Application of thick-wall fungus probiotics to treatment and prevention of obesity and related diseases

A technology of probiotics and wall fungi, applied in the field of microbiology, can solve problems such as calculation errors, expensive, local or systemic drug allergy

Active Publication Date: 2017-07-25
SHENZHEN HUADA GENE INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For patients, the use of exogenous insulin is an expensive and painful method, and it also brings many complications to the patient
Insulin response (hypoglycemia) due to miscalculation of insulin doses, for example, due to missing meals or erratic exercise
In addition, local or systemic allergy or immune resistance to the drug may occur with the use of the drug
[0007] At present, there is no effective method and medicine for the treatment and prevention of obesity and its related diseases with little side effects

Method used

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  • Application of thick-wall fungus probiotics to treatment and prevention of obesity and related diseases
  • Application of thick-wall fungus probiotics to treatment and prevention of obesity and related diseases
  • Application of thick-wall fungus probiotics to treatment and prevention of obesity and related diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0117] Embodiment 1 Food composition containing Firmicutes probiotics (such as inert eubacterium, Haldemannia fibrils or a combination thereof)

[0118] The ratio of raw materials is shown in Table 1.

[0119] Table 1 food composition formula

[0120] raw material Mass percentage (%) Bacterial components 0.5 milk 90.0 white sugar 9.5

[0121]The bacterial components in formulas 1-6 are single bacterial components, which respectively contain Eubacterium siraeum DSM15702, Eubacterium siraeum 70 / 3, Eubacterium siraeum V10Sc8a, Holdemania filiformis DSM 12042, Holdemania filiformis VPI J1-37, Holdemania filiformis VPI S4B-1.

[0122] The bacterial component in Formula 7 is a mixture of any two or more (preferably 2 or 3) of the above-mentioned 6 species of bacteria (weight ratio is 1:1 or 1:1:1).

[0123] Mix milk and sugar according to the above formula ratio, stir until completely mixed, preheat, homogenize with 20Mpa pressure, sterilize at ab...

Embodiment 2

[0125] Pharmaceutical compositions containing probiotics of the Firmicutes class, such as Eubacterium inertus, Haldemannia fibriformis or combinations thereof

[0126] The ratio of raw materials is shown in Table 2.

[0127] Table 2 Pharmaceutical composition formula

[0128] raw material Mass percentage (%) Bacterial components 1.0％ lactose 2.0％ yeast 2.0％ Peptone 1.0％ pure water 94.0％

[0129] The bacterial components in formulas 1-6 are single bacterial components, which respectively contain Eubacterium siraeum DSM15702, Eubacterium siraeum 70 / 3, Eubacterium siraeum V10Sc8a, Holdemania filiformis DSM 12042, Holdemania filiformis VPI J1-37, Holdemania filiformis VPI S4B-1.

[0130] The bacterial component in Formula 7 is a mixture of any two or more (preferably 2 or 3) of the above-mentioned 6 species of bacteria (weight ratio is 1:1 or 1:1:1).

[0131] Mix lactose, yeast powder, and peptone evenly with purified water according...

Embodiment 3

[0132] Embodiment 3 for the therapeutic effect of obese model mice

[0133] Experimental Materials:

[0134] Mice: C57BL / 6J male mice (purchased from Guangdong Provincial Medical Experimental Animal Center) were purchased, which were normally bred mice and were 6 weeks old. Mice were raised in the same environment and fed the same food.

[0135] 6 strains of Firmicutes probiotics were obtained from the preservation institution and preserved in Shenzhen Huada Gene Research Institute. At the same time, Lactobacillus plantarum (Lactobacillus plantarum) was selected from the General Microorganism Center (CGMCC) of the China Microbiological Culture Collection Management Committee (CGMCC), with the preservation number CGMCC No.8198, as the control group (LP group), and cultured in the MRS culture medium at 37 ° C. 24-48h.

[0136] Among them, the source information of the above-mentioned 6 strains of Firmicutes probiotics is shown in Table 3. All strains were identified by 16SrD...

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Abstract

The invention discloses application of thick-wall fungus probiotics to treatment and prevention of obesity and related diseases. Specifically, the thick-wall fungus probiotics are used for preparing a composition or preparation. The composition or preparation is used for one or more purposes of a, preventing and / or treating obesity; b, reducing blood fat; c, preventing or treating cardiovascular diseases; and / or d, preventing and / or treating diabetes. The thick-wall fungus probiotics can remarkably reduce weight, blood fat and body fat percentage.

Description

technical field [0001] The invention belongs to the field of microbiology. Specifically, the invention relates to the application of Firmicutes probiotics in the treatment and prevention of obesity and related diseases, and also relates to a composition containing Firmicutes probiotics and its application. Background technique [0002] There are a large number of symbiotic microorganisms in the human body, most of which live in the human intestinal tract, and the number exceeds 1000 trillion (10 14 Order of magnitude), more than 10 times the total number of human cells. During the long evolutionary process, intestinal microbes have reached a good cooperation with human beings, and play a vital role in the nutrition, metabolism and immunity of the human body. Many researchers regard the human intestinal microbiome as more It is an "organ" of the human body, or the second genome of the human body, and the massive genetic information contained in it is closely related to human...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/741A23L2/52A23L33/135A23C9/12A23K10/18A61P3/04A61P3/06A61P9/00A61P3/10
CPCA23C9/12A23L2/52A23V2002/00A61K35/741A61K2300/00A23V2200/332A23V2200/3262A23V2200/326A23V2200/328A23V2250/28A23V2250/5062Y02A50/30
Inventor 冯强张东亚
Owner SHENZHEN HUADA GENE INST
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