Multifunctional mesoporous carbon microsphere integrated with T1-T2 dual mode and preparation method thereof

A mesoporous carbon and multifunctional technology, applied in the field of multifunctional mesoporous carbon spheres and its preparation, can solve the problems of blood bone signal confusion and achieve the effect of wide application prospects

Active Publication Date: 2017-05-17
FUDAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there are some disadvantages of single mode imaging diagnostic technology, such as T 2 Weighted MRI images are dark signals, which are easily confused with blood and bone signals, and susceptibility artifacts will appear in addition

Method used

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  • Multifunctional mesoporous carbon microsphere integrated with T1-T2 dual mode and preparation method thereof
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  • Multifunctional mesoporous carbon microsphere integrated with T1-T2 dual mode and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0028] (1) Preparation of mesoporous carbon sphere precursor (phenolic resin / F127): 0.6 g of phenol was first melted in a water bath at 45 °C, then 15 mL of 0.1 M sodium hydroxide solution was added and stirred for 10 min. Then 2.1 mL of formaldehyde solution with a concentration of 37 wt% was added, and the above mixture was heated to 70 °C and stirred for 0.5 h to obtain a low molecular weight phenolic resin. Another weighed 0.96 g F127 was dissolved in 15 mL of water, and slowly poured into the solution after it was completely dissolved. The mixed solution was stirred at 66° C. for 2 hours, and then 50 ml of water was added to dilute the mixed solution, and the mixed solution was stirred at a speed of about 340 rpm for 16–18 hours. During the reaction, the color of the solution will change from colorless to pink and finally dark red, and there will be sediment at the bottom of the bottle. Stand still until the sediment is dissolved Take 17.7 mL of the reaction solution dil...

Embodiment 2

[0032] (1) Preparation of mesoporous carbon sphere precursor (phenolic resin / F127): 0.5 g of phenol was melted in a water bath at 45 °C, and then 12.5 mL of 0.1 M sodium hydroxide solution was added and stirred for 10 min. Then 1.9 mL of formaldehyde solution with a concentration of 37 wt% was added, and the above mixture was heated to 70 °C and stirred for 0.5 h to obtain a low molecular weight phenolic resin. Another weighed 0.82 gF127 was dissolved in 15 mL of water, and slowly poured into the solution after it was completely dissolved. The mixed solution was stirred at 66°C for 2 hours, and then 50 ml of water was added to dilute the mixed solution, and the mixed solution was stirred at a speed of about 340 rpm for 16-18 hours. During the reaction, the color of the solution will change from colorless to pink and finally dark red, and there will be sediment at the bottom of the bottle. Stand still until the sediment is dissolved Take 17.7 mL of the reaction solution dilute...

Embodiment 3

[0036] The mesoporous carbon sphere precursor phenolic resin / F127 was synthesized according to Example 1.

[0037] 9 mg {Fe 6 Gd 6 P 6} ([Fe 6 Gd 6 ( mu 3 -O) 2 (CO 3 )(O 3 PPh) 6 (O 2 C t Bu) 18 ]) ultrasonically dissolved in 2 ml tetrahydrofuran, 20 mg phenolic resin / F127 precursor was added to the solution, and ultrasonically dispersed in the tetrahydrofuran solution. The mixed solution was stirred and evaporated to dryness at room temperature to obtain {Fe 6 Gd 6 P 6} / phenolic resin / F127 composite material, put the material in a tube furnace, and bake it at 600°C for 3 hours under a nitrogen atmosphere to obtain iron oxide-gadolinium phosphate / mesoporous carbon pellets. Then the functionalized carbon pellets were roasted at 300° C. for 1 hour in an air atmosphere to obtain carboxylated iron oxide-gadolinium phosphate / mesoporous carbon pellets, namely image 3 shown.

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Abstract

The invention relates to the technical field of functional nanomaterials, and in particular to a multifunctional mesoporous carbon microsphere integrated with T1-T2 dual mode nuclear magnetic imaging and drug-loading property and a preparation method thereof. The multifunctional mesoporous carbon microsphere disclosed by the invention contains paramagnetic gadolinium phosphate as a T1 contrast agent and superparamagnetic iron oxide as a T2 contrast agent, the particles of the contrast agents are highly uniformly dispersed in the carbon skeleton of the mesoporous carbon microsphere, the mass content of gadolinium phosphate and iron oxide is 0.5 to 25 percent, and the particle size of gadolinium phosphate and iron oxide is 1nm to 10nm. In the process of preparing the multifunctional mesoporous carbon microsphere, an iron-gadolinium metal cluster is introduced into a precursor of the mesoporous carbon microsphere in one step, and the multifunctional mesoporous carbon microsphere is then prepared by one-step in-situ carbonization. The multifunctional mesoporous carbon microsphere realizes the integration of a T1-T2 dual mode contrast function and a drug-loading function, also has the characteristic of low cytotoxicity, realizes a diagnosis- and treatment-integrated function, and has a broad application prospect in clinical and basic medicine researches.

Description

technical field [0001] The invention relates to the technical field of functional nanomaterials, in particular to a collection of T 1 , T 2 Multifunctional mesoporous carbon spheres with integrated dual-mode nuclear magnetic imaging and drug-loading properties and a preparation method thereof. Background technique [0002] Composite functional nanomaterials, especially multifunctional materials integrating clinical diagnosis and therapeutic performance, have attracted more and more attention in the field of modern medical and basic medical research. The combination of diagnosis and treatment can improve the treatment effect in the early stage of the disease. Diagnostic technology can be used to detect diseases, and at the same time, drugs can be delivered to the diseased part, and the delivery and distribution of drugs can be detected in real time, so the dosage and treatment methods can be better adjusted and the occurrence of side effects can be reduced. [0003] Magnet...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/18A61K49/08A61K47/69A61K47/59A61K31/704A61P35/00C01B32/15C01B32/05B82Y30/00B82Y40/00
CPCA61K31/704A61K49/08A61K49/1857B82Y30/00B82Y40/00C01P2004/62C01P2004/64C01P2006/17
Inventor 凌云张倩倩邓名莉刘小锋杨永泰周亚明
Owner FUDAN UNIV
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