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Mouthwash powder containing sodium azulene sulfonate and preparation method thereof

A technology of sodium azulene sulfonate and filler, applied in the field of mouthwash powder containing sodium azulene sulfonate and its preparation field, can solve the problems of inconvenience and instability of the sodium azulene sulfonate medicament to carry, achieve good antioxidant effect, Convenient storage and transportation, good stability

Active Publication Date: 2019-02-26
石家庄凯达生物工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] One of the purposes of the present invention is to provide a mouthwash powder containing sodium azulene sulfonate to solve the problem of inconvenient and unstable carrying of the existing sodium azulene sulfonate medicament

Method used

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  • Mouthwash powder containing sodium azulene sulfonate and preparation method thereof
  • Mouthwash powder containing sodium azulene sulfonate and preparation method thereof
  • Mouthwash powder containing sodium azulene sulfonate and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A mouthwash powder containing sodium azulene sulfonate, prepared from the following raw materials in terms of mass percentage: 0.4% sodium azulene sulfonate, 0.25% tea polyphenols, 2% sodium bicarbonate, and 94.65% mannitol , Povidone K30 1.5%, Menthol 1%, Flavor 0.2%. Mix the sodium azulene sulfonate and tea polyphenol weighed according to the above amount evenly, mix the obtained mixture with other auxiliary materials by equal addition method, then pass through a 100-mesh sieve twice, mix for 10 minutes, and finally prepare the powder According to 1g / package, it is packed into aluminum-plastic bags.

Embodiment 2～7、 comparative example 1

[0029] Change the amount of tea polyphenols, and simultaneously change the amount of mannitol (see Tables 1-4 for details), and the other raw materials and preparation methods are the same as in Example 1.

[0030] Stability tests were carried out on all the above-mentioned samples, and the test method was as follows.

[0031] The stability test of the present invention is divided into an accelerated test and a long-term test. The accelerated test is to place the sample in a constant temperature and humidity box, store it for 6 months at a temperature of 40°C ± 2°C, and a humidity of 75% ± 5%, and then Take samples at the end of the 0th day and the 1st, 2nd, 3rd, and 6th months, observe the color change and detect the content of sodium azulene sulfonate in the sample, and obtain the proportion of sodium azulene sulfonate in the sample at different times in the initial formula of sodium azulene sulfonate The percentage of dosage, the color change result are shown in Table 1, an...

Embodiment 8

[0046] A mouthwash powder containing azulene sulfonate sodium, prepared from the following raw materials in terms of mass percentage: 0.1% sodium azulene sulfonate, 0.25% tea polyphenols, 2% sodium bicarbonate, and 94.95% mannitol , Povidone K30 1.5%, Menthol 1%, Flavor 0.2%. Mix the sodium azulene sulfonate and tea polyphenol weighed according to the above amount evenly, mix the obtained mixture with other auxiliary materials by equal addition method, then pass through a 100-mesh sieve twice, mix for 10 minutes, and finally prepare the powder According to 1g / package, it is packed into aluminum-plastic bags.

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Abstract

The invention provides mouthwash powder containing sodium gualenate and a preparation method thereof. The mouthwash powder contains tea polyphenol and is prepared from 0.1% to 1% by weight of sodium gualenate, 0.1% to 1% by weight of tea polyphenol and the balance of auxiliary materials. The auxiliary materials comprise a filler, a disintegrant, a pH adjuster, a binder and a flavoring agent. The preparation method comprises uniformly mixing the sodium gualenate and tea polyphenol, uniformly mixing the obtained mixture and other auxiliary materials through an equivalent decreasing method, screening the mixture and carrying out split charging by plastic bags. The mouthwash powder has the advantages of good stability, good curative effect and carry and use convenience.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a mouthwash powder containing sodium azulene sulfonate and a preparation method thereof. Background technique [0002] Sodium azulene sulfonate is the active ingredient of chamomile flower. Its pharmacological mechanism is to directly inhibit the migration of white blood cells to the outside of the body and inhibit the release of histamine and PGE from mast cells without going through the pituitary-adrenal system. 2 Synthesis, inhibition of inflammation caused by various inflammatory substances, direct and long-lasting effect, and can promote the synthesis of granulation and the repair of epithelial cells, so it is mainly used to treat pharyngitis, tonsillitis, stomatitis, acute gingivitis, glossitis and oral ulcers. At present, sodium azulene sulfonate is only used to treat oral diseases in aqueous solution, which has disadvantages such as inconve...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/185A61K9/14A61K47/46A61K47/22A61P1/02A61P11/04A61P11/00A61P31/12A61K8/46A61K8/9789A61K8/49A61K8/02A61Q11/00
CPCA61K8/022A61K8/466A61K8/498A61K8/97A61K9/145A61K9/148A61K31/185A61K2800/522A61Q11/00
Inventor 秦旭荣高玉芹安庆军张丽芳房桂珍
Owner 石家庄凯达生物工程有限公司