Ultra-fine powder ointment capable of relieving swelling and pain, and preparation method thereof

Abstract

The invention discloses an ultra-fine powder ointment capable of relieving swelling and pain, and a preparation method thereof. The ultra-fine powder ointment capable of relieving swelling and pain comprises a ultra-fine powder, one or two ingredients selected from borneol and menthol, and a plant oil ointment matrix; the ultra-fine powder is prepared from an ingredient A, or an ingredients B, or an mixture of the ingredient A and the ingredient B; the ingredient A is one or a mixture of a plurality of components selected from polygonum cuspidatum, rheum officinale, and rhizoma coptidis; the ingredient B is one or a mixture of a plurality of components selected from calcined gypsum, mirabilite, and calcined alumen. According to the preparation method, polygonum cuspidatum is smashed via a convention smashing method so as to obtain a powder 1 with a particle size of 60 to 80 meshes; calcined gypsum is smashed into a powder 2, and the powder 1 and the powder 2 are subjected to superfine grinding so as to obtain a mixed ultra-fine powder; the mixed ultra-fine powder, borneol, and the plant oil ointment matrix are uniformly mixed so as to obtain the ultra-fine powder ointment. The smashing degree of the ultra-fine powder ointment is higher; it is beneficial for dissolving and transdermal absorption of effective ingredients; drug dispersion uniformity is increased; the obtained ultra-fine powder ointment is stable and fine, is low in viscosity and yield stress, and better in ductility properties; low temperature material melting and drug adding technology is adopted, production technology is simplified, energy saving and consumption reduction are realized; and industrialized production is convenient to realize.

Description

technical field [0001] The invention relates to a superfine powder ointment with heat-clearing, detoxifying, swelling-reducing and analgesic effects and a preparation method thereof, belonging to the technical field of pharmacy. Background technique [0002] Sores refer to the general term of all body surface suppurative infectious diseases caused by various pathogenic factors invading the human body, including acute and chronic two categories. Sores and sores are mostly caused by the internal invasion of poisonous evil, and the scorching blood caused by evil heat, resulting in the stagnation of qi and blood. It includes swelling and ulcers on the body surface, carbuncle, gangrene, furuncle, furuncle, discharge, phlegm, scrofula and related skin diseases. It is the most common type of syndrome in surgical diseases of traditional Chinese medicine , has the characteristics of rapid onset and severe disease in some cases. The pathogenic factors of sores can be divided into tw...

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Problems solved by technology

[0007] However, the preparation method used in the patent CN101703580 A still has the following problems, which limit the production of the preparation and the exertion of the curative effect, and need to be solved urgently

① Polygonum cuspidatum is used as fine powder, the particle size of the medicinal material is large, the dissolution of active ingredients and transdermal absorption are insufficient, the utilization rate of the medicinal material is not high, and the particle size of the powder is uneven, the drug and the matrix are easy to separate after long-term storage, the paste has a strong sense of roughness, and it is difficult to deploy Smear; ②borneol is difficult to mechanically pulverize, easy to form cakes, and easy to sublimate. Add the fine powder directly to the oil and wax mixture at nearly 80°C, so that it is easy to escape and lose during the addition and storage, which will affect the curative effect; ③sesame oil, solid The paraffin wax melt needs to be heated until it turns blue smoke, and then the smoke clears, and the drug is added after the temperature drops to nearly 80°C. This high-temperature melt process consumes energy and does not meet the requirements of clean and energy-saving production, and the sesame oil is at the smoke point. (177°C) will decompose, easy to decompose and produce harmful substances

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