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A multifunctional amorphous iron nanometer material, a preparing method thereof and applications of the material

A nanomaterial, iron nanotechnology, applied in the field of nanomaterials and biomedical materials, can solve problems such as harm and neurological dysfunction, and achieve the effects of avoiding side effects, improving specificity, and efficient cancer cell killing ability

Active Publication Date: 2017-06-23
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Claims
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Problems solved by technology

The T1-weighted contrast agent currently used clinically is Magnevist (Gd-DTPA), but the US Food and Drug Administration (FDA) has recently warned that the use of gadolinium-based contrast agents can cause some kidney and liver diseases, and manganese-based contrast agents are Can lead to neurological dysfunction, it can be seen that these existing T1-weighted contrast agents are harmful

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  • A multifunctional amorphous iron nanometer material, a preparing method thereof and applications of the material
  • A multifunctional amorphous iron nanometer material, a preparing method thereof and applications of the material
  • A multifunctional amorphous iron nanometer material, a preparing method thereof and applications of the material

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preparation example Construction

[0072] Ferric sulfate was selected as the iron source, the foaming agent used was Pluronic F127, and the coated organic matter was polyvinylpyrrolidone, wherein the molar ratio of Pluronic F127 to polyvinylpyrrolidone was 10:1, and the precursor solution was obtained by fully stirring , wherein the molar concentration of ferric sulfate solution is 0.02mol / ml, and the molar ratio of foaming agent to ferric sulfate is 1:1. The reducing agent used is sodium hypophosphite, and the molar ratio of reducing agent to iron sulfate is 5:1. The described boiling preparation method synthesizes amorphous iron nanoparticles, and its process includes the following operations:

[0073] a) dissolving ferric sulfate and foaming agent weighed in proportion in water, fully stirring at room temperature, making it evenly mixed to form a precursor solution;

[0074] b) Under the protection of argon, heat to 90°C, keep stirring for 3 hours, and remove dissolved oxygen in the water;

[0075] c) Pass...

Embodiment 1

[0085] Weigh 0.6mol of ferric sulfate, 0.55mol of Pluronic F127 and 0.055mol of polyvinylpyrrolidone, put them in a 100ml three-neck flask, and dissolve them with 30ml of deionized water; under the protection of argon, raise the temperature of the system to 90°C for 3h, fully Remove dissolved oxygen in water; put the argon gas tube into the precursor solution, and bubble for 1 hour; after the bubble system is stable, weigh 3 mol of sodium hypophosphite and dissolve it in 10ml of deionized water, and slowly add it into the reaction system at a rate of 10ml / hour through a syringe pump , and kept warm for 2h under an argon atmosphere; after the reaction was completed, the system temperature dropped to room temperature, and several times of centrifugation and cleaning were performed with deoxygenated water to prepare amorphous iron nanoglasses with polyvinylpyrrolidone surface-modified, which were dispersed in deoxygenated In water, sealed and stored for later use.

[0086] figur...

Embodiment 2

[0165] Weigh 0.5mol of ferric chloride, 1mol of Pluronic F127 and 0.05mol of polyvinylpyrrolidone, put them in a 100ml three-necked flask, and dissolve them with 30ml of deionized water; under the protection of argon, heat the system to 90°C for 3h, fully Remove dissolved oxygen in water; put the argon gas tube into the precursor solution, and bubble for 1 hour; after the bubble system is stable, weigh 3 mol of sodium borohydride and dissolve it in 10 ml of deionized water, and slowly add it into the reaction system at a rate of 10 ml / hour through a syringe pump , and kept warm for 2h under an argon atmosphere; after the reaction was completed, when the temperature of the system dropped to room temperature, several times of centrifugation and cleaning were performed with deoxygenated water to prepare amorphous iron nanoparticles with polyvinylpyrrolidone surface-modified, which were dispersed in deoxygenated In water, sealed and stored for later use.

[0166] Figure 26 The t...

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Abstract

The invention relates to a multifunctional amorphous iron nanometer material, a preparing method thereof and applications of the material. The material includes an amorphous iron nanometer core and an organic covering layer on the surface of the amorphous iron nanometer core. The diameter of the amorphous iron nanometer core in the material is 10-300 nm. The nanometer material is ferromagnetic amorphous iron nanometer particles having unique properties, can be rapidly dissociated under weakly acidic conditions, has a magnetic targeting function, a T1 nuclear magnetic imaging mediation function and a function of activating tumor endogenous chemical kinetic treatment, and can be adopted as a nanometer diagnosis and treatment agent to achieve high-specificity chemical kinetic treatment on tumor.

Description

technical field [0001] The invention relates to the technical field of nanomaterials and the field of biomedical materials, in particular to an amorphous iron nanomaterial with magnetic targeting and T1 nuclear magnetic imaging mediation functions, which can be used for tumor chemokinetic therapy and its preparation method and application. Background technique [0002] Malignant tumor has become the first killer of human life and health, and its specific and efficient treatment has attracted more and more attention. Due to its high specificity, cancer treatment strategies based on the tumor microenvironment have gradually been favored by researchers in recent years. The tumor microenvironment mainly includes: (1) slightly acidic due to active anaerobic glycolysis producing a large amount of acidic substances; (2) inhibition of catalase expression leading to a large accumulation of hydrogen peroxide. A widely studied strategy is to use the tumor's slightly acidic or overexpr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/12A61K49/18A61P35/00A61K47/02A61K47/32A61K47/10A61K47/18
CPCA61K47/02A61K47/10A61K47/32A61K47/34A61K49/12A61K49/126A61K49/1854A61K49/1857A61K49/186
Inventor 张辰魏晨阳步文博施剑林
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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