Radix pseudostellariae homogeneous polysaccharide for promoting insulin secretion of islet cells and use thereof

A technology of islet cells and insulin, applied in the field of homogeneous polysaccharides of Pseudostellariae Radix Pseudostellariae, can solve problems such as secondary failure, poisoning, and long course of disease, and achieve the effect of promoting insulin secretion in cells

Active Publication Date: 2017-03-22
福建省中医药科学院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chemical hypoglycemic drugs are very effective in controlling blood sugar, but they also have limitations and adverse reactions, such as hypoglycemia, lactic acidosis, secondary failure after long-term use, etc.
Diabetes has a long and complicated course of disease

Method used

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  • Radix pseudostellariae homogeneous polysaccharide for promoting insulin secretion of islet cells and use thereof
  • Radix pseudostellariae homogeneous polysaccharide for promoting insulin secretion of islet cells and use thereof
  • Radix pseudostellariae homogeneous polysaccharide for promoting insulin secretion of islet cells and use thereof

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Embodiment Construction

[0026] The present invention will be further described below in conjunction with specific examples, but the present invention is not limited to these examples.

[0027] 1. Embodiment

[0028] A preparation method of heterogeneous polysaccharide of Radix Pseudostellariae for promoting insulin secretion from pancreatic islet cells, the specific steps are as follows:

[0029] (1) Extraction of effective anti-T2DM polysaccharides from Radix Pseudostellariae:

[0030] (1) Take the dried Pseudostellariae Radix, crush it into a coarse powder, and pass through a 40-mesh sieve; use 8 times the amount of 90% ethanol to continuously reflux extract 3 times, each time for 2 hours, filter, and add appropriate amount of distilled water to continuously reflux extract 3 times , 2 hours each time, filter the combined filtrate, concentrate to an appropriate amount, and set aside;

[0031] (2) Use the Sevage method to remove protein from the water extract obtained in step (1), liquid medicine: ...

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Abstract

The invention discloses a radix pseudostellariae homogeneous polysaccharide for promoting insulin secretion of islet cells and use thereof. The radix pseudostellariae homogeneous polysaccharide provided by the invention is acidic polysaccharide, has a molecular weight of 4.8*10<4> Da and specific rotation [alpha] of D<25>+174.5DEG (c 0.485, H2O); the molecular formula consists of three elements: C, H, O, and C, H and O are in a ratio of 1:2.1:1.4. The radix pseudostellariae homogeneous polysaccharide is composed of monosaccharide galacturonic acid, rhamnose, galactose and arabinose, galactose uronic acid is a main monosaccharide component of polysaccharide, alpha-1, 4- connected galacturonic acid constitutes a main chain of polysaccharide. Part of galacturonic acid C6-OH undergoes methyl esterification, the hydroxyl on C2 and C3 are partly acetylized, a small amount of rhamnose exists on the main chain, and 1, 5- connected arabinose composes a branched chain. The radix pseudostellariae homogeneous polysaccharide can promote insulin secretion of Ins-1 cells, and provides the basis for application in development of anti-diabetic drugs, health care products and other fields in the future.

Description

technical field [0001] The invention relates to a homogeneous polysaccharide of heterophylla pseudostellariae for promoting the secretion of insulin by pancreatic islet cells and its application. Background technique [0002] Diabetes mellitus is a metabolic disease characterized by persistent hyperglycemia. With the improvement of people's living standards, changes in lifestyles, and increased work pressure, the incidence of diabetes has shown an obvious upward trend, becoming one of the diseases that seriously threaten human health. Diabetes is divided into two types. Type 1 diabetes mellitus (T1DM) is insulin-dependent, and type 2 diabetes mellitus (T2DM) is non-insulin-dependent. T2DM accounts for more than 90% of the total number of diabetic patients. Insulin insufficiency and insulin resistance (IR) are the main pathogenic mechanisms. According to the results of the "China Chronic Disease Monitoring and Diabetes Survey" released by the China Health Education Center, ...

Claims

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Application Information

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IPC IPC(8): C08B37/00A61K31/715A61P3/10
CPCA61K31/715A61K36/36C08B37/0003C08B37/006
Inventor 胡娟陈锦龙庞文生史文涛杨斌栗园
Owner 福建省中医药科学院
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