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Animal blood temperature lowering method and application thereof and cardiopulmonary resuscitation low temperature animal model preparing method and animal model

A cardiopulmonary resuscitation and animal model technology, applied in the medical field, can solve the problems of high cost, slow cooling speed, and poor effect, and achieve the effect of low cost, fast cooling speed, and simple operation

Inactive Publication Date: 2017-08-25
张茂 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The first object of the present invention is to provide a method for cooling animal blood, the second object of the present invention is to provide a method for preparing a hypothermic animal model of cardiopulmonary resuscitation, and the third object of the present invention is to provide a hypothermic animal model of cardiopulmonary resuscitation. The fourth purpose is to provide the application of the method for cooling animal blood, so as to alleviate the technical problems of slow animal cooling speed, poor effect and high cost in the prior art

Method used

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  • Animal blood temperature lowering method and application thereof and cardiopulmonary resuscitation low temperature animal model preparing method and animal model
  • Animal blood temperature lowering method and application thereof and cardiopulmonary resuscitation low temperature animal model preparing method and animal model
  • Animal blood temperature lowering method and application thereof and cardiopulmonary resuscitation low temperature animal model preparing method and animal model

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Embodiment 1

[0065] This embodiment provides a method for inducing animal blood cooling through the esophagus, including: after fixing the animal, the esophageal cooling catheter is externally connected to an ice blanket instrument, the esophageal cooling catheter is inserted into the esophagus of the animal, and the esophageal cooling catheter is perfused with a circulating low-temperature liquid at 4°C , through heat exchange between the 4°C liquid and the blood in the heart and large blood vessels adjacent to the esophagus, the purpose of rapid cooling is achieved.

[0066] Wherein, the 4°C liquid may be, for example, but not limited to: 4°C sterilized water for injection.

[0067] The esophageal cooling catheter used in Example 1 is as follows: figure 1 As shown, the esophageal cooling catheter includes a central part 1 and a helical part 2 that is attached to the central part 1 and spirally arranged. This arrangement ensures the maximum contact area between the esophageal cooling cath...

Embodiment 2

[0088] This embodiment provides a method for preparing a hypothermic animal model of cardiopulmonary resuscitation, including:

[0089] 1. Experimental animal preparation

[0090] 1) Before the experiment, the animals were fasted for 12 hours without water.

[0091] 2) During the experiment, anesthesia was induced by intramuscular injection of ketamine at 20 mg / kg, weighed, placed on the triangle of the operating table, fixed the limbs, and connected to the SPO 2 , ECG and rectal watch, dynamic monitoring of vital signs, and use temperature control blanket to maintain normal body temperature of animals at (38.0±0.5)℃ before induction of ventricular fibrillation.

[0092] 3) Establish ear vein channel, general anesthesia with pentobarbital sodium 30mg / kg intravenously, then maintain anesthesia state with pentobarbital sodium 8mg / (kg·h), and continue sedation with fentanyl 2μg / (kg·h) pain treatment.

[0093] 4) Orotracheal intubation, connected to ETCO 2 / SPO 2 Monitor and ve...

Embodiment 3

[0119] This example provides a method for cooling animal blood induced by CRRT, including: using CRRT to introduce venous blood to the outside of the body, and then placing the CRRT venous return line in 4°C liquid to realize blood and 4°C liquid passing through CRRT The pipeline performs rapid heat exchange, and then the low-temperature blood is returned to the body to achieve the purpose of rapid cooling.

[0120] Among them, CRRT parameter setting:

[0121] In CVVH mode, the blood flow rate is initially 180ml / min and maintained at 120ml / min, the rate of replacement fluid is 30ml / kg / h, dehydration is 0ml / kg / h, the first dose of heparin is injected statically at 1000U, and the micropump maintains at 150U / h.

[0122] CRRT liquid configuration:

[0123] Preflush: 1 tube of heparin, 1500ml of 0.9% NaCl solution.

[0124] Replacement solution: 1) A solution: 0.9% NaCl solution 2000ml, 5% Glu solution 100ml, 10% KCl solution 10ml, 10% calcium gluconate solution 13ml, 25% MgSO 4...

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Abstract

The invention provides an animal blood temperature lowering method and an application thereof and a cardiopulmonary resuscitation low temperature animal model preparing method and an animal model, and relates to the technical field of medicine. The animal blood temperature lowering method can achieve rapid cooling, simple operation, low cost and fast cooling speed by the heat exchange between liquid of 4 DEG C and animal blood. In addition, according to the animal model prepared by the cardiopulmonary resuscitation low temperature animal model preparing method, cardiopulmonary resuscitation and low temperature treatment schemes can be scientifically simulated; a study basis is provided for low temperature treatment related researches in cardiopulmonary resuscitation; the animal blood temperature lowering method is simple in operation, low in cost and fast in cooling speed, and can be used in the preparation of the cardiopulmonary resuscitation low temperature animal model.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to a method for cooling animal blood and its application, a method for preparing a low-temperature animal model of cardiopulmonary resuscitation, and the animal model. Background technique [0002] At present, common methods to reduce the body temperature of animals to the expected level include physical methods and chemical methods, such as using cooling blankets, ice caps, etc. to wrap animals to cool down, or injecting drugs such as chlorpromazine and promethazine to reduce the temperature. Effect of animal temperature. However, these cooling methods generally have a slow cooling rate and cannot achieve the desired effect well. [0003] In addition, although there are some rapid cooling methods, in general, most of them have disadvantages such as high cost, complicated operation, and trauma. [0004] Considering that therapeutic mild hypothermia has been proven to have an orga...

Claims

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Application Information

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IPC IPC(8): A61D7/00A61F7/12A61M1/36
CPCA61D7/00A61F7/12A61F2007/0001A61F2007/0056A61F2007/126A61M1/3612A61M1/369
Inventor 张茂徐杰丰
Owner 张茂
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