Applications of polydatin, and neuron mitochondrion injury treating medicine and preparation method thereof

A polydipside and neuron technology, applied in the field of medicine, can solve the problems that the drug target of polydipside cannot be fully explained, the mechanism research is less, and the mitochondrial damage of polydipside neuron has not been reported.

Inactive Publication Date: 2017-04-26
杨翃
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the above-mentioned prior art is mostly limited to superficial observation and simple mechanism research on the brain protection effect of polydatin, and there are few systematic and in-depth researches on the mechanism, and there is no report on the damage of polydatin neuron mitochondria.
[0005] Most of the existing studies on the brain protection of polydatin are l

Method used

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  • Applications of polydatin, and neuron mitochondrion injury treating medicine and preparation method thereof
  • Applications of polydatin, and neuron mitochondrion injury treating medicine and preparation method thereof
  • Applications of polydatin, and neuron mitochondrion injury treating medicine and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] Preparation of a drug method for treating neuron mitochondrial damage, comprising the following steps:

[0062] Step 1: react TMC, triphenylphosphine and thionyl chloride in cyclohexanone solution, the reaction temperature is 80°C, the reaction time is 8h, after the reaction is completed, filter, wash the precipitate with distilled water, centrifuge, and vacuum dry to obtain Product 1;

[0063] Step 2: Dissolve the product 1 obtained in Step 1 in an ethyl acetate solution with a volume fraction of 1%, add a genipin solution with a mass fraction of 0.5% dropwise at room temperature, stir while dripping, and react for 6 hours to obtain a mixture solution;

[0064] Step 3: Sterilize the mixed solution obtained in Step 2 through a 0.22 μm filter membrane, and put it in a sterile operating table for use;

[0065] Step 4: Take 1 mL of the mixed solution obtained in Step 3 and add it to centrifuge tube 1, and add polydatin to centrifuge tube 2, add sterile water to centrifug...

Embodiment 2

[0068] Preparation of a drug method for treating neuron mitochondrial damage, comprising the following steps:

[0069] Step 1: react TMC, triphenylphosphine, and thionyl chloride in a cyclohexanone solution with a ratio of 1:1.5:1.5, the reaction temperature is 90°C, and the reaction time is 90h. After the reaction is completed, filter, The precipitate was washed with distilled water, centrifuged, and vacuum-dried to obtain product 1;

[0070] Step 2: Dissolving the product 1 obtained in step 1 in a 1% ethyl acetate solution by volume fraction, adding dropwise a genipin solution with a mass fraction of 0.5% at room temperature, the ratio of the amount of genipin to the product 1 1:1, stirring while dripping, reacted for 10h, and prepared a mixed solution;

[0071] Step 3: Sterilize the mixed solution obtained in Step 2 through a 0.22 μm filter membrane, and put it in a sterile operating table for use;

[0072] Step 4: Take 1 mL of the mixed solution obtained in Step 3 and ad...

Embodiment 3

[0075] Preparation of a drug method for treating neuron mitochondrial damage, comprising the following steps:

[0076] Step 1: react TMC, triphenylphosphine and thionyl chloride in a solution of cyclohexanone with a ratio of 1:1.5:1.5, the reaction temperature is 85°C, and the reaction time is 20h. After the reaction is completed, filter, The precipitate was washed with distilled water, centrifuged, and vacuum-dried to obtain product 1;

[0077] Step 2: Dissolving the product 1 obtained in step 1 in a 1% ethyl acetate solution by volume fraction, adding dropwise a genipin solution with a mass fraction of 0.5% at room temperature, the ratio of the amount of genipin to the product 1 1:1, stirring while dripping, reacted for 8h, and obtained a mixed solution;

[0078] Step 3: Sterilize the mixed solution obtained in Step 2 through a 0.22 μm filter membrane, and put it in a sterile operating table for use;

[0079] Step 4: Take 1 mL of the mixed solution obtained in Step 3 and a...

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Abstract

The present invention belongs to the field of medicine, and particularly relates to applications of polydatin in preparation of neuron mitochondrion injury treating medicines, a medicine containing the polydatin, and a medicine preparation method. The present invention provides applications of polydatin in preparation of neuron mitochondrion injury treating medicines. According to the present invention, the polydatin provides significant effects in protection of neuron mitochondrion injury, and can be used for treating or preventing diseases related to neuron mitochondrion injury; the neuron mitochondrion protection effect of the polydatin is researched on the basis of the determination of the key role of the neuron mitochondrion injury in secondary brain injury, such that the target is clear, and the targeting property is strong; and compared to a variety of mitochondrion protection agents, the polydatin of the present invention has the following characteristics that the neuron mitochondrion protection effect of the polydatin is subjected to the multi-layer research, the design is cautious and reasonable, and the conclusion is reliable.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the application of polydatin for preparing medicine for treating neuron mitochondrial damage, the medicine containing polydatin for treating neuron mitochondrial damage and the preparation method of the medicine. Background technique [0002] The pharmacological effects of polydatin include: anti-inflammation, anti-shock, anti-oxidative stress, improvement of microcirculation, and improvement of ischemia-reperfusion injury; studies have found that polydatin has a significant effect on cerebral hemorrhage injury and cerebral ischemia-reperfusion inflammation in rats. The injury has a protective effect; the mechanism involved may include: scavenging oxygen free radicals, inhibiting the release of inflammatory mediators, and scavenging excitatory amino acids. [0003] In terms of existing patents, the publication number is: CN101411716B, and the patent name is the use of polydatin for the pr...

Claims

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Application Information

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IPC IPC(8): A61K9/51A61K31/7034A61K47/36A61P25/00
CPCA61K9/5161A61K31/7034
Inventor 杨翃
Owner 杨翃
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