A kind of platelet-rich plasma composition and preparation method thereof

A platelet-rich plasma and composition technology, which is applied in the field of platelet-rich plasma composition and its preparation, can solve the problems of slow effect, unnatural influence on normal life, etc., and achieve the improvement of whitening effect, improvement of dull facial expression, and improvement of whitening effect Effect

Active Publication Date: 2020-03-27
浙江卫未生物医药科技有限公司
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  • Claims
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Problems solved by technology

[0009] In the prior art, PRP can activate multiple cell pathways through cell activity factors, and gradually improve cells, which lasts for a long time, but the effect is slow; after botulinum toxin is used alone, it can play a role within 4 to 48 hours, and generally can maintain 3 ~6 months, if you want to maintain the effect, you need continuous injections, generally 3-4 injections within a year, and you need a long (1-2 months) recovery period after use, side effects such as stiffness, unnaturalness, etc. Great impact on life; natural tyrosinase inhibitors such as oxidized resveratrol are currently mainly used in oral health products, which need to be taken for a long time, and the effect is slow

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  • A kind of platelet-rich plasma composition and preparation method thereof
  • A kind of platelet-rich plasma composition and preparation method thereof

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preparation example Construction

[0033] A preparation method of platelet-rich plasma composition, comprising the steps of:

[0034] Step 1. Prepare platelet-rich plasma; dilute botulinum toxin with normal saline; dissolve natural tyrosinase inhibitor with a small amount of solvent and then dilute with normal saline, and filter to sterilize. Among them, the preparation method of platelet-rich plasma is as follows: under sterile conditions, divide 5-12mL of peripheral blood into PRP thixotropic separation gel extraction tubes, centrifuge at 1500-2000g for 8-12min, and the plasma on the upper layer of the thixotropic separation gel is Platelet-rich plasma; extracted platelet-rich plasma contains at least 300 x 10 9 cells / L platelets, RBC concentration less than 0.3×10 12 cells / L. Natural tyrosinase inhibitors include oxidized resveratrol, resveratrol, arbutin, or mulberryin.

[0035] Step 2. Mix the platelet-rich plasma in step 1, the botulinum toxin diluted with normal saline, and the natural tyrosinase inhi...

Embodiment 1

[0040] Select 10 female facial beautifiers, aged 21-60, with varying degrees of forehead lines, crow's feet, sagging facial skin, enlarged pores, pigmentation spots, dark circles, etc.

[0041] PRP preparation: Under sterile conditions, extract 9-12ml of venous peripheral blood from facial beautifiers, inject it into the extraction tube of PRP thixotropic separation gel, centrifuge at 1800g for 10min, and absorb 3-4ml of plasma on the upper layer of the separation gel. Table 1 shows the PRP extraction of 10 facial cosmetic subjects.

[0042] The obtained platelet-rich plasma was mixed with oxidized resveratrol at a concentration of 4mg / mL and botulinum toxin at a volume ratio of 25U / mL at a volume ratio of 3:1:1 to obtain 10 groups of 6ml platelet-rich plasma compositions. 2.4×10 8 —5.2×10 8 / mL, the final concentration of oxidized resveratrol was 0.8mg / mL, and the botulinum toxin was 5U / mL.

[0043] Inject the obtained 10 groups of platelet-rich plasma compositions on the ...

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Abstract

The invention discloses a platelet-rich plasma composition comprising the following components: platelet-rich plasma, botulinum toxin, and a natural tyrosinase inhibitor. The invention also discloses a preparation method and use method of the platelet-rich plasma composition. The platelet-rich plasma composition can retard side effects of the botulinum toxin after use, shortens the recovery period, and prolongs the effect duration time; at the same time, the absorption efficiency of the natural tyrosinase inhibitor such as oxyresveratrol is improved, and the whitening effect can be greatly improved. The beautifying composition combines three beautifying advantages of PRP, the botulinum toxin and the natural tyrosinase inhibitor such as oxyresveratrol, and the combined effect of the three components can produce quick-acting, intermediate-acting and long-term whitening and wrinkle-removing effects.

Description

technical field [0001] The invention relates to the technical field of cosmetic products, in particular to a platelet-rich plasma composition and a preparation method thereof. Background technique [0002] The skin is composed of epidermis, dermis, and subcutaneous tissue. It is an important part of maintaining human life and health. It covers the surface of the human body and directly contacts with the outside world. It is the first barrier of the body and is easily damaged by the environment. . Under the influence of human age growth and external environmental factors (such as stress response, pollution, ultraviolet rays, etc.), the skin will gradually show aging, and the skin function and appearance will decline. spots, wrinkles, and sagging skin. [0003] The formation of wrinkles is mainly due to internal reasons, somatic cell aging is the most fundamental cause of wrinkles in middle-aged and elderly people. This is the law of genetics. With age, cell activity gradua...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/98A61K8/64A61K8/60A61K8/34A61Q19/08A61Q19/02
CPCA61K8/345A61K8/347A61K8/602A61K8/64A61K8/983A61K2800/592A61K2800/782A61K2800/91A61Q19/02A61Q19/08
Inventor 陈锦阳邓兆群李佳佳
Owner 浙江卫未生物医药科技有限公司
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