Stable liposoluble nutrient microcapsules as well as preparation method and application thereof

Abstract

The invention discloses a preparation method and an application of stable liposoluble nutrient microcapsules. The method comprises the steps as follows: 1) an oil phase is subjected to spray granulation by a fluidized bed, and microcapsules coated with starch granules are formed; 2) the temperature is increased to a dry temperature, an alkali solution is added to the fluidized bed by spraying, so that starch and grease on the surfaces of the microcapsules are gelatinized and saponified at the same time, a compact protective film is formed, and the stable liposoluble nutrient microcapsules are obtained, wherein the oil phase is a grease solution or a grease dispersion liquid containing liposoluble nutrients and an antioxidant. The preparation method performs gelatinization and saponification under the flow dry condition simultaneously, a formed dual protection film containing gelatinized starch and saponified grease is more compact, and the microcapsules are more stable.

Description

technical field [0001] The invention belongs to the field of medicine and chemical industry, and in particular relates to a preparation method of stable fat-soluble nutrient microcapsules. Background technique [0002] The fat-soluble nutrients in the present invention mainly refer to fat-soluble vitamins and carotenoids. Vitamins are a type of trace organic regulatory substances that humans and animals must obtain from food in order to maintain normal physiological functions, and play an important role in the growth, metabolism, and development of the body; carotenoids are a type of important natural pigments In general, it can improve animal fecundity and immune function, and has various physiological functions such as anti-oxidation, coloring, and the ability to strengthen the connection and communication between cells and cell seams. Carotenoids and vitamins cannot be synthesized or synthesized in insufficient amounts in the body, and often need to be supplemented in an...

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Problems solved by technology

[0005] The above reports all have their own advantages, and also improve the stability of active substances to a certain extent, but their common shortcomings are: 1) there will be gaps and pores on the surface of microcapsules or adsorbents to protect The layer is not dense enough. During storage, transportation and secondary processing, oxygen enters and contacts vitamins and carotenoids along the gaps and pores, and side reactions are prone to occur and the content decreases; 2) The surface of microencapsulated products is There will be more or less core material residues, and direct use will inevitably cause the loss of this part of vitamins and carotenoids

[0006] CN201280019199.1 reported a method for preparing beads containing carotenoids. Beads are obtained by spraying and condensing high-melting point oils containing fat-soluble nutrients, but the dosage form is not rigid enough, and it is easily damaged during subsequent processing such as tableting, and The fat-soluble nutrients on the surface of the beads lack effective protective carriers, which will lead to the instability of fat-soluble nutrients

[0007] CN201380011311.1 and CN201480062474.7 are respectively processed by mixing and extruding fat-soluble nutrients with emulsified protective colloids or polymer materials, but these dosage forms have not formed effective protection for the fat-soluble nutrients on the surface

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