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Alginate/hydroxyapatite super-long nanowire composite hydrogel

A technology of hydroxyapatite and composite hydrogel, which is applied in the direction of prosthesis, inorganic non-active ingredients, aerosol delivery, etc. It can solve the problems of difficult to obtain mechanical properties, complex shape, uncontrollable gelation rate, etc. problems, to achieve good application prospects, uniform structure, good biocompatibility and mechanical properties

Active Publication Date: 2017-04-19
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Researchers have done a lot of research on the preparation of alginate hydrogels. The commonly used gelation method is ion cross-linking. During cross-linking, the alginate solution is usually added dropwise to the calcium salt solution, but the obtained The gelation rate of the gel is uncontrollable, and it is difficult to obtain a three-dimensional structure with good mechanical properties, uniform structure, and complex shape

Method used

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  • Alginate/hydroxyapatite super-long nanowire composite hydrogel
  • Alginate/hydroxyapatite super-long nanowire composite hydrogel
  • Alginate/hydroxyapatite super-long nanowire composite hydrogel

Examples

Experimental program
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Effect test

Embodiment 1

[0042] Embodiment 1 Preparation of hydroxyapatite ultra-long nanowires

[0043] At room temperature, respectively, 0.1760g CaCl 2 , 0.3480g NaH 2 PO 4 , Dissolve 0.700g NaOH in 10mL deionized water. Mix 9mL deionized water, 4mL methanol, and 7mL oleic acid for 30min under magnetic stirring, then add 10mL CaCl dropwise 2 solution, 10mL NaOH solution, 10mL NaH 2 PO 4 The solution was stirred for 30 min. Then transfer the mixed solution to a 100mL reaction kettle, seal it, react at 180°C for 24h, and cool it down to room temperature naturally. The aqueous suspension of long nanowires had a pH close to 7.4 and was then stored at 4°C. Finally, hydroxyapatite ultralong nanowires are obtained, such as Figure 1a with 1b shown.

Embodiment 2

[0044] Embodiment 2 (pure calcium alginate hydrogel)

[0045] At room temperature, 2.0000g CaCl 2 Dissolve in 100 ml of deionized water, dissolve 0.2000 g of sodium alginate in 10 ml of water, and stir at room temperature for 90 min to fully dissolve the sodium alginate. Afterwards, the sodium alginate solution was transferred to a mold of a certain shape, and a water-soluble calcium salt solution was sprayed on it to form a gel. After the gel was formed, the mold and the composite hydrogel in it were immersed in CaCl at 37°C. 2 In the aqueous solution for 12h, the calcium ions diffuse evenly in the composite hydrogel. The internal pore diameter of the pure calcium alginate hydrogel is 200-500 μm, and the internal pore diameter of the pure calcium alginate hydrogel is connected. Its maximum tensile strength is 0.086MPa, tensile Young's modulus is 0.162MPa, maximum compressive strength is 0.061MPa, and compressive modulus E 50％ is 0.075MPa.

Embodiment 3

[0047] At room temperature, 2.0000g CaCl 2 Dissolve in 100ml deionized water, dissolve 0.2000g sodium alginate in 10ml deionized water containing 0.0400g hydroxyapatite ultra-long nanowires, stir at room temperature for 90min to fully dissolve sodium alginate, and mix with hydroxyapatite Stone ultra-long nanowires are mixed evenly. The sodium alginate solution is then transferred to a shaped mold on which CaCl is sprayed 2 The aqueous solution makes it gel, and after the gel is formed, the mold and the composite hydrogel in it are immersed in CaCl at 37°C 2 In the aqueous solution for 12h, the calcium ions diffuse evenly in the composite hydrogel. The maximum tensile strength of the alginate / hydroxyapatite ultra-long nanowire composite hydrogel is 0.137MPa, the tensile Young's modulus is 0.253MPa, the maximum compressive strength is 0.090MPa, and the compressive modulus E 50％ is 0.089MPa.

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Abstract

The invention relates to alginate / hydroxyapatite super-long nanowire composite hydrogel. The alginate / hydroxyapatite super-long nanowire composite hydrogel comprises water-soluble alginate and hydroxyapatite super-long nanowires. According to the alginate / hydroxyapatite super-long nanowire composite hydrogel, the water-soluble alginate is combined with the hydroxyapatite super-long nanowires for the first time, and the alginate / hydroxyapatite super-long nanowire composite hydrogel with the alginate hydrogel as the base and the hydroxyapatite super-long nanowires as a reinforcing material is obtained finally. The prepared alginate / hydroxyapatite super-long nanowire composite hydrogel has the good mechanical performance and also has the good biocompatibility characteristic.

Description

technical field [0001] The invention relates to an alginate / hydroxyapatite superlong nanowire composite hydrogel, which comprises two components of alginate and hydroxyapatite superlong nanowire, and has a connected pore structure and good mechanical properties, belonging to the field of biomaterial preparation. Background technique [0002] Biomedical composite materials are biomedical materials composed of two or more different materials, which are mainly used for the repair and replacement of human tissue and the construction of artificial organs. Long-term clinical application found that a single material generally cannot well meet the requirements of clinical application. Biomedical composite materials made of materials with different properties not only have the properties of component materials, but also can obtain new properties that single-component materials do not have. With a broad approach, biomedical composite materials have become an important research field...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08J3/24C08J9/00C08L5/04C08K7/08A61K9/06A61K47/04A61K47/36A61L27/20A61L27/12A61L27/56A61L27/52A61L27/50
CPCA61K9/06A61K47/02A61K47/36A61L27/12A61L27/20A61L27/50A61L27/52A61L27/56A61L2430/02C08J3/075C08J3/24C08J9/0076C08J2305/04C08K7/08C08K2201/011C08L5/04
Inventor 朱英杰姜莹莹陈峰
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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