Synthesis method and application of hapten of tetrabromobisphenol A derivative TBBPA-MBPE

A technology of tetrabromobisphenol and synthesis method, which is applied in the field of surgery, can solve the problems of specificity and polarity of the analyte, and achieve the effect of strong specificity and high antibody titer

Inactive Publication Date: 2017-04-26
JIANGSU UNIV
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Problems solved by technology

However, most of the analyte molecules do not contain functional groups, or the functional groups have a great influence on the specif

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  • Synthesis method and application of hapten of tetrabromobisphenol A derivative TBBPA-MBPE
  • Synthesis method and application of hapten of tetrabromobisphenol A derivative TBBPA-MBPE

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[0027] In order to make the objectives, technical solutions, and advantages of the present invention clearer, the following further describes the present invention in detail with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described here are only used to explain the present invention, but not to limit the present invention.

[0028] (1) Using TBBPA as a raw material, substituted with methyl bromoacetate and allyl bromide to generate methyl-2-(4-(2-(4-(allyloxy)-3,5-dibromophenyl)propane -2-yl)-2,6-dibromophenoxy)ethyl acetate (a);

[0029] Add K to 10ml of DMF with TBBPA (3.24g) dissolved 2 CO 3 (2.4g), methyl bromoacetate (918mg) was added dropwise at 100°C, and stirring was continued for 12h. Allyl bromide (0.242g, 0.002mol) was added dropwise to the reaction solution for 4h. It was washed with water, and the organic phase was extracted 3 times with 20 mL of ethyl acetate, concentrated and purified to obtain comp...

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Abstract

The invention provides a synthesis method and application of hapten of a tetrabromobisphenol A derivative TBBPA-MBPE. The synthesis method comprises the following steps that 1, TBBPA is taken as a raw material to be subjected to a substitution reaction with methyl bromoacetate and allyl bromide, and methyl-2-(4-(2-(4-(allyloxy)-3,5-dibromo phenyl)propyl-2-yl)-2,6-dibromo phenoxy)ethyl acetate is generated; 2, methyl-2-(4-(2-(4-(allyloxy)-3,5-dibromo phenyl)propyl-2-yl)-2,6-dibromo phenoxy)ethyl acetate is subjected to a saponification reaction with sodium hydroxide, acidification is conducted with hydrochloric acid, and hapten 2-(4-(2-(4-(allyloxy)-3,5-dibromo phenyl)propyl-2-yl)-2,6-dibromo phenoxy)acetic acid is obtained; 3, the hapten is subjected to an addition reaction with liquid bromine and then subjected to a quenching reaction with Na2S2CO3, and then the hapten 2-(2,6-dibromo-4-(2-(3,5-dibromo-4-(2,3-dibromo propoxy)phenyl)propyl-2-yl)phenoxy)acetic acid is obtained. The hapten of the tetrabromobisphenol A derivative TBBPA-MBPE is successfully designed and synthesized through repeated tests, and the method is simple, safe and feasible.

Description

Technical field [0001] The present invention belongs to the technical field of tetrabromobisphenol A derivative TBBPA-MBPE hapten, and in particular relates to a tetrabromobisphenol A derivative TBBPA-MBPE hapten synthesis method, and refers to a tetrabromobisphenol A derivative TBBPA-MBPE One of the side chains of the benzene ring is modified to provide a synthetic method for coupling with a carboxyl group, specifically a method for synthesizing a tetrabromobisphenol A derivative TBBPA-MBPE hapten and its use. Background technique [0002] Immunoassay is an analysis method based on the specific reaction of antigen and antibody, and it has been widely used in the analysis and detection of small molecule pollutants in food and the environment. This method has the advantages of high sensitivity, convenience, high throughput, and low cost. The premise of establishing this method is the development of corresponding antibodies. Because of their small molecular weight and lack of imm...

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Application Information

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IPC IPC(8): C07C67/31C07C69/712C07C27/02C07C59/70C07C51/363C07K14/765
CPCC07C51/09C07C51/363C07C59/70C07C67/31C07K14/765C07C69/712
Inventor 张祯梁亚如曾昆吴向阳张萌黄梦璐
Owner JIANGSU UNIV
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