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Traditional Chinese medicine composition by using syzygium jambos leaves as main raw material and application thereof

The technology of a main raw material and composition, applied in the field of natural medicinal chemistry, can solve the problems of unreported effects of rose fruit leaves on liver damage, and achieve excellent liver damage effects, strong liver damage effects, liver protection and liver protection effects strong effect

Inactive Publication Date: 2017-06-13
FOSHAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] There is no report in the prior art that the combination of rose apple leaves, tangerine peel and magma fruit has the effect of treating liver damage

Method used

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  • Traditional Chinese medicine composition by using syzygium jambos leaves as main raw material and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The preparation of embodiment 1 Chinese medicine composition

[0024] Traditional Chinese medicine raw materials: 100 parts of rose apple leaves; 60 parts of tangerine peel; 30 parts of symphylla fruit;

[0025] Preparation:

[0026] (1) rose apple leaves, tangerine peel and symphylla are mixed according to the above ratio, then add 8 times of ethanol (volume fraction of ethanol is 60%) of rose apple leaves, tangerine peel and symphylla gross weight, and carry out heating and reflux extraction , the extraction time is 2h, and the number of extractions is 3 times; the extracts are combined each time, and the concentrated extracts become thick paste to obtain ethanol extracts;

[0027] (2) The ethanol extract prepared by step (1) is dissolved in water into a suspension, then extracted 3 times with petroleum ether equal to the volume of the suspension, and extracted 3 times with ethyl acetate equal to the volume of the suspension Once, the ethyl acetate extracts were com...

Embodiment 2

[0028] The preparation of embodiment 2 Chinese medicine composition

[0029] Traditional Chinese medicine raw materials: 80 parts of rose apple leaves; 50 parts of tangerine peel; 40 parts of symphylla fruit;

[0030] Preparation:

[0031] (1) rose apple leaves, tangerine peel and symphylla are mixed according to the above ratio, then add 8 times of ethanol (volume fraction of ethanol is 60%) of rose apple leaves, tangerine peel and symphylla gross weight, and carry out heating and reflux extraction , the extraction time is 2h, and the number of extractions is 3 times; the extracts are combined each time, and the concentrated extracts become thick paste to obtain ethanol extracts;

[0032] (2) The ethanol extract prepared by step (1) is dissolved in water into a suspension, then extracted 3 times with petroleum ether equal to the volume of the suspension, and extracted 3 times with ethyl acetate equal to the volume of the suspension Once, the ethyl acetate extracts were comb...

Embodiment 3

[0033] The preparation of embodiment 3 Chinese medicine composition

[0034] Traditional Chinese medicine raw materials: 120 parts of rose apple leaves; 70 parts of tangerine peel; 20 parts of symphylla fruit;

[0035] Preparation:

[0036] (1) rose apple leaves, tangerine peel and symphylla are mixed according to the above ratio, then add 8 times of ethanol (volume fraction of ethanol is 60%) of rose apple leaves, tangerine peel and symphylla gross weight, and carry out heating and reflux extraction , the extraction time is 2h, and the number of extractions is 3 times; the extracts are combined each time, and the concentrated extracts become thick paste to obtain ethanol extracts;

[0037] (2) The ethanol extract prepared by step (1) is dissolved in water into a suspension, then extracted 3 times with petroleum ether equal to the volume of the suspension, and extracted 3 times with ethyl acetate equal to the volume of the suspension Once, the ethyl acetate extracts were com...

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Abstract

The invention relates to the technical field of natural medicinal chemistry, and particularly discloses a traditional Chinese medicine composition by using syzygium jambos leaves as a main raw material and application thereof. The composition is prepared from traditional Chinese medicinal raw materials including syzygium jambos leaves, pericarpium citri reticulatae and common camptotheca fruits by the following steps: (1) mixing the syzygium jambos leaves, pericarpium citri reticulatae and common camptotheca fruits, extracting with ethanol, and concentrating the extract to obtain ethanol extract; and (2) dissolving the ethanol extract prepared in the step (1) with water, sequentially extracting with organic solvent A and organic solvent B, concentrating and drying the part extracted from the organic solvent B to obtain the traditional Chinese medicine composition. The traditional Chinese medicine composition has a liver protecting effect and has a effect for treating liver injury stronger than that of positive contrast medicinal liquid silymarin.

Description

technical field [0001] The invention relates to the technical field of natural medicine chemistry, in particular to a traditional Chinese medicine composition with rose apple leaves as the main raw material and its application. Background technique [0002] The liver is the largest solid organ in the abdominal cavity and is responsible for important physiological functions of the human body. Liver injury disease is a common disease. In liver injury diseases, many of them are liver injuries caused by chemical hepatotoxic substances, which are called chemical liver injuries. These chemicals include alcohol, toxic chemicals in the environment, and certain drugs. As an important detoxification organ of the human body - the liver has dual blood supply from the hepatic artery and the hepatic vein. Chemicals can enter the liver through the portal vein of the gastrointestinal tract or the systemic circulation for transformation, so the liver is vulnerable to toxic substances in c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/752A61P1/16
CPCA61K36/185A61K36/61A61K36/752A61K2236/333A61K2300/00
Inventor 李国强陈能花谭卓杰王国才李药兰
Owner FOSHAN UNIVERSITY
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