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Extraction technology and application of MagnolosideA

An extraction process and technology for extracting liquid, which is applied in the field of medicine and can solve problems such as cumbersome operations and complicated extraction and separation methods

Active Publication Date: 2017-08-04
INST OF PHARMACY SHANDONG PROV ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In this patent, the extraction and separation method of MagnolosideA is relatively complicated and the operation is cumbersome

Method used

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  • Extraction technology and application of MagnolosideA
  • Extraction technology and application of MagnolosideA
  • Extraction technology and application of MagnolosideA

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] MagnolosideA Extraction Separation:

[0056] Take 15 kg of dried bark magnolia bark as the original medicinal material, infiltrate it with 95% ethanol for two days, then extract it under reflux for 3 times, concentrate the extract under reduced pressure to obtain 1.5 kg of extract, add water to suspend it, mix the sample with 3 kg of silica gel, Put it on a silica gel column (200-300 mesh) after it is completely dry. 240 g of part A was eluted with petroleum ether-acetone, 130 g of part B was eluted with dichloromethane, 130 g of part C was eluted with dichloromethane: methanol (30:1), and 130 g of part C was eluted with dichloromethane: methanol (10:1) was eluted to obtain site D, and eluted with pure methanol to obtain site E. After thin-layer chromatography analysis, it was found that site D and site E had a high overlap, so the two sites were merged into site D' (440 g).

[0057] Separation and purification of D' site

[0058] Fully dissolve the D' part with pure ...

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Abstract

The invention belongs to the technical field of medicines and in particular relates to an extraction technology and application of MagnolosideA. The extraction technology comprises the following steps: carrying out ethanol extraction on a mangnolia officinalis medicinal material, and carrying out silica gel column elution separation, so that high-purity MagnolosideA is obtained. Experiments show that MagnolosideA has protective effect on gastric mucosal injury, caused by ethanol-aspirin of a rat and can be used for treating gastric ulcer. The application of MagnolosideA is disclosed for the first time.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a MagnolosideA extraction process and application thereof. Background technique [0002] Magnolia officinalis (Latin name: Magnolia officinalis Rehd. et Wils.) belongs to Magnolia (MagnoLiaceae) Magnolia (MagnoLia) plants, including concave leaf Magnolia officinalis subsp. biloba officinalis (original subspecies) M. officinalis subsp. officinalis Two kinds. According to Flora of my country, this plant is mainly distributed in the south, southeast and northeast of China; it is often found in mountainous forests at an altitude of 300-1400 meters. All parts of Magnolia officinalis can be used as medicine, mainly the bark, which is aromatized and damp-removing traditional Chinese medicine. It can be used to treat: food stagnation and stagnation of qi; abdominal distension and constipation; Now it is a national second-level key protected wild plant. [0003] Magnolia o...

Claims

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Application Information

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IPC IPC(8): C07H1/08C07H15/18A61P1/04
CPCC07H1/08C07H15/18
Inventor 姚庆强牟艳玲滕素玲李玲齐晓玲孙敬勇刘拥军李莹熊山
Owner INST OF PHARMACY SHANDONG PROV ACAD OF MEDICAL SCI