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Traditional Chinese medicine compound composition for delaying progress of chronic kidney diseases and clinical application of traditional Chinese medicine compound composition

A kidney disease, chronic technology, applied in the field of medicine, can solve the problems of increased patient expenditure, ineffective curative effect, waste of drug sources, etc., achieve the effect of reducing proteinuria and hematuria, obvious curative effect, and easy administration

Inactive Publication Date: 2017-06-27
THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0010] Chinese patent CN104027433 B discloses a traditional Chinese medicine composition and its preparation method and clinical preparation. The composition consists of astragalus, angelica, Achyranthes bidentata, Chuanxiong, Atractylodes macrocephala, heterophylla, licorice, cicada slough, hedyotis diffusa, Gorgon fruit, and golden cherry Composition, this traditional Chinese medicine composition is mainly used to treat symptoms such as proteinuria and hematuria caused by the initial stage of kidney disease, but it has no obvious curative effect on the increase of serum creatinine and blood urea nitrogen caused by the continuous aggravation of chronic kidney disease.
The above-mentioned composition has the characteristics of reducing proteinuria or hematuria, etc., but the prescription of the above-mentioned traditional Chinese medicine composition uses famous and precious animal medicines such as pangolin and scorpion. The waste of resources, the increase of patient expenditure, and the drug effect are not high; some prescriptions directly use nephrotoxic drugs containing high aristolochic acid; The way and method used are not in line with the law of dialectical medication of traditional Chinese medicine, and its therapeutic effect is difficult to be recognized. For the key issues in the treatment of chronic kidney disease, the protective effect of renal function lacks theoretical basis and direct curative effect

Method used

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  • Traditional Chinese medicine compound composition for delaying progress of chronic kidney diseases and clinical application of traditional Chinese medicine compound composition
  • Traditional Chinese medicine compound composition for delaying progress of chronic kidney diseases and clinical application of traditional Chinese medicine compound composition
  • Traditional Chinese medicine compound composition for delaying progress of chronic kidney diseases and clinical application of traditional Chinese medicine compound composition

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0078] The preparation of embodiment 1 Chinese medicine composition

[0079] Weigh raw materials according to the following proportions:

[0080] Astragalus 30g, Angelica 20g, Achyranthes bidentata 10g, Chuanxiong 20g, rhubarb 5g, Liuyuexue 10g, licorice 9g, Hedyotis diffusa 15g, Centella asiatica 30g, Zhuru 30g.

[0081] Preparation:

[0082] (1) Angelica and Chuanxiong were steam-distilled for 3 hours to extract volatile oil, and the distilled water was collected, and the dregs were decocted and extracted 3 times with 5 times the amount of water, each time for 2 hours, filtered, and the filtrate was combined with the above-mentioned distilled water, under normal pressure Or concentrated under reduced pressure to form a clear paste, the relative density of the clear paste measured at 75°C is 1.2;

[0083] (2) Add astragalus, Achyranthes bidentata, rhubarb, Liuyuexue, raw licorice, Hedyotis diffusa, Centella asiatica, Zhuru to the dregs extracted in step (1), and add 10 time...

Embodiment 2

[0086] The preparation of embodiment 2 Chinese medicine composition

[0087] Weigh raw materials according to the following proportions:

[0088] Astragalus 60g, Angelica 10g, Achyranthes bidentata 5g, Chuanxiong 10g, rhubarb 15g, Liuyuexue 1g, licorice 1g, Hedyotis diffusa 60g, Centella asiatica 60g, Zhuru 300g.

[0089] Preparation:

[0090] (1) Steam distill Angelica and Rhizoma Chuanxiong for 4 hours to extract volatile oil, collect the distilled water, add 8 times the amount of water to decoct the dregs, extract once, 1 hour each time, filter, and combine the filtrate with the above-mentioned distilled water, normal pressure Or concentrated under reduced pressure to form a clear paste, the relative density of the clear paste measured at 70°C is 1.15;

[0091] (2) Add astragalus, achyranthes bidentata, rhubarb, liuyuexue, raw licorice, hedyotis diffusa, centella asiatica, bamboo rutabaga to the dregs extracted in step (1), add 6 times the volume of decoction Boil and de...

Embodiment 3

[0094] The preparation of embodiment 3 Chinese medicine composition

[0095] Weigh raw materials according to the following proportions:

[0096] Astragalus 50g, Angelica 15g, Achyranthes bidentata 1g, Chuanxiong 1g, rhubarb 10g, Liuyuexue 15g, licorice 6g, Hedyotis diffusa 30g, Centella asiatica 50g, Zhuru 60g.

[0097] Preparation:

[0098] (1) Steam distill Angelica and Rhizoma Chuanxiong for 2 hours to extract volatile oil, collect the distilled water liquid, add 7 times the amount of water to decoct and extract the medicinal residue once, 1 hour each time, filter, and combine the filtrate with the aforementioned distilled water liquid, normal pressure Or concentrate under reduced pressure to form a clear paste, and the relative density of the clear paste is 1.1 when measured at 70°C;

[0099] (2) Add astragalus, achyranthes bidentata, rhubarb, liuyuexue, raw licorice, hedyotis diffusa, centella asiatica, bamboo rutabaga to the dregs extracted in step (1), add 7 times th...

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Abstract

The invention discloses a traditional Chinese medicine compound composition for delaying progress of chronic kidney diseases and clinical application of the traditional Chinese medicine compound composition. The traditional Chinese medicine compound composition which is a pure traditional Chinese medicine preparation comprises a plurality of traditional Chinese medicines including radix astragali, radix angelicae sinensis, rhizoma chuanxiong, radix achyranthis bidentatae, radix et rhizoma rhei preparata, serissa japonica, radix glycyrrhizae, hedyotis diffusa, herba centellae and caulis bambusae in taenia. The traditional Chinese medicine compound composition and the clinical application have the advantages that as shown by completed pharmacodynamical research and clinical research, the kidney fibrotic lesion degrees of experimental animals can be obviously improved by the preparation, the creatinine levels can be lowered, and kidney functions can be protected; the kidney pathological lesion degrees related to the chronic kidney diseases can be improved, and mechanisms related to curative effects are verified from the angle of molecular biology; as shown by clinical research, proteinuria and hematuria conditions related to the chronic kidney diseases can be reduced by the traditional Chinese medicine preparation, and deterioration of creatinine clearance rates (computed by the aid of Cockcraft-Gault formulas) of patients suffering from the chronic kidney diseases can be obviously controlled; the total treatment effective rate can reach 98% at least, expenditure required for treating the diseases can be reduced for the patients, the stable curative effects can be realized, and the traditional Chinese medicine compound composition is free of obvious toxic and side effects.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a traditional Chinese medicine compound composition for delaying the progress of chronic kidney disease and its clinical application. Background technique [0002] Chronic kidney disease is based on the clinical practice guidelines (K / DOQI) developed by the American Kidney Foundation (NKF), and the International Society of Nephrology Improving the Overall Outcome of Kidney Disease Working Group (KDIGO) clearly proposed the definition of chronic kidney disease: ( 1) Renal damage (abnormal kidney structure or function) for ≥ 3 months, with or without decreased glomerular filtration rate (GFR), abnormal renal pathological examination or renal damage (abnormal blood and urine components or imaging examinations) ); (2) eGFR<60ml·min -1 ·(1.73m 2 ) -1 ≥3 months, with or without evidence of renal impairment. [0003] Chronic kidney disease is the general clinical ter...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61P13/12
CPCA61K36/21A61K36/23A61K36/232A61K36/236A61K36/481A61K36/484A61K36/708A61K36/74A61K36/748A61K36/899A61K2236/331A61K2236/39A61K2236/51A61K2300/00
Inventor 魏明刚
Owner THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIV
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