Simulation system for simulating fracture healing process

A simulation system and fracture healing technology, applied in the field of biomedical engineering, can solve the problems that there is no deterministic relationship between mechanical factors, cell differentiation, changes in callus shape and size, and oversimplification of models and biological materials. Achieve the effects of avoiding humanitarian controversy, reducing biological experiments, and reducing delayed healing
CN106777584AInactive Publication Date: 2017-05-31HARBIN UNIV OF SCI & TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
HARBIN UNIV OF SCI & TECH
Publication Date
2017-05-31
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a simulation system for simulating a fracture healing process, which relates to the field of biochemical engineering. The simulation system is used for predicting the complex process of fracture healing and providing guidance for doctors in establishing a good surgical program for fracture healing. The system comprises a three-dimensional geometric modeling module, a finite element creation module, a fracture site biomechanical-modeling module, a fracture site cell evolution modeling module, a callus growth modeling module and a display module. Cell concentration and tissue material properties are updated by the fracture site biomechanical-modeling module and the fracture site cell evolution modeling module; the geometric shape of callus is updated by the callus growth modeling module; and the effect of fracture healing is judged by the display module. The simulation system can more accurately simulate the process of fracture healing and repetitively carry out experimental simulation for unlimited times, thus providing help for making the best surgical program for fracture healing.
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Description

technical field

[0001] The invention relates to the field of biomedical engineering, in particular to a simulation system for simulating the fracture healing process. Background technique

[0002] The musculoskeletal system plays an important role in the human body, and its main functions include: motor function, protective function, support function, hematopoietic function, and storage function. The high incidence of fractures, the pain caused by fractures to patients and the economic burden on society make the study of fracture healing particularly urgent and important. Although the research on fracture healing has been paid much attention, there are still 5% to 10% of fractures with delayed union or even nonunion due to various reasons.

[0003] Fracture healing is a complex process, including migration, proliferation, differentiation and apoptosis of bone marrow mesenchymal stem cells. Bone marrow mesenchymal stem cells differentiate into fibroblasts, chondrocytes, and...

Claims

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