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ALD technology-based energy saving method for producing oxidation layer on medical device

A technology of medical devices and oxide layers, applied in coating, surgery, medical science, etc., can solve problems such as cracking, polymer drug-loaded layer shedding, human body skills, etc., to achieve change in adhesion and excellent large-area uniformity , to avoid the effect of shedding and cracking

Inactive Publication Date: 2017-04-26
天津丰茂科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide an energy-saving method for preparing an oxide layer on a medical device based on ALD technology, so as to solve the problem of the existing implantable medical device in the in vivo environment and the stent in the prior art proposed in the above background technology. During the expansion process, the polymer drug-loaded layer is prone to shedding and cracking, causing new medical problems, and with the use of non-degradable polymer materials, it will also have a certain impact on the skills of the human body

Method used

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  • ALD technology-based energy saving method for producing oxidation layer on medical device

Examples

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Embodiment 1

[0020] A method for preparing an oxide layer on a spinal internal fixator based on ALD technology,

[0021] Take out the internal fixator of the spine, remove the dust and oil stains attached to the surface, place it in the medical equipment cleaning and disinfection device, turn on the rotating motor and the cleaning nozzle to perform the rotation cleaning operation of the internal fixator of the spine, and then place it in the drying room after cleaning Carry out high-temperature drying and sterilization operations in the device, and take out the dried spinal internal fixer for use;

[0022] Select suitable alumina and silica for future use;

[0023] Use the dried and sterilized fixture to clamp the spinal internal fixer and put it into the operation cavity of ALD. At the same time, adjust the working temperature of the ALD deposition device to 100 ° C, adjust the flow rate of the carrier gas to 500 sccm, and evacuate the ALD studio, and Pass inert gas for cleaning operatio...

Embodiment 2

[0028] A method for preparing an oxide layer on an implantable alloy medical device based on ALD technology,

[0029] Similar to Example 1, the difference is that the working temperature, carrier gas flow and carrier gas pressure in the ALD deposition device can be adjusted, wherein the working temperature is set at 25-300 ° C, the carrier gas flow is set at 500-1000 sccm, and the inert The opening rate of the gas throttle valve can be increased to 50%, the probe voltage displayed by the oxygen detector is 920mV, and the temperature of the curing oven can be set at 200°C during the curing operation, and the curing time can be increased to 6h. During the treatment process, the mass ratio of titanate, hydrochloric acid, silver nitrate and zinc nitrate can be adjusted to 5%, 0.5%, 0.5% and 2.5%;

[0030]When preparing an oxide layer for implantable alloy medical devices, different from the oxidation operation for spinal internal fixers, 100-200 cyclic ALD deposition operations ca...

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Abstract

An ALD technology-based energy saving method for producing an oxidation layer on a medical device concretely comprises the following steps: 1, cleaning and drying; 2, oxide selection; 3, gas introduction; 4, thickness selection; 5, solidification; and 5, antibacterial treatment. A gas phase is alternately introduced to a reactor through an atom layer deposition technology and undergoes a chemical reaction to form a film. An oxidation layer with the thickness of 100-200 nm is produced on the surface of an implantable alloy medical device, has very good stability and compactness, changes the adhesiveness, the biocompatibility and the blood compatibility, and avoids new medical problems caused by influences of shedding and cracking phenomena of a polymeric drug delivery layer of the implantable alloy medical device and non-degradable polymeric materials on functions of human bodies in in-vivo environment and in the expansion process of a scaffold.

Description

technical field [0001] The invention relates to the technical field of energy saving and environmental protection, in particular to an energy-saving method for preparing an oxide layer on a medical device based on ALD technology. Background technique [0002] Medical devices refer to instruments, equipment, utensils, in vitro diagnostic reagents and calibrators, materials, and other similar or related items that are used directly or indirectly on the human body, including the required computer software. Implantable medical devices are used in medical operations It has been applied more and more. Any instrument that enters the human body or the natural orifice in whole or in part by means of surgery; stays in the body for a long time after the surgical procedure, or part of these instruments remain in the body for at least 30 days, these instruments are considered to be Implantable devices. With the continuous development of my country's implantable medical device industry, dom...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/08A61L31/16C23C16/40C23C16/455
CPCA61L31/088A61L31/08A61L31/16A61L2300/102A61L2300/404A61L2300/606A61L2420/02A61L2420/04A61L2420/08C23C16/40C23C16/45555
Inventor 徐福春
Owner 天津丰茂科技有限公司
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