal separator to carry out centrifugal separation;

[0090] (4) Gelatin styrofoam processing procedure: Add the gelatin styrofoam after centrifugation to a phosphate buffer solution with a pH of 8 and a concentration of 25mM, an...

Embodiment 3

[0096] A gelatin drug carrier, its preparation flow chart is as follows figure 2 As shown, the specific preparation method is as follows:

[0097] (1) Gelatin solution forming process: put the gelatin into 100mL of water, soak for 30 minutes, heat and stir until the gelatin dissolves, and then cool down to 40°C to obtain a gelatin solution with a concentration of 1% (w / v);

[0098] (2) Gelatin foaming gel forming process: Add formaldehyde at a concentration of 0.1 mg / mL to the obtained gelatin solution, and stir at a speed of 500 to 1000 rpm to solidify the gelatin solution to form a cross-linked gelatin foam. Foam;

[0099] (3) Centrifugal separation process: utilize acetone to clean the obtained gelatin styrofoam, and then utilize a centrifugal separator to carry out centrifugal separation;

[0100] (4) Gelatin foam processing procedure: Add the gelatin foam after centrifugation to the Tris buffer solution with a pH of 8 and a concentration of 12.5mM, and keep the pH abov...

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Abstract

The present invention discloses a method for preparing gelatin sponge or gelatin microspheres containing phosphate buffered saline (PBS) or phosphate buffer and is directed to improve the conventional process having problems of difficulty in controlling shapes caused by the collapse of pores during a refreezing process and irregular and non-uniform shapes of embolic agent granules during pulverization. The present invention relates to a method for preparing a gelatin-based drug delivery system that allows higher stability and shape retainability by setting detailed conditions in a series of processes to obtain desired gelatin foam and an additional process suggesting a post-treatment process for the thus obtained gelatin foam, as well as a gelatin-based drug delivery system obtained by the method. The gelatin-based drug delivery system is obtained by adding phosphate buffered saline or phosphate buffer to crosslinked gelatin foam, drying the foam while maintaining pH in a range from neutral pH to alkaline pH, and inducing ionic bonding with a liver cancer-treating agent.

Description

technical field [0001] The invention relates to a gelatin drug carrier, a gelatin particle embolic agent and a preparation method and application thereof. Background technique [0002] Generally speaking, liver cancer (Hepatoma) is one of the most common cancers in the world, especially among men. The main cause of liver cancer is chronic hepatitis caused by hepatitis B virus and chronic hepatitis caused by hepatitis C virus. Chronic hepatitis caused by these viruses can lead to liver cirrhosis. If inflammation continues for a long time, liver cancer is very prone to occur. In addition, chronic liver diseases such as alcoholic liver disease or liver damage caused by toxins such as aflatoxin may also be the cause of liver cancer. [0003] Liver cancer can spread quickly, so early diagnosis is extremely important. Methods for treating liver cancer include: a method of removing cancer tissue by surgery; a method of using transarterial chemoembolization; Treatment (Radiofrequ...

Claims

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Application Information

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IPC IPC(8): A61K47/42A61K47/18A61K47/02A61K45/00A61K9/16A61K47/64A61P35/00A61L24/10
CPCA61K47/42A61K9/1658A61K45/00A61K47/02A61K47/18A61K47/183A61L24/0015A61L24/104A61L2300/416A61L2300/60A61L2300/802C08L89/06
Inventor 孙知祐
Owner HJ医疗器械有限公司