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Anti-keratitis konjac glucomannan eye drops and preparation method thereof

A technology of konjac glucomannan and glucomannan eye is applied in the field of eye drops and preparation thereof, and achieves the effects of stable performance, good anti-keratitis performance and convenient material extraction.

Inactive Publication Date: 2017-06-13
FUJIAN AGRI & FORESTRY UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The purpose of the present invention is to provide a kind of anti-keratitis konjac glucomannan eye drops and its preparation method, to overcome the shortcomings of the existing drugs for the treatment of fungal keratitis

Method used

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  • Anti-keratitis konjac glucomannan eye drops and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1, a kind of preparation method of anti-keratitis konjac glucomannan eye drops, comprises the following steps:

[0024] (1) Preparation of paraffin wax emulsion: according to mass parts, take 78 parts of liquid paraffin, add 4 parts of glycerol, stir and place it in a water bath at 40°C, after the glycerol is dissolved, make a paraffin wax emulsion for later use;

[0025] (2) Preparation of sol: take 6 parts of konjac glucomannan, 2 parts of voriconazole, 1 part of ofloxacin, 1 part of doxycycline, add 300 parts of ultrapure water to prepare a sol;

[0026] (3) Preparation of sol emulsion: take 82 parts of the paraffin wax emulsion in step (1), add it to the sol in step (2), stir at 600 r / min, and sonicate for 40 min; then add 5 parts of epichlorohydrin, 500 r / min min stirring, and reacted in a 40 ℃ water bath for 10 h to prepare a sol emulsion;

[0027] (4) Preparation of konjac glucomannan-loaded microspheres: take the sol emulsion of step (3), centrifuge ...

Embodiment 2

[0029] Embodiment 2, a kind of preparation method of anti-keratitis konjac glucomannan eye drops, comprising the following steps:

[0030] (1) Preparation of paraffin wax emulsion: prepare 80 parts by mass of liquid paraffin, add 5 parts of glycerol, stir and place in a 42°C water bath, and prepare paraffin wax emulsion after glycerin is dissolved, for use;

[0031] (2) Preparation of sol: take 7 parts of konjac glucomannan, 3 parts of voriconazole, 2 parts of ofloxacin, 2 parts of doxycycline, add 300 parts of ultrapure water to prepare a sol;

[0032] (3) Preparation of sol emulsion: take 85 parts of the paraffin wax emulsion in step (1), add it to the sol in step (2), stir at 600 r / min, and sonicate for 40 min; then add 6 parts of epichlorohydrin, 500 r / min min stirring, and reacted in a 40 ℃ water bath for 10 h to prepare a sol emulsion;

[0033] (4) Preparation of konjac glucomannan-loaded microspheres: take the sol emulsion of step (3), centrifuge at 1000 r / min for 10 m...

Embodiment 3

[0035] Embodiment 3, a kind of preparation method of anti-keratitis konjac glucomannan eye drops, comprising the following steps:

[0036] (1) Preparation of paraffin wax emulsion: according to mass parts, take 79 parts of liquid paraffin, add 5 parts of glycerol, stir and place it in a 40°C water bath, after the glycerol is dissolved, make a paraffin wax emulsion, for use;

[0037] (2) Preparation of sol: take 8 parts of konjac glucomannan, 4 parts of voriconazole, 3 parts of ofloxacin, 3 parts of doxycycline, and add 300 parts of ultrapure water to prepare a sol;

[0038] (3) Preparation of sol emulsion: take 84 parts of the paraffin wax emulsion in step (1), add it to the sol in step (2), stir at 600r / min, and sonicate for 40min; then add 7 parts of epichlorohydrin, 500r / min min stirring, and reacted in a 40 ℃ water bath for 10 h to prepare a sol emulsion;

[0039] (4) Preparation of konjac glucomannan-loaded microspheres: take the sol emulsion of step (3), centrifuge at 1...

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Abstract

The invention relates to anti-keratitis konjac glucomannan eye drops and a preparation method thereof. The preparation method of the anti-keratitis konjac glucomannan eye drops comprises the following steps: preparing paraffin wax emulsion, preparing sol, preparing sol emulsion, preparing konjac glucomannan drug-carrying microspheres and preparing the anti-keratitis konjac glucomannan eye drops. According to the anti-keratitis konjac glucomannan eye drops, konjac glucomannan is used as a main raw material and a carrier; the gelling property, water-retaining property, water solubility and anti-keratitis property of the konjac glucomannan are utilized, and voriconazole, ofloxacin and doxycycline are added, so that the anti-keratitis effect is comprehensively expressed; and the anti-keratitis konjac glucomannan eye drops are used for treating fungal keratitis. The konjac glucomannan drug-carrying microspheres have stable performances, and have high bioavailability, good anti-keratitis performance, good water solubility and good anti-inflammatory performance. According to the anti-keratitis konjac glucomannan eye drops, the used materials are simple; and the anti-keratitis konjac glucomannan eye drops have the advantages of convenience for taking the materials, toxin and no harms, no secondary pollution and the like.

Description

technical field [0001] The invention relates to an eye drop and a preparation method thereof, in particular to an anti-keratitis konjac glucomannan eye drop and a preparation method thereof. Background technique [0002] Fungal keratitis is an infectious corneal disease caused by pathogenic fungi with a high blinding rate. So far, more than 70 kinds of fungi have been found to cause corneal infection. According to the different pathogenic roles of fungi in eye infections, they are divided into two categories: filamentous fungi and yeasts. With the widespread use of broad-spectrum anti-inflammatory drugs, glucocorticoids and antiviral drugs in clinical practice, the incidence of fungal keratitis in China has gradually increased, and the disease has become more serious. Voriconazole is an imidazole antifungal drug, which can change the permeability of fungal outer membrane by inhibiting the activity of bacteriochrome synthase, and exert an anti-keratitis effect in an all-rou...

Claims

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Application Information

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IPC IPC(8): A61K31/65A61K31/5383A61K31/506A61K47/36A61K9/08A61P27/02A61P31/10
CPCA61K31/65A61K9/0048A61K9/08A61K31/506A61K31/5383A61K47/36A61K2300/00
Inventor 庞杰王林吴佳煜穆若郡王维海倪永升龚静妮洪馨刘子奇
Owner FUJIAN AGRI & FORESTRY UNIV
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