Preparation method of N-phenyl-N-[8]quinolyl-benzamide
A technology of benzamide and quinolinyl, which is applied in the field of preparation of N-phenyl-N-[8]quinolyl-benzamide, can solve the problems that the reaction conditions need to be improved, and achieve environmental friendliness and excellent reaction conditions. Gentle and economical effect
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[0008] In the present invention, benzoyl 8-aminoquinoline, anhydrous copper acetate, triphenylbismuth, sodium bicarbonate, 1,4-dioxane solvent and one No. 5 magnet are successively added into the reactor. Pass the condensed water through the condensing pipe from bottom to top, and place the reactor in an oil bath to heat the reaction. After the reaction, the reaction solution was poured into a separatory funnel, distilled water was added, and extracted three times with ethyl acetate. The obtained organic phases were combined and spin-dried by a rotary evaporator, and the crude product was separated and purified by column chromatography to obtain N-phenyl-N-[8]quinolyl-benzamide compounds.
[0009] The purity of described benzoyl 8-aminoquinoline is 98%, the purity of triphenyl bismuth is 98%, the purity of anhydrous copper acetate is 99%, the purity of sodium bicarbonate is 99.5%, 1,4-dioxo Hexacyclic has a purity of 99.5%.
[0010] The reactor is a micro reaction tube with ...
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