Preparation method of vinblastine derivative

A technology of vinblastine and its derivatives, which is applied in the field of preparation of nordehydrovinblastine, can solve problems such as low yield, and achieve the effects of simplifying reaction steps, facilitating industrial production, and easy operation
CN106749342AActive Publication Date: 2017-05-31河南绿园药业有限公司
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
河南绿园药业有限公司
Publication Date
2017-05-31

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Abstract

The invention relates to a preparation method of a vinblastine derivative. The preparation method comprises the following steps of under the effect of ferric sulfate and peroxide formic acid, a compound shown as the formula A is coupled with vindoline; then, a reducing agent is added for performing reduction reaction to obtain the navelbine through preparation. The preparation method has the advantages that the yield is high; the purity of the obtained product is very high.
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Description

technical field

[0001] The invention relates to the preparation of a vinblastine derivative, in particular to a preparation method of nordehydrovinblastine. Background technique

[0002] Periwinkle is an important medicinal plant of the genus Oleander periwinkle. It is native to South Asia, the east coast of Africa and tropical America. It is a light-loving plant that likes warmth and chills, and is suitable for growing in a slightly dry and sunny environment. . The extraction of biologically active alkaloids from periwinkle has been going on for nearly a century, and the research on the extracted alkaloids as anticancer drugs has a history of many years.

[0003] Vinblastine has good anti-tumor activity, but its toxic and side effects are large, and its derivative nordehydrovinblastine is developed and listed (drug name Vinorelbine Tartrate).

[0004] After retrieval, the preparation method of nordehydrovinblastine is basically to obtain dehydrovinblastine first, and then...

Claims

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