Unlock instant, AI-driven research and patent intelligence for your innovation.

Bone cement and preparation method for same

A technology of bone adhesive and chitosan, which is applied in the field of medical materials, can solve the problems of normal tissue burns, sudden drop in blood pressure, and there is no bone adhesive product, and achieve the effect of improving adhesion and compressive strength

Inactive Publication Date: 2017-05-24
SUZHOU AIBOMAIER NEW MATERIAL CO LTD
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the cytotoxicity of its monomers, there may be a sudden drop in blood pressure during the operation. At the same time, the thermal effect generated during curing is likely to cause burns to normal tissues. In addition, it is not suitable for bone bonding because it cannot be degraded.
For now, there is no clinically satisfactory bone adhesive product

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] A bone cement prepared from the following ingredients in parts by weight: 10 parts of magnesium phosphate, 13 parts of citric acid, 0.6 parts of chitosan, 2 parts of guar gum, 5 parts of soybean protein isolate, and dewaxed shellac resin 5 parts, 0.25 parts of sodium carbonate, 3 parts of silicon dioxide, 15 parts of calcium carbonate, 1.4 parts of chopped viscose-based carbon fiber, 10 parts of glycerin, and 60 parts of ultrapure water.

[0019] The preparation method of the above-mentioned bone cement is: (1) Weigh citric acid and add 10 times the weight of ultrapure water, stir at room temperature for 30 minutes, add chitosan, and stir at room temperature for 18 hours until the chitosan is fully dissolved , to obtain a uniform citric acid chitosan solidified solution, sealed and stored at low temperature for later use; (2) Sodium carbonate was dissolved in 100 times the weight of ultrapure water, and at 50°C, the lac resin was dissolved in the sodium carbonate solutio...

Embodiment 2

[0021] A bone cement prepared from the following components by weight: 40 parts of magnesium phosphate, 18 parts of citric acid, 2 parts of chitosan, 5 parts of guar gum, 2 parts of soybean protein isolate, and dewaxed shellac resin 10 parts, 0.55 parts of sodium carbonate, 10 parts of silicon dioxide, 30 parts of calcium carbonate, 3.2 parts of chopped viscose-based carbon fiber, 5 parts of glycerin, and 140 parts of ultrapure water.

[0022] The preparation method of the above-mentioned bone cement is: (1) Weigh citric acid and add 10 times the weight of ultrapure water, stir at room temperature for 30 minutes, add chitosan, and stir at room temperature for 30 hours until the chitosan is fully dissolved , to obtain a uniform citric acid chitosan solidified solution, sealed and stored at low temperature for later use; (2) Sodium carbonate was dissolved in 100 times the weight of ultrapure water, and at 60°C, the lac resin was dissolved in the sodium carbonate solution , stirr...

Embodiment 3

[0024] A bone cement, prepared from the following components by weight: 20 parts of magnesium phosphate, 15 parts of citric acid, 0.8 parts of chitosan, 4 parts of guar gum, 3 parts of soybean protein isolate, and dewaxed shellac resin 5 parts, 0.25 parts of sodium carbonate, 8 parts of silicon dioxide, 25 parts of calcium carbonate, 1.8 parts of chopped viscose-based carbon fiber, 9 parts of glycerin, and 80 parts of ultrapure water.

[0025] The preparation method of the above-mentioned bone cement is: (1) Weigh citric acid and add 10 times the weight of ultrapure water, stir at room temperature for 30 minutes, add chitosan, and stir at room temperature for 24 hours until the chitosan is fully dissolved , to obtain a uniform citric acid chitosan solidified solution, sealed and stored at low temperature for later use; (2) Sodium carbonate was dissolved in 100 times the weight of ultrapure water, and at 55°C, the lac resin was dissolved in the sodium carbonate solution , stir ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
particle diameteraaaaaaaaaa
lengthaaaaaaaaaa
Login to View More

Abstract

The invention provides bone cement and a preparation method for the same. The preparation method comprises the following steps: (1) preparing citric acid chitosan solidification liquid, and sealing and storing the citric acid chitosan solidification liquid at low temperature; (2) preparing a lac resin solution; (3) ball-milling magnesium phosphate, a silicon dioxide and calcium carbonate into powder to obtain a mixture for later use; (4) sequentially adding guar gum, an isolated soybean protein and glycerin into left ultrapure water for uniform stirring, sequentially and slowly adding the citric acid chitosan solidification liquid and the lac resin solution into an obtained solution, finally adding the mixture prepared by step (3) and chopped rayon-based carbon fibers, and performing ultrasonic treatment at room temperature to obtain the bone cement. The bone cement has high bonding performance, and the clinical application requirement is met.

Description

technical field [0001] The invention relates to the field of medical materials, in particular to a bone cement and a preparation method thereof. Background technique [0002] With the development of modern high-speed transportation and the aggravation of the aging population, fractures are becoming more and more common clinically. The method of surgical treatment of fractures is mainly open reduction, with metal internal or external fixation such as micro-plate screw fixation, intramedullary nail fixation, intraosseous nylon suture fixation and intraosseous steel wire suture fixation. However, for fractures in some special parts, such as comminuted fractures or intra-articular fractures around the joints and calcaneus, it is often impossible to accurately splice, reduce and fix the fracture fragments due to the lack of effective internal fixation materials. Traditional clinical treatment advocates removing or setting aside some unfixable small bone fragments, but for non-in...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/02A61L24/08A61L24/10A61L24/04
CPCA61L24/02A61L24/046A61L24/08A61L24/108C08L5/08C08L5/00C08L89/00C08L67/04
Inventor 李子寅
Owner SUZHOU AIBOMAIER NEW MATERIAL CO LTD