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Traditional Chinese medicinal composition for preventing and treating infectious bronchitis of chickens

A technology for bronchitis and chicken infectivity, which is applied in the directions of drug combination, pharmaceutical formula, plant raw materials, etc., can solve problems such as high cost and time-consuming, and achieve the effects of quick effect, water-reducing and swelling-reducing effect, and simple preparation method.

Inactive Publication Date: 2017-05-24
LUOYANG HUIZHONG ANIMAL MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it uses a large number of traditional Chinese medicines, with a total of 9 flavors. In addition, its preparation process uses drying and crushing to obtain granules, which is not only time-consuming, but also costly.

Method used

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  • Traditional Chinese medicinal composition for preventing and treating infectious bronchitis of chickens
  • Traditional Chinese medicinal composition for preventing and treating infectious bronchitis of chickens
  • Traditional Chinese medicinal composition for preventing and treating infectious bronchitis of chickens

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1 screens the preparation of optimal extraction process condition and Chinese medicine composition powder of the present invention

[0024] 1. Orthogonal test to screen the best extraction process conditions

[0025] The amount of solvent, extraction time and extraction times can all affect the extraction effect. Take these three items as factors, take three levels each, and carry out L 9 (3 4 ) Orthogonal test to screen the best process conditions. The content of syringin and glycyrrhizinic acid were selected as evaluation indicators for comprehensive evaluation, as shown in Table 1 below.

[0026] Table 1 Orthogonal test factor table

[0027]

[0028] Acanthopanax licorice was extracted according to the orthogonal test design table, and the specific operation steps were as follows:

[0029] Using the reflux extraction method, Acanthopanax, Glycyrrhizae, and Campanulaceae were added in a ratio of 2:2:1, 50g of Acanthopanax, 50g of Glycyrrhizae, and 2...

Embodiment 2

[0042] Embodiment 2 screens the preparation of optimal purification process condition and Chinese medicine composition granule of the present invention

[0043] 1. Determination of purification conditions

[0044] The extraction was carried out according to the extraction process of Acanthopanax licorice and Platycodon grandiflorum determined in Example 1. Then the extract of Acanthopanax licorice and Platycodon grandiflorum was purified.

[0045] The extract contains more impurities such as protein, fruit acid, and mucus, which affect the granulation process, so the extract needs to be purified. Take 25kg of the extract obtained by extracting according to the optimal extraction conditions, concentrate to a relative density of 1.20 (70°C), and divide it into 2 parts, each 12.5kg. Add ethanol respectively to make the alcohol content 80% and 60%, stand at 4°C for 12 hours, filter, take the supernatant to recover ethanol, filter, concentrate, and set the volume to 10L, detect t...

Embodiment 3

[0062] Embodiment 3 Chinese medicine composition powder of the present invention, the prevention and treatment experiment of granule

[0063] 1 test material

[0064] 1.1 Drugs and reagents

[0065] The Chinese medicine composition powder prepared by embodiment 1

[0066] The Chinese medicine composition granule prepared by embodiment 2

[0067] Yinhuangbanqiaosan: batch number 20140501, packaging specification, 100g / bag, Harbin Zhongjing Biotechnology Co., Ltd., valid until May 2016.

[0068] 1.2 Virus strains and experimental animals

[0069] Infectious bronchitis virus M41E4 (strain number: CVCC-AV1511) was purchased from China Veterinary Drug Control Institute.

[0070] 550 SPF breeding eggs: purchased from Jinan Spafasi Poultry Co., Ltd.

[0071] The 1-day-old chicks were hatched from SPF eggs until they hatched. They were raised in the isolator in the experimental animal room of Pulaike Bioengineering Co., Ltd., fed with full-price feed without antibiotics, conventi...

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Abstract

The invention provides a traditional Chinese medicinal composition for preventing and treating infectious bronchitis of chickens. The raw materials of the traditional Chinese medicinal composition comprise acanthopanax root, liquorice and platycodon grandiflorum, wherein the ratio of the liquorice to the platycodon grandiflorum is 2:1; the ratio of the acanthopanax root to the liquorice to the platycodon grandiflorum is 4:2:1 to 1:2:1. The traditional Chinese medicinal composition provided by the invention can effectively prevent and treat the infectious bronchitis of the chickens, has remarkable effects of preventing weight reduction of the chickens and relieving respiratory symptom, and has the characteristics of quick response, accurate curative effect, no medicinal residues and no toxic or side effect. The invention further provides a preparation method of the traditional Chinese medicinal composition. The preparation method of the traditional Chinese medicinal composition is simple in process and suitable for the requirement of large-scale industrialized production.

Description

technical field [0001] The invention belongs to the field of veterinary traditional Chinese medicine, in particular to a traditional Chinese medicine composition for preventing and treating chicken infectious bronchitis. Background technique [0002] Chicken infectious bronchitis (Infectious Bronchitis, IB) is an acute infectious disease of chickens caused by chicken infectious bronchitis virus (Infectious Bronchitis Virus, IBV), and is one of the important diseases in intensive chicken farms. IBV mainly affects the respiratory system, genitourinary system and digestive system of chickens, causing symptoms such as dyspnea, rales, coughing, sneezing, kidney lesions, urate deposition, and decreased egg production in sick chickens. After infection with infectious bronchitis virus, the death rate of chickens increases, the feed conversion rate decreases, and the cost of breeding increases, which brings serious harm to chicken production. [0003] Infectious bronchitis virus bel...

Claims

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Application Information

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IPC IPC(8): A61K36/484A61P11/00A61P31/14
Inventor 张许科刘兴金潘贵珍
Owner LUOYANG HUIZHONG ANIMAL MEDICINE
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