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Production method for methyl aspartate

A technology of aspartate methyl ester and production method, applied in chemical instruments and methods, preparation of organic compounds, organic chemistry and other directions, can solve the problems of high cost, low yield, poor product quality and the like, and achieve finished products. The effect of high yield and simple production process

Inactive Publication Date: 2017-05-31
XINYI HANLING BIO ENG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The product aspartic acid methyl ester that the present invention produces is the intermediate of producing asparagine, and its quality directly affects the yield and the quality of aspartic acid methyl ester, and the esterification method of traditional aspartic acid methyl ester is in aspartic acid In the acid methanol solution, excessive hydrogen chloride gas is passed into, and the esterification is completed at low temperature. This production method has the following defects: 1. hydrogen chloride gas is volatile, and the production environment is poor; 2. harsh conditions, poor control and easy output of dimethyl ester, Further reaction into polymers; 3. High cost and high energy consumption; 4. Low yield; 5. Product quality cannot be improved

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Sulfuric acid with a concentration of 30% is sent into the first stirring tank, and then pharmaceutical-grade aspartic acid powder is added. The weight ratio of the two raw materials is: a concentration of 30% sulfuric acid: aspartic acid powder=4.5:5.5, Stir and react at room temperature for 2.1 hours to obtain a solid-liquid mixture of aspartic acid sulfate, send the solid-liquid mixture of aspartic acid sulfate to a filter to filter out the liquid Part of it is discharged and recovered, and the obtained solid, that is, aspartic acid sulfate, is sent to the second stirring tank. Add methanol solution and solid acid to the second stirring tank, the ratio of the three raw materials is aspartic acid sulfate: methanol solution: solid acid = 4.98: 4.99: 0.03, stir the reaction at room temperature, add sulfuric acid while stirring Control the pH value of the reaction solution at 1.2, stir and react for 6 hours to obtain a solid-liquid mixture of methyl aspartate, send it to...

Embodiment 2

[0019] Concentration is that the chemically pure sulfuric acid of 30% is sent in the first mixing tank, then adds pharmaceutical grade aspartic acid powder, the weight ratio of two kinds of raw materials is: concentration is the sulfuric acid of 30%: aspartic acid powder=5.0: 5.0, after stirring and reacting for 2.2 hours at normal temperature, a solid-liquid mixture of aspartic acid sulfate was obtained, and the solid-liquid mixture of aspartic acid sulfate was sent to a filter for filtration. Remove the liquid part and discharge it for recovery, and the obtained solid, that is, aspartic acid sulfate, is sent to the second stirring tank. Add methanol solution and solid acid to the second stirring tank, the ratio of the three raw materials is aspartic acid sulfate: methanol solution: solid acid = 4.985: 4.985: 0.03, stir the reaction at room temperature, add sulfuric acid while stirring Control the pH value of the reaction solution at 1.3, stir and react for 6.5 hours to obtai...

Embodiment 3

[0021] Concentration is that the chemically pure sulfuric acid of 30% is sent in the first mixing tank, then adds pharmaceutical grade aspartic acid powder, the weight ratio of two kinds of raw materials is: concentration is the sulfuric acid of 30%: aspartic acid powder=5.5: 4.5. After stirring and reacting at room temperature for 2.3 hours, the solid-liquid mixture of aspartic acid sulfate was obtained, and the solid-liquid mixture of aspartic acid sulfate was sent to a filter for filtration. Remove the liquid part and discharge it for recovery, and the obtained solid, that is, aspartic acid sulfate, is sent to the second stirring tank. Add methanol solution and solid acid to the second stirring tank, the ratio of the three raw materials is aspartic acid sulfate: methanol solution: solid acid = 4.99: 4.98: 0.03, stir the reaction at room temperature, add sulfuric acid while stirring Control the pH value of the reaction solution at 1.4, stir and react for 6-7 hours to obtain ...

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PUM

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Abstract

The invention discloses a production method for methyl aspartate, belonging to the field of production of amino acids. According to the production method, methyl aspartate is prepared from aspartic acid powder, sulfuric acid with a concentration of 30%, solid acid and a methanol solution through production of sulfate of aspartic acid at first and esterification next. The production method has the advantages of usage of universal equipment, simple production process, no high-temperature and high-pressure reaction, environmental protection, high product output and capacity of producing a high-purity finished methyl aspartate product; and the finished methyl aspartate product is an intermediate for production of asparagine.

Description

[0001] Technical field: [0002] The invention belongs to the field of amino acid production, and in particular relates to a production method of methyl aspartate. [0003] Background technique: [0004] Asparagine is a drug with a molecular formula of C4H8N2O3, a molecular weight of 132.12, and a melting point of 234-235°. It often exists as a monohydrate and is a rhombohedral crystal. Bronchodilator, anti-peptic ulcer and gastric dysfunction, intravenous injection can cause blood pressure drop, peripheral vasodilation, increased cardiac contractility, slow heart rate and increased urine output, can prevent oral administration of acetyl salicyl in pyloric ligated rats Gastric mucosal damage caused by acid, animal experiments have shown that it has a significant antitussive effect and a certain anti-asthma effect, and can also be used for microbial culture, sewage treatment of acrylonitrile, etc. [0005] The product aspartic acid methyl ester that the present invention produc...

Claims

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Application Information

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IPC IPC(8): C07C227/18C07C229/24
Inventor 陈士安
Owner XINYI HANLING BIO ENG
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