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Preparation method of styptic powder

A technology of hemostatic powder and mesoporous silicon, which is applied in the field of preparation of hemostatic powder, can solve the problems of restricting the application of thrombin and poor storage stability, and achieve the effects of convenient preparation and use, good stability, and improved hemostatic performance

Inactive Publication Date: 2017-06-09
QINGDAO SHUNXIN ELECTRONICS SCI & TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because thrombin is a protein-based hemostatic factor, its storage stability is poor, and it needs to be freeze-dried and stored at low temperature, which greatly restricts the application of thrombin in emergency dressings.

Method used

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0014] The specific implementation manner of the present invention will be described in detail below in conjunction with the technical solutions.

[0015] The preparation method of hemostatic powder of the present invention comprises the following steps:

[0016] (1) Preparation of mesoporous silicon dioxide particles: Mix 20ml of tetraethyl orthosilicate, 10ml of ethanol, 2ml of polyether polyol P123 with an average molecular weight of 5800, and 1ml of 2mol / L hydrochloric acid at 45°C for 5 hours. Calcined for 7 hours, ball milled for 3 hours, and sieved with 150 mesh to obtain mesoporous silicon dioxide particles;

[0017] (2) 4g chitosan is dissolved in the acetic acid aqueous solution of 1.2% in 200ml volume concentration, adds 7g polyethylene glycol 20000, obtains chitosan solution, is called A liquid; Dendritic polyetherimide is dissolved in In the phosphate buffer, configure a polyetherimide solution with a mass concentration of 1 mg / mL, called B solution; dissolve tan...

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PUM

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Abstract

A preparation method of hemostatic powder belongs to the technical field of external medicine. The preparation method of the present invention comprises the following steps: (1) preparation of mesoporous silica particles; (2) preparation of hemostatic dipping solution; (3) immersion to obtain hemostatic powder. The main components of the hemostatic powder prepared by the invention are chitosan, thrombin and tannic acid. The hydrogen bonding of thrombin and tannic acid greatly improves the storage stability of thrombin, and the mesoporous silica particles loaded with a large amount of thrombin and chitosan greatly improve the hemostatic performance, which makes up for the hemostatic effect of pure chitosan Limited flaws. The hemostatic powder of the invention can quickly stop bleeding, is especially suitable for pre-hospital emergency treatment of severely bleeding wounded, and has convenient preparation and use methods, and the prepared hemostatic powder has good stability.

Description

technical field [0001] The invention relates to a preparation method of hemostatic powder, which belongs to the technical field of external medicine. Background technique [0002] Chitosan (chitosan), also known as deacetylated chitin, is obtained by deacetylation of chitin (chitin), which exists widely in nature, and its chemical name is polyglucosamine (1-4)-2-amino-B-D glucose. . Since the Frenchman Rouget first obtained chitosan in 1859, the excellent properties of this natural polymer, such as biofunctionality, compatibility, blood compatibility, safety, and microbial degradation, have attracted widespread attention from all walks of life. Significant progress has been made in applied research in many fields such as medicine, food, chemical industry, cosmetics, water treatment, metal extraction and recovery, biochemical and biomedical engineering. [0003] Chitosan is easy to dissolve in a weak acid solvent, and it is particularly worth noting that the dissolved solut...

Claims

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Application Information

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IPC IPC(8): A61L24/10A61L24/08A61L24/04A61L24/02
CPCA61L24/08A61L24/0015A61L24/02A61L24/046A61L24/10A61L2300/254A61L2300/418A61L2400/04
Inventor 刘艾新
Owner QINGDAO SHUNXIN ELECTRONICS SCI & TECH CO LTD