Gongyanping vaginal drug delivery semisolid preparation, preparation method and application thereof

A vaginal administration, semi-solid technology, applied in the field of medicine, can solve the problems of restricting wide application, irritation of gastric mucosa, drug effect destruction, etc., and achieve high bioavailability, less irritation, and strong pertinence

Inactive Publication Date: 2017-06-06
贵州健瑞安药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Now on the market, Gongyanping Capsules, Gongyanping Tablets, Gongyanping Dispersible Tablets, Gongyanping Dropping Pills, Gongyan Ping oral liquid, Gongyanping granules, etc. are all oral dosage forms, and there are defects such as that the drug effect is destroyed by the first-pass action of the liver, the

Method used

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Examples

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preparation example Construction

[0045] The embodiment of the present invention also provides a preparation method of Gongyanping semi-solid preparation for vaginal administration, which includes the following steps:

[0046] Preparation of S1 Gongyanping dry extract powder:

[0047] S101 Decoction: Take Diren, Liangmianzhen, Angelica, Wuzhi Maotao, and Chuanposhi five flavors of traditional Chinese medicine decoction pieces, add water to decoct 2 to 4 times, each time for 1 to 2 hours, and the amount of water added each time is 6 to 10 times the weight of the medicinal materials , filter the decoction, combine the filtrate, and set aside. Among them, the Chinese medicine decoction pieces are dried whole herbs of traditional Chinese medicine, and the weight ratio of Diren decoction pieces, Liangmianzhen decoction pieces, Angelica decoction pieces, Wuzhi Maotao decoction pieces and Chuanposhi decoction pieces is 8-10:3-4:2.2-3:2:2.2-3 , preferably 45:17:14:10:14.

[0048] S102 Concentration and alcohol preci...

Embodiment 1

[0065] This embodiment provides a Gongyanping vaginal suppository, which is prepared by the following preparation method:

[0066] Take 450g of Diren decoction pieces, 170g of Liangmianzhen decoction pieces, 140g of Angelica decoction pieces, 100g of Wuzhi Maotao decoction pieces, 140g of Chuanposhi decoction pieces, and five traditional Chinese medicines. Decoct 3 times, the first time for 2 hours, the second time for 2 hours, the third time 1 hour, adding water each time is 10 times the weight of the medicinal materials, filtering the decoction, combining the filtrates, and concentrating under reduced pressure at 70°C to form an extract with a relative density of 1.25. Add absolute ethanol until the ethanol content therein reaches 50%, and let it stand for 24 hours to obtain a medicinal solution. Filter the medicinal liquid, recover ethanol under reduced pressure, and concentrate to a thick paste (55-60° C.) with a relative density of 1.32-1.36. The thick paste was dried in...

Embodiment 2

[0093] This embodiment provides a Gongyanping vaginal suppository, which is prepared by the following preparation method:

[0094] Take 450g of Diren decoction pieces, 170g of Liangmianzhen decoction pieces, 140g of Angelica decoction pieces, 100g of Wuzhi Maotao decoction pieces, 140g of Chuanposhi decoction pieces, and five traditional Chinese medicines. Decoct 3 times, the first time for 2 hours, the second time for 2 hours, the third time 1 hour, adding water each time is 10 times the weight of the medicinal materials, filtering the decoction, combining the filtrates, and concentrating under reduced pressure at 65°C to form an extract with a relative density of 1.25. When the temperature of the extract drops to about 25°C, Add absolute ethanol until the ethanol content therein reaches 50%, and let it stand for 24 hours to obtain a medicinal solution. Filter the medicinal liquid, recover ethanol under reduced pressure, and concentrate to a thick paste (55-60° C.) with a rel...

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Abstract

The invention provides a Gongyanping vaginal drug delivery semisolid preparation, a preparation method and the application thereof, and relates to the technical field of medicines. During the process of preparing the Gongyanping vaginal drug delivery semisolid preparation, extracts of five traditional Chinese medicines of melastoma dode candrum lour, radix zanthoxyli, angelica sinensis, radix fici simplicissimae and cudrania cochinchinensis are purified and dried in a vacuum state to prepare Gongyanping dry extract powder; a problem that traditional Chinese medicine extract is easy to stick is solved, the quality of the Gongyanping dry extract powder is more stable and the Gongyanping dry extract powder is suitable for mass production; a vaginal drug matrix is added to the Gongyanping dry extract powder; the finally prepared Gongyanping vaginal suppository or Gongyanping vaginal gel is applied to preparations of drugs for treating pelvic inflammatory diseases. The Gongyanping vaginal drug delivery semisolid preparation can directly act upon affected parts by using a vaginal drug delivery mode and has the advantages of high target property, small irritation, fast working and high biological availability.

Description

technical field [0001] The invention relates to the technical field of medicine, and in particular to a semi-solid preparation of Gongyanping for vaginal administration, a preparation method and application thereof. Background technique [0002] Pelvic inflammatory disease, including endometritis, salpingo-oophoritis, pelvic peritonitis, pelvic connective tissue inflammation and pelvic abscess, is a frequently occurring disease in women. Acute pelvic inflammatory disease refers to the acute inflammation of the female internal genitalia and its surrounding connective tissue and pelvic peritoneum, which is limited to one part or several parts at the same time; chronic pelvic inflammatory disease refers to the inflammation of the female internal genitalia and its surrounding connective tissue and pelvic peritoneum. Chronic inflammation. In modern western countries, 1% of women aged 15 to 30 suffer from acute or chronic pelvic inflammatory disease, and the incidence rate of wom...

Claims

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Application Information

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IPC IPC(8): A61K36/758A61K9/02A61K9/06A61K47/14A61K47/32A61P15/00A61P15/02
Inventor 张珍王雪孙立新
Owner 贵州健瑞安药业有限公司
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