Radix pseudostellariae homogeneous polysaccharide for promoting insulin secretion of islet cells and use thereof

Abstract

The invention discloses a radix pseudostellariae homogeneous polysaccharide for promoting insulin secretion of islet cells and use thereof. The radix pseudostellariae homogeneous polysaccharide provided by the invention is acidic polysaccharide, has a molecular weight of 4.8*10<4> Da and specific rotation [alpha] of D<25>+174.5DEG (c 0.485, H2O); the molecular formula consists of three elements: C, H, O, and C, H and O are in a ratio of 1:2.1:1.4. The radix pseudostellariae homogeneous polysaccharide is composed of monosaccharide galacturonic acid, rhamnose, galactose and arabinose, galactose uronic acid is a main monosaccharide component of polysaccharide, alpha-1, 4- connected galacturonic acid constitutes a main chain of polysaccharide. Part of galacturonic acid C6-OH undergoes methyl esterification, the hydroxyl on C2 and C3 are partly acetylized, a small amount of rhamnose exists on the main chain, and 1, 5- connected arabinose composes a branched chain. The radix pseudostellariae homogeneous polysaccharide can promote insulin secretion of Ins-1 cells, and provides the basis for application in development of anti-diabetic drugs, health care products and other fields in the future.

Description

technical field [0001] The invention relates to a homogeneous polysaccharide of heterophylla pseudostellariae for promoting the secretion of insulin by pancreatic islet cells and its application. Background technique [0002] Diabetes mellitus is a metabolic disease characterized by persistent hyperglycemia. With the improvement of people's living standards, changes in lifestyles, and increased work pressure, the incidence of diabetes has shown an obvious upward trend, becoming one of the diseases that seriously threaten human health. Diabetes is divided into two types. Type 1 diabetes mellitus (T1DM) is insulin-dependent, and type 2 diabetes mellitus (T2DM) is non-insulin-dependent. T2DM accounts for more than 90% of the total number of diabetic patients. Insulin insufficiency and insulin resistance (IR) are the main pathogenic mechanisms. According to the results of the "China Chronic Disease Monitoring and Diabetes Survey" released by the China Health Education Center, ...

AI Technical Summary

Problems solved by technology

Chemical hypoglycemic drugs are very effective in controlling blood sugar, but they also have limitations and adverse reactions, such as hypoglycemia, lactic acidosis, secondary failure after long-term use, etc.

Diabetes has a long and complicated course of disease, basically cannot be cured, and eventually leads to multiple organ complications such as kidney disease; patients often need long-term or even life-long medication, and the side effects of the damage to the human body are difficult to overcome due to accumulation

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