Gongyanping vaginal drug delivery semisolid preparation, preparation method and application thereof

Abstract

The invention provides a Gongyanping vaginal drug delivery semisolid preparation, a preparation method and the application thereof, and relates to the technical field of medicines. During the process of preparing the Gongyanping vaginal drug delivery semisolid preparation, extracts of five traditional Chinese medicines of melastoma dode candrum lour, radix zanthoxyli, angelica sinensis, radix fici simplicissimae and cudrania cochinchinensis are purified and dried in a vacuum state to prepare Gongyanping dry extract powder; a problem that traditional Chinese medicine extract is easy to stick is solved, the quality of the Gongyanping dry extract powder is more stable and the Gongyanping dry extract powder is suitable for mass production; a vaginal drug matrix is added to the Gongyanping dry extract powder; the finally prepared Gongyanping vaginal suppository or Gongyanping vaginal gel is applied to preparations of drugs for treating pelvic inflammatory diseases. The Gongyanping vaginal drug delivery semisolid preparation can directly act upon affected parts by using a vaginal drug delivery mode and has the advantages of high target property, small irritation, fast working and high biological availability.

Description

technical field [0001] The invention relates to the technical field of medicine, and in particular to a semi-solid preparation of Gongyanping for vaginal administration, a preparation method and application thereof. Background technique [0002] Pelvic inflammatory disease, including endometritis, salpingo-oophoritis, pelvic peritonitis, pelvic connective tissue inflammation and pelvic abscess, is a frequently occurring disease in women. Acute pelvic inflammatory disease refers to the acute inflammation of the female internal genitalia and its surrounding connective tissue and pelvic peritoneum, which is limited to one part or several parts at the same time; chronic pelvic inflammatory disease refers to the inflammation of the female internal genitalia and its surrounding connective tissue and pelvic peritoneum. Chronic inflammation. In modern western countries, 1% of women aged 15 to 30 suffer from acute or chronic pelvic inflammatory disease, and the incidence rate of wom...

AI Technical Summary

Problems solved by technology

Now on the market, Gongyanping Capsules, Gongyanping Tablets, Gongyanping Dispersible Tablets, Gongyanping Dropping Pills, Gongyan Ping oral liquid, Gongyanping granules, etc. are all oral dosage forms, and there are defects such as that the drug effect is destroyed by the first-pass action of the liver, the drug effect is destroyed by gastrointestinal pH or enzymes, and is irritating to the gastric mucosa. Patients who are unwilling to swallow tablets, pills or capsules, patients with vomiting and other factors limit the wide application of the above oral dosage forms of Gongyanping in modern clinical practice