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Self-moisture-absorption cold-forming polyvinyl chloride composite material for packaging drugs and preparation method of self-moisture-absorption cold-forming polyvinyl chloride composite material

A polyvinyl chloride and composite material technology, applied in the field of pharmaceutical packaging, can solve the problems of small bubbles and can not put desiccant, etc., and achieve the effects of improving hygroscopicity, reasonable composition and strong reactivity

Active Publication Date: 2017-05-24
真美包装科技泰州有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the stamped bubbles of medicinal cold stamping materials are relatively small, generally about the size of a tablet, and no desiccant can be placed inside.
Putting a desiccant on the outside has no effect at all

Method used

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  • Self-moisture-absorption cold-forming polyvinyl chloride composite material for packaging drugs and preparation method of self-moisture-absorption cold-forming polyvinyl chloride composite material
  • Self-moisture-absorption cold-forming polyvinyl chloride composite material for packaging drugs and preparation method of self-moisture-absorption cold-forming polyvinyl chloride composite material
  • Self-moisture-absorption cold-forming polyvinyl chloride composite material for packaging drugs and preparation method of self-moisture-absorption cold-forming polyvinyl chloride composite material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Add 60g of phosphate methacrylate, 30g of 2-hydroxyethyl acrylate, and 50g of N-methylolacrylamide into the container, and react at 90°C for 2 hours; then add 10g of benzimidazole, 30g of polyamide wax, ℃ for 1 hour; then add 45g of nano-titanium dioxide and 140g of sodium alginate, and react at 140°C for 0.5 hours; naturally cool to obtain a modified product; the above modified product, 1000g of polyvinyl chloride resin, 80g of polyetherimide resin and adding 30g of ytterbium fluoride into a screw extruder for mixing and extruding to obtain polyvinyl chloride composite particles; the above polyvinyl chloride composite particles are calendered to obtain self-hygroscopic cold stamping polyvinyl chloride composite materials for pharmaceutical packaging.

[0031] When calendering, use a four-roller calender, the two-roller refining temperature is 165-170 ° C, the refining time is 12-15 minutes; the calendering temperature is 202-205 ° C, the calendering speed is 8.5-11 m / mi...

Embodiment 2

[0033] Add 80g of phosphate methacrylate, 30g of 2-hydroxyethyl acrylate, and 70g of N-methylolacrylamide into the container in sequence, and react at 90°C for 2 hours; then add 15g of benzimidazole and 15g of polyamide wax, ℃ for 1 hour; then add 45g of nano-titanium dioxide and 140g of sodium alginate, and react at 140°C for 0.5 hours; naturally cool to obtain a modified product; the above modified product, 1000g of polyvinyl chloride resin, 100g of polyetherimide resin and adding 30g of ytterbium fluoride into a screw extruder for mixing and extruding to obtain polyvinyl chloride composite particles; the above polyvinyl chloride composite particles are calendered to obtain self-hygroscopic cold stamping polyvinyl chloride composite materials for pharmaceutical packaging.

[0034] When calendering, use a four-roller calender, the two-roller refining temperature is 165-170 ° C, the refining time is 12-15 minutes; the calendering temperature is 202-205 ° C, the calendering spee...

Embodiment 3

[0036] Add 70g of phosphate methacrylate, 40g of 2-hydroxyethyl acrylate, and 60g of N-methylolacrylamide into the container in turn, and react at 90°C for 2 hours; then add 12g of benzimidazole and 22g of polyamide wax, ℃ for 1 hour; then add 50g of nano-titanium dioxide and 120g of sodium alginate, and react at 140°C for 0.5 hours; naturally cool to obtain a modified product; the above modified product, 1000g of polyvinyl chloride resin, 90g of polyetherimide resin and adding 35g of ytterbium fluoride into a screw extruder for mixing and extruding to obtain polyvinyl chloride composite particles; the above polyvinyl chloride composite particles are calendered to obtain self-hygroscopic cold stamping polyvinyl chloride composite materials for pharmaceutical packaging.

[0037] When calendering, use a four-roller calender, the two-roller refining temperature is 165-170 ° C, the refining time is 12-15 minutes; the calendering temperature is 202-205 ° C, the calendering speed is ...

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Abstract

The invention discloses a self-moisture-absorption cold-forming polyvinyl chloride composite material for packaging drugs, and a preparation method of the self-moisture-absorption cold-forming polyvinyl chloride composite material. The preparation method comprises the following steps: successively adding an acylate-phosphate compound, an acrylate active monomer and N-hydroxymethyl acrylamide into a container, and reacting for 2 hours at 90 DEG C; adding benzimidazole and polyamide wax, and reacting for one hour at 120 DEG C; adding nano titanium dioxide and sodium alginate, and reacting for 0.5 hour at 140 DEG C; naturally cooling to obtain a modifier; mixing the modifier, polyvinyl chloride resin, polyetherimide resin and ytterbium fluoride in a screw extruder, and extruding to obtain polyvinyl chloride composite particles; and performing calendaring molding on the polyvinyl chloride composite particles to obtain the self-moisture-absorption cold-forming polyvinyl chloride composite material for packaging the drugs. The self-moisture-absorption cold-forming polyvinyl chloride composite material solves the problems that the existing polyvinyl chloride transparent membrane is poor in adhesion and low in moisture absorption rate, can meet the requirement of the drug packaging industry and facilitates the prolonging of the drug quality guarantee period.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical packaging, and in particular relates to a self-moisture-absorbing cold stamping polyvinyl chloride composite material for pharmaceutical packaging and a preparation method thereof. Background technique [0002] The packaging of solid preparations in the domestic pharmaceutical industry is currently the most widely used aluminum-plastic blister packaging. It heats the pvc hard sheet, blows it, fills it with medicine, and then heat seals it with aluminum foil. This kind of packaging is convenient to carry and take, and is deeply loved by patients. However, due to the insufficient barrier properties of the PVC hard sheet, the maximum shelf life of the medicine in this package is no more than two years. Therefore, since 2000, a new type of packaging has been reported, that is, cold stamping packaging, also known as hard double aluminum packaging, commonly known as cold stamping aluminum. It ...

Claims

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Application Information

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IPC IPC(8): C08L27/06C08L79/08C08L5/04C08L77/00C08K13/02C08K3/22C08K5/101C08K5/521C08K5/20
CPCC08J5/18C08J2327/06C08J2479/08C08K2201/003C08K2201/011C08L27/06C08L2201/10C08L2203/162C08L2205/035C08L79/08C08L5/04C08L77/00C08K13/02C08K2003/2241C08K5/101C08K5/521C08K5/20
Inventor 李永山李永华李佳明李永青杨华张小元李佳昊
Owner 真美包装科技泰州有限公司
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