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A kind of hemostatic material and its preparation method and application

The technology of a hemostatic material and a silo, which is applied to the hemostatic material and its preparation, and the field of a hemostatic kit for preparing the hemostatic material, can solve the problems of slow wound healing, long dialysis purification time, low blood coagulation speed, etc., and achieve the wound healing speed. The effect of fast, short dialysis purification time and high blood coagulation speed

Active Publication Date: 2020-07-10
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Existing hemostatic materials have low coagulation speed, poor mechanical properties, long dialysis purification time, and slow wound healing after use

Method used

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  • A kind of hemostatic material and its preparation method and application
  • A kind of hemostatic material and its preparation method and application
  • A kind of hemostatic material and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0080] Example 1: A hemostatic material was prepared by using aldehyde-modified sodium hyaluronate, aldehyde-modified sodium alginate and amine-modified polyaspartic acid hydrazide.

[0081] (1) At 30°C, add 6.5g of sodium periodate to a 5% sodium alginate aqueous solution with a mass concentration of 6.5g, stir and react in the dark for 3 hours, then add ethylene glycol to terminate the reaction, perform ultrafiltration with an ultrafiltration cup, and freeze-dry to obtain Aldehyde-modified sodium alginate with a grafting rate of 30% and a molecular weight of 24700Da;

[0082] (2) At 30°C, add 7.5g of sodium periodate to a 5% hyaluronic acid aqueous solution, and stir the reaction in the dark for 3 hours, then add ethylene glycol to terminate the reaction, perform ultrafiltration with an ultrafiltration cup, and freeze-dry to obtain Aldehyde-modified sodium hyaluronate with a grafting rate of 30% and a molecular weight of 480,000 Da;

[0083] (3) Dissolve 4g of polysuccinimi...

Embodiment 2

[0085] Example 2: A hemostatic material was prepared by using aldehyde-modified sodium hyaluronate and aldehyde-modified sodium alginate and amine-modified polyaspartic acid hydrazide.

[0086] (1) At 30°C, add 7.5g of sodium periodate to a 5% sodium alginate aqueous solution with a mass concentration of 7.5g, stir and react in the dark for 3 hours, then add ethylene glycol to terminate the reaction, perform ultrafiltration with an ultrafiltration cup, and freeze-dry to obtain Aldehyde-modified sodium alginate with a grafting rate of 36% and a molecular weight of 18200Da;

[0087](2) At 30°C, add 8.5g of sodium periodate to a 5% hyaluronic acid aqueous solution, and stir the reaction in the dark for 3 hours, then add ethylene glycol to terminate the reaction, perform ultrafiltration with an ultrafiltration cup, and freeze-dry to obtain Aldehyde-modified sodium hyaluronate with a grafting rate of 36% and a molecular weight of 320,000 Da;

[0088] (3) Dissolve 4g of polysuccini...

Embodiment 3

[0090] Example 3: A hemostatic material was prepared by using aldehyde-modified sodium hyaluronate, aldehyde-modified sodium alginate and amine-modified polyaspartazide.

[0091] (1) At 30°C, add 8.5g of sodium periodate to a 5% sodium alginate aqueous solution with a mass concentration of 8.5g, stir and react in the dark for 3 hours, then add ethylene glycol to terminate the reaction, perform ultrafiltration with an ultrafiltration cup, and freeze-dry to obtain Aldehyde modified sodium alginate with a molecular weight of 9800Da;

[0092] (2) At 30°C, add 9.5g of sodium periodate to a 5% hyaluronic acid aqueous solution, and stir the reaction in the dark for 3 hours, then add ethylene glycol to terminate the reaction, perform ultrafiltration with an ultrafiltration cup, and freeze-dry to obtain Aldehyde-modified sodium hyaluronate with a grafting rate of 42% and a molecular weight of 230,000 Da;

[0093] (3) Dissolve 4g of polysuccinimide in 20mL of N,N-dimethylformamide, add...

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Abstract

The present invention relates to a bleeding stopping material and a preparation method thereof, wherein an aldehyde modified mixture formed from aldehyde modified sodium alginate and aldehyde modified sodium hyaluronate and an amino modified polyaspartic hydrazide are subjected to a Schiff base reaction to obtain the bleeding stopping material, the bleeding stopping material has characteristics of high coagulation rate and good mechanical property, the mechanical property can be up to 6000 Pa, the wound healing is rapid after the use of the bleeding stopping material, the fastest coagulation rate is 5 s, and the in vivo mouse naked eye wound area observation test results show that the coagulation rate of the bleeding stopping material is 3 days faster than the gauze and is 1 day faster than the commercial sodium alginate dressing. The present invention further provides a bleeding stopping kit, which has characteristics of simple use, high coagulation rate, and rapid wound healing after the use.

Description

technical field [0001] The invention belongs to the field of biological materials, and specifically relates to a hemostatic material, a preparation method and application thereof, and further specifically relates to a hemostatic material, a preparation method thereof, and a hemostatic kit for preparing the hemostatic material. Background technique [0002] Hemostatic materials have gone through several stages of development, from natural cotton and linen products to artificial polymer materials and then to natural polymer materials. Now more and more researchers are focusing on the modification of natural polymers, through modification, on the basis of retaining the original advantages of non-toxicity, environmental friendliness, good biocompatibility, and easy degradation, to enhance its For the ability to stop bleeding from wounds. [0003] The existing hemostatic materials have low coagulation speed, poor mechanical properties, long dialysis purification time, and slow w...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G81/00A61L24/04A61L24/00
CPCA61L24/0015A61L24/046A61L2300/412A61L2400/04C08G81/00C08L87/00
Inventor 谭天伟韦依曹辉史璐皎罗楠刘敏
Owner BEIJING UNIV OF CHEM TECH
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