Power frequency electromagnetic field generating device having tumor inhibiting effect and loading method

A technology of tumor suppression and generation device, which is applied in the interdisciplinary field of physics, biology and medicine, to achieve the effect of uniform magnetic field strength, inhibition of growth and metastasis, and promotion of cell autophagy

Pending Publication Date: 2017-05-10
ZHEJIANG UNIV +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Low-frequency magnetic fields can induce autophagy (see Marchesi N et al., 2014, Cellular Physiology), but how it affects the survival and death of tumor cells, as well as the specific molecular mechanism, have not yet been clearly understood

Method used

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  • Power frequency electromagnetic field generating device having tumor inhibiting effect and loading method
  • Power frequency electromagnetic field generating device having tumor inhibiting effect and loading method
  • Power frequency electromagnetic field generating device having tumor inhibiting effect and loading method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1, a kind of industrial frequency electromagnetic field generating device with tumor suppressing effect provided by the present invention, consists of an industrial frequency power supply 1, a first autotransformer 2 (alternating current AC), a second autotransformer 3 (direct current DC), The first diode bridge 4, the second diode bridge 5, the first group of coils 6, the second group of coils 7, the irradiation part 8, the voltage detection part 9, the magnetic field detection part 10, the temperature measurement part 11 and The terminal computer 12 is composed of a power frequency power supply 1 connected to one end of the first autotransformer 2 and the second autotransformer 3 respectively, and the other end of the first autotransformer 2 and the second autotransformer 3 are respectively connected to the first two poles The tube bridge 4 is connected with the second diode bridge 5, the other end of the first diode bridge 4 is connected with the first grou...

Embodiment 2

[0030] Example 2, the present invention acts on cultured Wilms tumor cell G401, using figure 1 and figure 2 device shown, according to the Figure 4 The program was used to treat the cells, each time the voltage was changed for 3.5 minutes, each round of action time was about 30 minutes in total, 4 rounds were treated every day, and the electromagnetic field irradiation time was 2 hours in total; the negative control group placed the cells between the coils that did not load the electromagnetic field The time is the same; the positive control is cisplatin (Jiangsu Hansoh Pharmaceutical Co., Ltd.), and the administration concentration is 500nM, once a day.

[0031] The specific implementation process is:

[0032] Cell line and culture method: Wilms tumor cell G401, which is an adherent cell, cultured in McCoy medium containing 10% fetal bovine serum in a 37°C incubator, containing 5% carbon dioxide and saturated water vapor;

[0033] Main equipment: power frequency electrom...

Embodiment 3

[0041] Example 3, the present invention acts on the cultured neuroblastoma cell CHLA255, using figure 1 and figure 2 device shown, according to the Figure 4 The program was used to treat the cells, each time the voltage was changed for 3.5 minutes, each round of action was about 30 minutes, 4 rounds were treated every day, and the electromagnetic field irradiation time was 2 hours in total; in the negative control group, the cells were placed between the coils without electromagnetic field loading. The same time was placed on the table; the positive control was cisplatin (Jiangsu Hansoh Pharmaceutical Co., Ltd.), the administration concentration was 500nM, and the administration was once a day.

[0042] The specific implementation process is:

[0043] Cell line and culture method: neuroblastoma cell CHLA255, which is an adherent cell, cultured in IMDM medium containing 10% fetal bovine serum in an incubator at 37°C, containing 5% carbon dioxide and saturated water vapor; ...

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Abstract

The invention provides a power frequency electromagnetic field generating device having a tumor inhibiting effect. The power frequency electromagnetic field generating device is composed of a power frequency power supply, two auto-transformers, two diode bridges, two groups of coils, a radiation part, a voltage detection part, a magnetic field detection part, a temperature measuring part and a terminal computer. According to the device, on the basis of the power frequency 50/60Hz power supply, voltage is continuously changed by virtue of the DC and AC auto-transformers, so that superposed static and alternating electromagnetic fields are generated in the radiation part. A loading method of the electromagnetic fields having the tumor inhibiting effect has a certain extensibility, the frequency is within a range of 30-300Hz, the intensity ratio of the static electromagnetic field to the alternating electromagnetic field is at 0.5-2.5 and total intensity is 1-10mT. The invention provides the special power frequency electromagnetic field generating device and the loading method; the generating device is reasonable in design, capable of acting on organisms, noninvasive and low in toxic and side effects, and the generating device has the obvious inhibiting effect on a plurality of tumors; and due to the action of the magnetic fields, the content of superoxide radicals in cells can be increased, and autophagy is promoted.

Description

technical field [0001] The invention belongs to the intersection fields of physics, biology and medicine, and relates to medical equipment, especially a therapeutic electromagnetic field for tumors. Background technique [0002] The frequency of low-frequency electromagnetic field is within 300 kilohertz (kHz). It has no thermal effect but has biological effect. The mechanism is still unknown, and it may be related to acting on charged macromolecules and changing their functional state. The tumor suppressive effect of magnetic fields has been widely reported (see Artacho-Cordón Francisco et al., 2013, Int J Mol Sci; Tofani S, 2015, Curr Topics in Med Chem). The European Union and the US FDA have approved tumor therapeutic magnetic field generating equipment (Novocure Company of Israel) is used for the clinical treatment of glioblastoma multiforme, and the technical feature is the use of a 100-300 kHz magnetic field (see US Patents US8019414, US8019414, US8406870). Chinese...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61N2/02A61N2/04
CPCA61N2/02
Inventor 陈希桑蒂托法尼袁林清石珂昕杨超卞苏琛王金湖朱坤杨敏顾伟忠尚世强李华美沈征王璨
Owner ZHEJIANG UNIV
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