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Method for rapidly detecting volatile oil extraction process of preparation process of Qizhi Weitong granules with NIRS (near infrared spectroscopy) and application

A near-infrared spectroscopy and near-infrared spectroscopy technology, which is applied to measuring devices, material analysis through optical means, instruments, etc., can solve the problems of low efficiency, difficulty in reflecting the chemical and physical changes in the extraction process, and affecting production efficiency, etc. question

Inactive Publication Date: 2017-08-11
辽宁华润本溪三药有限公司
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Problems solved by technology

However, due to the low efficiency of traditional analysis methods, not only greatly affects the production efficiency, but also it is difficult to reflect the complex chemical and physical changes in the extraction process and concentration process

Method used

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  • Method for rapidly detecting volatile oil extraction process of preparation process of Qizhi Weitong granules with NIRS (near infrared spectroscopy) and application
  • Method for rapidly detecting volatile oil extraction process of preparation process of Qizhi Weitong granules with NIRS (near infrared spectroscopy) and application
  • Method for rapidly detecting volatile oil extraction process of preparation process of Qizhi Weitong granules with NIRS (near infrared spectroscopy) and application

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Embodiment 1

[0076] Example 1 Study on the extraction process of volatile oil in the preparation process of Qizhi Weitong Granules by near-infrared spectroscopy

[0077] 1. Instruments and reagents

[0078] 1.1 Main medicinal materials and reagents

[0079] Citrus aurantium and Rhizoma Cyperi (burnt), provided by Liaoning China Resources Benxi Sanyao Co., Ltd.; neohesperidin reference substance (Chengdu Master Biological Technology Co., Ltd., batch number: MUST-11030701); naringin reference substance (Chengdu Mansi Special Biotechnology Co., Ltd., batch number: MUST-11030612); acetonitrile (Merck, Germany); phosphoric acid (Aladdin); Wahaha purified water.

[0080] 1.2 Main instruments and equipment

[0081] Agilent1200 high-performance liquid chromatography (Agilent1200 pump, Agilent1200 photoelectric secondary array detector, Agilent1200 chromatographic workstation, Agilent Technologies, USA); Antaris Fourier transform near-infrared spectrometer (Thermo Nicolet, USA); equipped with a...

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Abstract

The invention relates to a method for rapidly detecting a volatile oil extraction process of a preparation process of Qizhi Weitong granules with NIRS (near infrared spectroscopy) and an application. An NIRS online analysis method for the volatile oil extraction process of the preparation process of the Qizhi Weitong granules is established and applied to online detection, so that automatic detection of the volatile oil extraction process of the preparation process of the Qizhi Weitong granules and real-time prediction of content of each quality control index are realized; an established model is high in prediction precision and accuracy and meets the requirement for quantitative analysis in actual production; compared with a traditional pharmacopeia method, the method has the advantages that on the premise that the accuracy is guaranteed, the analysis efficiency is increased greatly, the quality of the volatile oil extraction process of the preparation process can be monitored and controlled in real time rapidly and efficiently, and accordingly, guarantee of safety, stability and effectiveness of the quality of final products is facilitated.

Description

technical field [0001] The invention belongs to the field of drug detection, and specifically relates to a method and application for rapidly detecting the process of extracting volatile oil in the preparation process of Qi stagnation Weitong granules by using near-infrared spectroscopy. Background technique [0002] Qi stagnation stomach pain granules are made of 6 traditional Chinese medicines of Bupleurum, Corydalis Corydalis, Fructus Citrifolia, Cyperi Cyperi, Radix Paeoniae Alba and Radix Glycyrrhiza. The treatment of epigastric pain and other diseases has become the first-line drug for clinical treatment of epigastric pain after years of clinical practice. However, the preparation process of Qizhi Weitong Granules is complex and cumbersome, and slight changes in various process parameters in the actual production process may directly affect the quality of the final drug. [0003] Traditional drug analysis techniques generally use off-line analysis methods to collect l...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/359G01N30/02
CPCG01N21/359G01N30/02
Inventor 孟宪生何晓霞潘英韩凌包永睿王帅李天娇王颖
Owner 辽宁华润本溪三药有限公司
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