A kind of immune cell cryopreservation solution for direct venous reinfusion and its application

A technology of immune cells and cryopreservation solution, applied in the field of biomedicine, can solve the problems of cumbersome cryopreservation process and subsequent application procedures, unsuitable for large-scale production, unclear composition of cryopreservation solution, etc., so as to facilitate clinical application and ensure safety. Good performance and effectiveness, good freezing effect
CN106665560BActive Publication Date: 2021-02-05中科赛洱生物科技(黑龙江)有限公司
5 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
中科赛洱生物科技(黑龙江)有限公司
Publication Date
2021-02-05
Patent Text Reader

Abstract

The invention discloses an immune cell cryopreservation liquid for direct intravenous reinfusion and application thereof. The present invention uses dimethyl sulfoxide, human serum albumin, dextran, hydroxyethyl starch, heparin sodium and other clinical pharmaceutical grade raw materials, and optimizes the ratio of the usage of each raw material to finally prepare a direct Immune cell cryopreservation fluid infused intravenously. In addition, the present invention also simplifies the operation steps and improves the freezing effect by optimizing the freezing storage method. On the one hand, the present invention avoids the potential risk of introducing animal-derived antigenic substances in the process of cell therapy; on the other hand, the immune cell cryopreservation effect of the present invention is better than conventional cryopreservation solutions, thus ensuring the safety and effectiveness of clinical use sex. The present invention preserves by two components, so that the cryopreservation solution can be stored stably for a long time. The method of the invention is simple to operate, provides stronger operability for the implementation of large-scale cryopreservation, and provides basic technical support for the implementation of immune cell therapy.
Need to check novelty before this filing date? Find Prior Art

Description

Technical field

[0001] The invention relates to a cell cryopreservation solution, in particular to a direct intravenous infusion of immune cell cryopreservation solution and an application method thereof. The invention belongs to the field of biomedicine technology.Background technique

[0002] Cancer is the primary problem that plagues human health. Cellular immunotherapy provides broad prospects for tumor prevention and treatment. However, in the process of clinical application, there are many problems such as difficulty in collecting autoimmune cells of some tumor patients, poor cell expansion, and difficulty in matching the time window of immune cells with other treatment methods. In addition, from the perspective of drug development and production, The off-site transportation, storage conditions and survival time of fresh immune cells are all limited. Therefore, the effective cryopreservation of immune cells provides the necessary basic technical support for the industrial applicatio...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More