Positron-nuclide-labeled dansyl amido diphenylethylene compound and synthesis method and application thereof

A technology based on dansylamide and methoxystilbene, which is applied in measuring devices, material analysis through optical means, instruments, etc., can solve the dual mode of PET without targeting cell apoptosis and targeting β-amyloid protein Imaging agents and other issues, to achieve the effect of easy automatic labeling, high radiochemical yield, and great application prospects
CN106581701AActive Publication Date: 2017-04-26GUANGDONG HUIXUAN PHARMA TECH
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
GUANGDONG HUIXUAN PHARMA TECH
Publication Date
2017-04-26

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Abstract

The invention relates to an optics and positron emission tomography (PET) dual-mode developer (formula 1) targeted to apoptotic cells and beta-amyloid protein, namely, a positron-nuclide-labeled 4-dansyl amido-4'-diphenylethylene compound. A synthesis method of the compound includes the steps that dansyl targeted to apoptotic cells and 1,2-diphenylvinyl-amino targeted to beta-amyloid protein are bound together, and then labeling is conducted. The compound is simple in radiosynthesis method, high in radiochemical yield and convenient to synthesize automatically, has broad application prospects and can be applied to anti-tumor therapy monitoring and differential diagnosis and scientific research on neurological and psychotic disorders like Alzheimer disease (AD). The formula 1 is defined in the description.
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Description

[0001] 【Technical Field】

[0002] The present invention relates to an optical and PET dual-mode imaging agent for targeting apoptotic cells and targeting β amyloid: positron nuclide labeling 4-dansylamide-4'-stilbene-based compounds, and a synthesis method thereof And its application in the preparation of anti-tumor therapy monitoring and differential diagnosis and scientific research drugs for senile dementia (AD) and other neuropsychiatric diseases.

[0003] 【Background technique】

[0004] Apoptosis is the orderly death of cells autonomously controlled by genes, and is a special form of death of eukaryotic cells. Apoptosis has important biological significance and can be seen in many physiological processes such as embryonic development, tissue differentiation, and immune regulation. Its abnormal regulation is associated with the occurrence of various malignant tumors, myocardial infarction, viral infectious diseases, and neurodegenerative diseases. Development is closely related ...

Claims

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