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Application of Aidi preparation in preparing medicines for treating malignant pleural mesothelioma

A preparation and malignant technology, applied in the application field of Aidi preparations in the preparation of drugs for the treatment of malignant trophoblastic tumors, can solve the problems of poor prognosis and poor quality of life, large toxic and side effects, etc.

Active Publication Date: 2017-07-07
GUIZHOU YIBAI PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The key to determining the curative effect is the choice of chemotherapy drugs, but the current chemotherapy drugs often have the problems of high toxicity and side effects, and poor prognosis and quality of life

Method used

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  • Application of Aidi preparation in preparing medicines for treating malignant pleural mesothelioma
  • Application of Aidi preparation in preparing medicines for treating malignant pleural mesothelioma
  • Application of Aidi preparation in preparing medicines for treating malignant pleural mesothelioma

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0076] Embodiment 1: the preparation of Aidi injection (low component)

[0077] Raw materials: Mylabris 4g, Ginseng 200g, Astragalus 450g, Acanthopanax 900g

[0078] Preparation method: take the herbaceous herbaceous material, pulverize it, heat and reflux with 400ml 100% ethanol to extract 5 times, the extraction time is respectively: 2h, 1h, 0.5h, 0.5h, 0.5h, filter, the dregs of the medicine are set aside, and the extract is extracted with 4% Adjust the sodium hydroxide solution to pH 8-9, recover ethanol under reduced pressure, filter, add water to dilute to 1000ml, adjust to pH 6-7 with 12% hydrochloric acid solution, let stand, refrigerate, and centrifugally filter, and the supernatant is washed with 4% hydrogen Adjust the sodium oxide solution to pH 8-9, and set aside; take ginseng slices, heat and reflux with 480ml 60% ethanol to extract for 3 hours, filter, and use the dregs for standby, extract the ethanol under reduced pressure, add water to the concentrated solutio...

Embodiment 2

[0079] Embodiment 2: the preparation of Aidi injection

[0080]Raw materials: Mylabris 5g, Ginseng 250g, Astragalus 500g, Acanthopanax 1000g

[0081] Preparation method: take the herbaceous herbaceous material, pulverize it, heat and reflux with 400ml 100% ethanol to extract 5 times, the extraction time is respectively: 2h, 1h, 0.5h, 0.5h, 0.5h, filter, the dregs of the medicine are set aside, and the extract is extracted with 4% Adjust the sodium hydroxide solution to pH 8-9, recover ethanol under reduced pressure, filter, add water to dilute to 1000ml, adjust to pH 6-7 with 12% hydrochloric acid solution, let stand, refrigerate, and centrifugally filter, and the supernatant is washed with 4% hydrogen Adjust the sodium oxide solution to pH 8-9, and set aside; take ginseng slices, heat and reflux with 480ml 60% ethanol to extract for 3 hours, filter, and use the dregs for standby, extract the ethanol under reduced pressure, add water to the concentrated solution to a volume of...

Embodiment 3

[0082] Embodiment 3: the preparation of Aidi injection

[0083] Raw materials: Mylabris 10g, Ginseng 300g, Astragalus 750g, Acanthopanax 1250g

[0084] Preparation method: take the herbaceous herbaceous material, pulverize it, heat and reflux with 400ml 100% ethanol to extract 5 times, the extraction time is respectively: 2h, 1h, 0.5h, 0.5h, 0.5h, filter, the dregs of the medicine are set aside, and the extract is extracted with 4% Adjust the sodium hydroxide solution to pH 8-9, recover ethanol under reduced pressure, filter, add water to dilute to 1000ml, adjust to pH 6-7 with 12% hydrochloric acid solution, let stand, refrigerate, and centrifugally filter, and the supernatant is washed with 4% hydrogen Adjust the sodium oxide solution to pH 8-9, and set aside; take ginseng slices, heat and reflux with 480ml 60% ethanol to extract for 3 hours, filter, and use the dregs for standby, extract the ethanol under reduced pressure, add water to the concentrated solution to a volume ...

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Abstract

The invention discloses an application of an Aidi preparation in preparing medicines for treating malignant pleural mesothelioma. The Aidi preparation consists of four medicines, namely Chinese blister beetles, ginseng, radix astragali and radix acanthopanacis semticosi. The Aidi preparation provided by the invention is relatively strong in effect on treating the malignant pleural mesothelioma; and the medicine (the Aidi preparation) is obvious in curative effect, low in side effects and safer in clinical administration; therefore, a novel therapeutic approach is provided for the treatment of the malignant pleural mesothelioma and clinical application of the Aidi preparation is widened.

Description

technical field [0001] The invention relates to a new application of an Aidi preparation, in particular to the application of an Aidi preparation in the preparation of medicines for treating malignant trophoblastic tumors. Background technique [0002] Malignant trophoblastic tumor is the malignant transformation of embryonic trophoblastic cells. Such tumors include invasive mole, choriocarcinoma and placental site trophoblastic tumor, and choriocarcinoma includes gestational choriocarcinoma and non-gestational choriocarcinoma. Sexual choriocarcinoma is rare, but can occur in retroperitoneal mediastinum, ovary, lung, esophagus, stomach, liver, pelvic cavity, etc. The etiology of trophoblasts is unclear, and may be related to malnutrition (especially lack of high-quality animal protein diet), viral infection, ovarian dysfunction and egg abnormalities, chromosomal abnormalities, immune function abnormalities, race, geography, climate and environmental influences. Malignant tr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/481A61P35/00A61K35/64
CPCA61K9/0019A61K9/08A61K36/254A61K36/258A61K36/481A61K2300/00
Inventor 窦啟玲隋东虎张圣贵
Owner GUIZHOU YIBAI PHARMA CO LTD
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