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Application of zinc in preparation of bone or joint restoration regeneration material

A technology for repairing regeneration, joints, applied in the field of chemistry to achieve easy-to-obtain results

Inactive Publication Date: 2017-04-26
SECOND AFFILIATED HOSPITAL SECOND MILITARY MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Ca 2 ZnSi 2 o 7 The zinc-calcium molar ratio of the ceramic coating is 0.5. Although experiments have confirmed that it has a significant role in promoting a series of biological activities of MC3T3-E1 cells, such as adhesion promotion, proliferation, osteogenic differentiation, and mineralization, the zinc It is still questionable whether the calcium molar ratio is optimal, and whether this material has the same excellent effect for more promising and practical BMSCs

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  • Application of zinc in preparation of bone or joint restoration regeneration material
  • Application of zinc in preparation of bone or joint restoration regeneration material
  • Application of zinc in preparation of bone or joint restoration regeneration material

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Embodiment Construction

[0028] The present invention proposes an application of zinc in the preparation of bone or joint repair regeneration materials. The zinc-modified calcium silicate coating is prepared from tetraethyl orthosilicate, zinc nitrate and calcium nitrate, and the zinc-modified calcium silicate The paint is coated on the surface of the bone or joint repair regeneration material to form a zinc-modified calcium silicate coating, and is co-cultured with the BMSCs in the bone or joint repair material.

[0029] The molar ratio of zinc to calcium in the zinc-modified calcium silicate is 0.3.

[0030] The BMSCs are BMSCs in the logarithmic growth phase of the fourth generation.

[0031] The molar ratio of zinc to calcium in the zinc-modified calcium silicate is 1:0.1:1, 1:0.3:1 or 1:0.5:1.

[0032] 1. Materials and methods

[0033] (1) Materials

[0034] 1. Experimental materials and instruments

[0035] Titanium alloy sheet, CaSiO 3 Ceramic-coated titanium sheet, zinc-modified calcium...

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Abstract

The invention relates to the technical field of chemistry, and concretely relates to an application of zinc in the preparation of a bone or joint restoration regeneration material. A zinc modified calcium silicate coating is prepared from ethyl orthosilicate, zinc nitrate and calcium nitrate, the surface of the bone or joint restoration regeneration material is coated with the zinc modified calcium silicate coating to form a zinc modified calcium silicate coating layer, and the coating layer and BMSCs are cocultured. The BMSCs are cultured on the surface of every group material in experiments in the invention, and biological influences of a Ca2ZnSi2O7 ceramic coating layer on the BMSCs are researched through adherence, proliferation and differentiation experiments, so influences of the surface morphology and the chemical components of the zinc modified calcium silicate coating layer and bioactive ions released by the coating layer on the BMSCs are confirmed, and the zinc modified calcium silicate coating layer with a molar ratio of zinc / calcium of 0.3 has a best BMSCs bioactivity promotion effect.

Description

technical field [0001] The invention relates to the field of chemical technology, in particular to the application of zinc in preparing regeneration materials for bone or joint repair. Background technique [0002] It is well known that the interaction between cells and substrates is a key factor affecting cell activity, including cell adhesion, proliferation and differentiation. Related experiments have demonstrated that the surface morphology and chemical composition of biomaterials can have significant biological effects on cells. For example, Zreiqat et al. have shown that surface chemical modification of titanium alloy (Ti-6Al-4V) with divalent trace elements such as magnesium (Mg) and zinc (Zn) can modulate the activity of bone cells. [0003] In recent years, hydroxyapatite (HA) has been widely used clinically to form a coating on the surface of implants by plasma spraying. Its ability to induce the growth of surrounding bone tissue is undoubted, but the bonding stre...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/06A61L27/30A61L27/38A61L31/02A61L31/08
CPCA61L27/06A61L27/306A61L27/3834A61L27/3847A61L31/022A61L31/088A61L2420/02A61L2430/02A61L2430/24
Inventor 余将明叶哓健徐立璋李恺谢宁
Owner SECOND AFFILIATED HOSPITAL SECOND MILITARY MEDICAL UNIV
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