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A kind of platinum copper nanocrystal used as tumor photothermal ablation diagnosis and treatment agent and preparation method

A photothermal ablation, platinum-copper technology, applied in anti-tumor drugs, medical preparations containing active ingredients, pharmaceutical formulations, etc., to achieve the effects of good structural stability, good crystal shape and low price

Active Publication Date: 2020-12-29
HENAN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the development of platinum-copper bimetallic nanocrystals into a near-infrared photothermal conversion agent and its application in photothermal ablation therapy of tumors has not been reported.

Method used

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  • A kind of platinum copper nanocrystal used as tumor photothermal ablation diagnosis and treatment agent and preparation method
  • A kind of platinum copper nanocrystal used as tumor photothermal ablation diagnosis and treatment agent and preparation method
  • A kind of platinum copper nanocrystal used as tumor photothermal ablation diagnosis and treatment agent and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Example 1 Preparation of cubic platinum-copper bimetallic nanocrystals

[0039] Dissolve a certain amount of precursor platinum salt and copper salt in the oleylamine solution containing cationic surfactant, so that the concentration of the precursor platinum salt is: 0.05mol / L; the concentration of the precursor copper salt is: 0.1mol / L; The concentration of the surfactant is: 0.02mol / L; the dosage of oleylamine is: 10mL. The above mixed solution was reacted at 170° C. for 24 hours with a stirring speed of 400 rpm / min, and then cooled to room temperature under stirring to obtain a platinum-copper bimetallic nanocrystal solution.

[0040] Acetone and the platinum-copper bimetallic nanocrystal solution prepared above were mixed at a volume ratio of 1:1, and then centrifuged at a speed of 9000 rpm / min for 10 min to obtain a precipitate. Mix the acetone and the obtained precipitate in the same ratio as above, that is, the volume ratio of 1:1, centrifuge to take the precip...

Embodiment 2

[0042] Example 2 Preparation of spherical platinum-copper bimetallic nanocrystals

[0043] Dissolve a certain amount of precursor platinum salt and copper salt in the oleylamine solution containing cationic surfactant, so that the concentration of the precursor platinum salt is: 0.05mol / L; the concentration of the precursor copper salt is: 0.1mol / L; The concentration of the surfactant is: 0.02mol / L; the dosage of oleylamine is: 0 mL. The above mixed solution was reacted at 170° C. for 8 hours with a stirring speed of 400 rpm / min, and then cooled to room temperature under stirring to obtain a platinum-copper bimetallic nanocrystal solution.

[0044] Acetone was mixed with the platinum-copper bimetallic nanocrystal solution prepared above at a volume ratio of 1:1, and then centrifuged at a speed of 12000 rpm / min for 10 min to obtain a precipitate. The obtained precipitate was repeatedly washed 6 times in the same manner as above, and the finally obtained precipitate was placed ...

Embodiment 3

[0046] Example 3 Preparation of snowflake-like platinum-copper bimetallic nanocrystals

[0047] Dissolve a certain amount of precursor platinum salt and copper salt in the oleylamine solution containing cationic surfactant, so that the concentration of the precursor platinum salt is: 0.05mol / L; the concentration of the precursor copper salt is: 0.2mol / L; The concentration of the surfactant is: 0.04mol / L; the dosage of oleylamine is 25mL. The above mixed solution was reacted at 170° C. for 48 hours with a stirring speed of 400 rpm / min, and then cooled to room temperature under stirring to obtain a platinum-copper bimetallic nanocrystal solution.

[0048] Acetone was mixed with the snowflake-shaped platinum-copper nanocrystal solution prepared above at a volume ratio of 1:1, and then centrifuged at a speed of 10000 rpm / min for 10 min to obtain a precipitate. The obtained precipitate was repeatedly washed 6 times in the same manner as above, and the finally obtained precipitate ...

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Abstract

The invention relates to platinum-copper nanocrystals as a tumor photothermal ablation diagnosis and treatment agent and a preparation method thereof, and belongs to the technical field of nano biomaterials. The platinum-copper bimetallic nanocrystals have the particle size in a range of 5-200 nm and have the basic structure of PtCun, wherein n is in the range of 0-5; the morphology has one or more of cube, sphere, snowflake shape, and lamellar shape. The platinum-copper nanocrystals can be applied to near infrared light mediated tumor photothermal ablation, and are applicable to the near infrared light wavelength range of 700-1100 nm. The platinum-copper nanocrystals are prepared by a pyrolysis method, and in a high-boiling-point oil phase medium, the snowflake-shaped platinum-copper bimetallic nanocrystals are prepared by metal precursor thermal reduction decomposition. The nanocrystals have the advantages of low cost, simple preparation, high purity, good crystal shape, controllable particle size and regular shape, are used as a near infrared photothermal conversion agent to be applied to tumor photothermal ablation, have obvious effect, and provide a research direction for tumor therapy.

Description

technical field [0001] The invention belongs to the technical field of nano-biological materials, and in particular relates to a platinum-copper nanocrystal used as a photothermal ablation diagnosis and treatment agent for tumors and a preparation method thereof. Background technique [0002] With the development of nanotechnology, noble metal nanomaterials have outstanding catalytic, electromagnetic and optical properties due to the effective superposition of their inherent surface effects, quantum size effects and interface effects, making them the richest materials in the field of nanotechnology. It is a dynamic sub-discipline and plays an important role in the development of modern industry, national defense and high technology. [0003] In recent years, platinum-based nanomaterials have been widely used in many fields due to their excellent photothermal conversion, hydrogenation catalysis and electrical sensing properties. However, as a rare precious metal, its limited...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61P35/00
CPCA61K41/0052
Inventor 李景华胡志刚景爱华麻开旺朱俊杰李星星田雯王明慧
Owner HENAN UNIV OF SCI & TECH
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