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Application of Cottonone in Preparation of Anti-aging Medicine and Health Food

A technology of cottonone and anti-aging, which is applied in the field of active ingredients of traditional Chinese medicine, and can solve problems such as no reports on anti-aging effects

Active Publication Date: 2019-04-05
SHANXI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies have shown that cottonone has anti-inflammatory, anti-allergic, anti-cancer and other activities, but whether it has anti-aging effects has not been reported

Method used

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  • Application of Cottonone in Preparation of Anti-aging Medicine and Health Food
  • Application of Cottonone in Preparation of Anti-aging Medicine and Health Food
  • Application of Cottonone in Preparation of Anti-aging Medicine and Health Food

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] The preparation of embodiment 1 Paradone

[0014] Take 1 kg of dried coltsfoot flower and crush it, ultrasonically extract it with petroleum ether for 3 times, each time for 100 min, filter the extract, and concentrate under reduced pressure to obtain 1.23 g of crude extract.

[0015] Take n-hexane, ethyl acetate, methanol, and water (10:5:11:3) in a separatory funnel, let it stand for stratification, the upper phase is the stationary phase, and the lower phase is the mobile phase, and the stationary phase is filled with a pump. Fill the separation column, take the crude extract and dissolve it in the stationary phase to load the sample. When the speed of the main engine reaches 800rpm, pump the mobile phase at a flow rate of 2ml / min. When the mobile phase flows out, collect the target components according to the detector spectrum, concentrate and dry to get coltsfoot Crude ketones. Using petroleum ether-ethyl acetate (35:1) as the eluent, use a silica gel column to se...

Embodiment 2

[0016] Embodiment 2 Paradone anti-aging pharmacodynamics experiment

[0017] 1 material

[0018] 1.1 Model organisms

[0019] Caenorhabditis legans (C.elegans) N2 was kindly provided by Enbo Ma's group at the Institute of Applied Biology, Shanxi University.

[0020] 1.2 Drugs and reagents

[0021] Escherichia coli OP50 (E.coil OP50) was kindly provided by Enbo Ma’s group at the Institute of Applied Biology, Shanxi University, 5-fluoro-2′-deoxyuridine (FUdR) was purchased from sigma (USA), agar powder was purchased from Solarbio (Beijing), peptone was purchased from Beijing Aoboxing Biotechnology Co., Ltd., and other inorganic reagents were purchased from Tianjin Fengchuan Chemical Reagent Co., Ltd. Standard nematode medium NGM medium: each liter medium contains 3g sodium chloride, 21g agar powder, 2.5g peptone, 1mL cholesterol ethanol solution (concentration: 5mg / mL), 1mL CaCl 2 Solution (1mol / L), 1mLMgSO 4 solution (1mol / L) and 25mLKH 2 PO 4 -K 2 HPO 4 Buffer solutio...

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Abstract

The invention provides application of tussilagone in preparing antiaging drugs and health-care food, which belongs to novel application of active ingredients of traditional Chinese medicine tussilagone. An experiment result indicates that the tussilagone with the concentration of 20 mu M can prolong the average life of nematode by 23.6 percent, the medium life by 25 percent and the maximum life by 25.8 percent. The tussilagone can be used to prepare the antiaging drugs or health-care food as an active ingredient.

Description

technical field [0001] The invention relates to active ingredients of traditional Chinese medicines, in particular to a new application of cottonone, in particular to the application of cottonone in the preparation of anti-aging medicine and health food. Background technique [0002] With the improvement of medical conditions, the average life expectancy of human beings is continuously extending, and at the same time, the problem of population aging is gradually becoming serious. By the end of 2006, there were 104.19 million people over the age of 65, accounting for 7.9% of the total population. It is estimated that when the population reaches its peak in 2050, the total number of elderly people will exceed 400 million, and the aging level will advance to more than 30%, which is close to the sum of the world's elderly population in 1980. With the increasingly severe situation of population aging, research on aging mechanism and anti-aging drugs has become a hot spot and key...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/22A61P39/06A23L33/10
CPCA23V2002/00A61K31/22A61K36/28A23V2200/302
Inventor 李震宇李静张建琴薛晓莉秦雪梅
Owner SHANXI UNIV