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Pharmaceutical composition for treating migraine

A composition and technology for migraine, applied in the directions of drug combination, pharmaceutical formula, pill delivery, etc., can solve problems such as addiction, mental and physical dependence, and achieve the effects of improving symptoms, being convenient to carry, and having good preventive and therapeutic effects.

Inactive Publication Date: 2017-06-16
许勇男
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0018] Repeated use of opioid painkillers during the treatment of migraine can easily lead to mental and physical dependence and even addiction

Method used

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  • Pharmaceutical composition for treating migraine
  • Pharmaceutical composition for treating migraine
  • Pharmaceutical composition for treating migraine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] 1. Preparation of Armillaria polysaccharide

[0044] 1.1 Preparation of Armillaria fruiting body polysaccharide: Weigh Armillaria fruiting body according to 20 times of the above mass ratio, wash and dry at 60°C, crush into a coarse powder of about 1 mm, the ratio of solid to liquid is 1:20, and the temperature is 100°C. Add water and reflux to extract twice, the first time is 3 hours, and the second time is 2 hours; combine the extracts and concentrate in vacuum to form a clear paste with a relative density of 1.10-1.20 (room temperature); use 3-4 times the amount of 95% ( mass fraction) ethanol precipitation for 24 hours; take the precipitate, wash it with absolute ethanol 3 times, then dissolve it with 4 times the amount (mass fraction) of ≥80°C hot water, let it cool to 40°C~50°C, add 1%~ 3% (mass ratio) papain, keep warm for 4 to 5 hours; add chloroform / n-butanol mixed solution according to the ratio of polysaccharide aqueous solution: chloroform: n-butanol 25:4:1...

Embodiment 2

[0047] Preparation of low-molecular-weight fucoidan sulfate: take fucoidan sulfate extracted from kelp or fucus, dissolve it in water at a ratio of 1.5% to 3.0%, and sterilize at 100°C for 20-30min; cool the aqueous solution of fucoidan sulfate to 60°C- At 70°C, add arabinofuranosidase at a ratio of 1% to 3%, the optimum pH is ≤7, the optimum reaction temperature is 60°C, and the reaction time is 4 to 5 hours to degrade fucoidan sulfate; vacuum concentration, concentrated solution Add ethanol to 75%, collect the precipitate, dry and pulverize to obtain low molecular weight fucoidan sulfate ester, and its molecular weight (MW) should be 60,000-130,000.

Embodiment 3

[0049] Preparation of the active composition granules of the present invention: Weigh 1000g of Armillaria polysaccharide, 100g of low molecular weight fucoidan sulfate, 250g of γ-aminobutyric acid, and 1650g of maltodextrin, mix them evenly, and use a 14-16 mesh nylon sieve Made into wet granules, dried at 50°C to 60°C until the moisture content is ≤5.0% (mass ratio), packed into bags, 3g per bag, made into 1000 bags.

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PUM

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Abstract

The invention discloses the application of an active composition in medicines for treating migraine and discloses a pharmaceutical composition for treating migraine. The composition is composed of active ingredients and an auxiliary material. The active ingredients comprise armillaria mellea polysaccharide, low molecular weight sulfated fucans and gamma-aminobutyric acid. Maltodextrin is adopted as the auxiliary material. The active composition disclosed by the invention is obvious in effect of treating and preventing migraine and is suitable for being taken by the crowd suffering from migraine for a long time. The active ingredients in the invention are foods or novel food materials, and the composition has the advantages of being safe to eat, rapid in absorption, capable of being taken for a long time, small in size, convenient to carry and the like and is easily accepted by patients.

Description

technical field [0001] The invention relates to the application of an active composition in medicine for treating migraine, which belongs to the technical field of medicine, that is, a medicine composition for treating migraine. Background technique [0002] Migraine (migraine) is the most common primary headache type of chronic neurovascular disease. Migraine is a clinical common and frequently-occurring disease characterized by severe, left or right, recurrent, throbbing pain, generally lasting 4 to 72 hours. It can be accompanied by nausea, vomiting and other symptoms. Typical migraine patients have prodromal symptoms and predisposing factors, such as mood swings, lack of sleep, and alcohol consumption. Light, sound, or movement can make the headache worse, and rest in a quiet environment can relieve the headache. According to epidemiological investigation and analysis, the incidence of migraine is higher in western countries. In the United States, the annual prevalenc...

Claims

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Application Information

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IPC IPC(8): A61K31/737A61K31/715A61K31/197A61K9/16A61K9/20A61P25/06
CPCA61K31/715A61K9/1652A61K9/2059A61K31/197A61K31/737A61K2300/00
Inventor 许勇男
Owner 许勇男