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Amino acid modified metallofullerene water-soluble nanoparticles as well as preparation method and application thereof

A metallofullerene and nanoparticle technology, applied in the field of nanomaterials, can solve the problems of organic solvents not being simple, economical, green and environmentally friendly, and achieve the effect of simple and economical preparation method and small particle size distribution

Inactive Publication Date: 2017-05-10
BEIJING FUNAKANG BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the method of modifying amino acids on the surface of carbon cages is mainly to use the toluene solution of fullerene to react with the alkaline aqueous solution of amino acids. The use of organic solvents in the reaction process does not meet the purpose of simplicity, economy, and environmental protection.

Method used

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  • Amino acid modified metallofullerene water-soluble nanoparticles as well as preparation method and application thereof
  • Amino acid modified metallofullerene water-soluble nanoparticles as well as preparation method and application thereof
  • Amino acid modified metallofullerene water-soluble nanoparticles as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Put about 10mg Gd@C 82 The solid was added to a 10ml one-mouth bottle, and 6ml of β-alanine alkali solution with a mass fraction of NaOH of 14% was added (the molar ratio of amino acid to sodium hydroxide was specifically 1:2; β-alanine and Gd@C 82 The molar ratio of the mixture is 1000:1), vigorously stirred at 50°C for 1.5h, the black solid gradually dissolved to form a brown-black solution. A small amount of unreacted solid powder is removed by filtration, and the filtrate is dialyzed with a Mw=3500 dialysis bag to remove small molecular impurities, and the brown-black solution obtained after filtering with a 220nm microporous membrane is the amino acid-modified metallofulerene water-soluble nanometer Granular Gd@C 82 (OH) 13 (NHCH 2 CH 2 COOH) 6 .

[0044] Table 1 Elemental analysis results of metallofullerene water-soluble nanoparticles modified by β-alanine

[0045]

[0046] The elemental ratios of carbon, nitrogen, and hydrogen obtained by elemental ana...

Embodiment 2

[0053] With purified 10mg Gd@C 82 Mix the solid with 6mL of L-lysine alkali solution with a mass fraction of 14% NaOH (the molar ratio of L-lysine to NaOH is 1:2), and stir vigorously at 50°C for 2 hours, the black solid gradually dissolves to form a brown-black solution , all the other conditions are the same as Example 1 of the present invention.

Embodiment 3

[0055] With purified 10mg Gd@C 82 Mix the solid with 6mL of L-serine alkali solution with a mass fraction of 14% NaOH (the molar ratio of L-serine to NaOH is 1:2), stir vigorously at 50°C for 4h, the black solid gradually dissolves to form a brown-red solution, and the rest of the conditions are the same Embodiment 1 of the present invention.

[0056] Such as Figure 7 Shown, for Gd@C 82 Particle size distribution curves of different amino acid nanoparticles in water at pH=7. Depend on Figure 7 As can be seen from Table 2, the average particle size of the lysine reaction product is the smallest and the distribution is the widest; the average particle size of the serine reaction product is the largest and the distribution is the narrowest.

[0057] Table 2 Gd@C 82 The average particle size and zeta potential of different amino acid nanoparticles in water at pH=7

[0058]

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Abstract

The invention discloses amino acid modified metallofullerene water-soluble nanoparticles as well as a preparation method and an application thereof. The general structural formula of the amino acid modified metal fullerene water-soluble nanoparticles is metallofullerene@C2n(OH)x(Amino Acid)y, wherein x is larger than or equal to 0 and smaller than 50, y is larger than or equal to 0 and smaller than 20, and Amino Acid is water-soluble amino acid. The preparation method comprises steps as follows: an alkaline solution of water-soluble amino acid and metallofullerene are mixed and subjected to a nucleophilic addition reaction, and thus the amino acid modified metallofullerene water-soluble nanoparticles are obtained. The nanoparticles can be dissolved in water, and the preparation method is simple and environment-friendly.

Description

technical field [0001] The invention relates to an amino acid-modified metallofullerene water-soluble nanoparticle and a preparation method and application thereof, belonging to the field of nanomaterials. Background technique [0002] Since the discovery of C by Kroto et al. in 1985 60 Since then, fullerenes have greatly promoted the development of nanotechnology. With the rapid development of fullerene industrial production and the emergence of nanotechnology based on fullerene materials, people have paid great attention to the effects of fullerene and its derivatives. Fullerenes and intercalated metallofullerenes are widely used in biomedical fields due to their unique structures and chemical and physical properties. Existing research results show that fullerenes / metallofullerenes have various properties such as antiviral effect, antioxidant activity and cytoprotective effect, antibacterial activity, drug / gene delivery carrier, magnetic resonance imaging and tumor growt...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/10A61K49/14A61K49/18
CPCA61K49/10A61K49/146A61K49/1824
Inventor 王春儒周悦甄明明
Owner BEIJING FUNAKANG BIOTECH CO LTD
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