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Mesalazine suppository

A technology for suppositories and suppositories of salazine, which is applied in suppository delivery, anti-inflammatory agents, non-central analgesics, etc. It can solve the problems of reduced absorption of mesalazine, discomfort when entering the body, poor therapeutic effect, etc., and achieve compliance Good, strong drug targeting, good therapeutic effect

Inactive Publication Date: 2017-06-13
KAMP PHARMA
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  • Summary
  • Abstract
  • Description
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AI Technical Summary

Problems solved by technology

[0005] Existing mesalamine suppositories are mostly angular in shape, which makes it uncomfortable to enter the body, and it starts to be released as soon as it enters the body. The targeting of the drug is checked, and the absorption of mesalamine is reduced, and the therapeutic effect is not good.

Method used

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  • Mesalazine suppository
  • Mesalazine suppository

Examples

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Embodiment 1

[0026] Mesalazine suppository preparation method (step implementation diagram sees figure 2 ):

[0027] 1) Add the molten suppository matrix from catheter A into the mold;

[0028] 2) Replace catheter A with catheter B and put it into the matrix in step 1), blow in low-temperature nitrogen for 30 seconds, stop the ventilation, shape the outer matrix, take out catheter B, and insert catheter A;

[0029] 3) Grind or sieve mesalamine, and melt it into the suppository base at 40-44°C;

[0030] 4) The material obtained in step 3) is added into the outer matrix obtained in step 1) through the catheter A, and the catheter A is gently pulled out to obtain the product.

[0031] The action principle and effect of the suppository: The melting point of the suppository as a whole does not exceed 37°C. After the suppository enters the terminal ileum and colon, the pH rises above 7.5, the coating layer dissolves rapidly, the core of the pill absorbs water and disintegrates, and the drug i...

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Abstract

The invention discloses a mesalamine suppository, which is characterized in that the shape of the mesalamine suppository is a smooth ellipsoid. In the double-layer suppository, the inner layer contains the main drug mesalamine, and the outer layer does not contain any substance other than the base. The smooth ellipsoid plug of the present invention is more comfortable to enter in the anus; the advantage of the double-layer plug is that the melting of the outer plug preserves the utilization rate of the main drug mesalazine.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a mesalazine suppository and a preparation method thereof. Background technique [0002] Mesalazine is clinically used to treat inflammatory bowel diseases such as ulcerative colitis and Crohn's disease. It has a significant anti-inflammatory effect on intestinal wall inflammation, acts on lipoxygenase and cyclooxygenase in the arachidonic acid metabolic pathway, inhibits the synthesis of inflammatory mediator leukotrienes (CTB4), thereby promoting the progression of inflammatory bowel disease outcome. The drug acts locally at the intestinal lesion site and loses its curative effect after absorption. If it is taken orally in a normal way, it is easily absorbed in the small intestine. After absorption, it will not only reduce the drug reaching the colon, but also cause side effects such as headache and nephrotoxicity. Therefore, mesalamine needs to be made...

Claims

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Application Information

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IPC IPC(8): A61K9/02A61K31/606A61P1/00A61P29/00
CPCA61K9/025A61K31/606A61K47/14A61K47/42A61K47/44
Inventor 吴健民何嫦贺莲
Owner KAMP PHARMA
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