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Preparation method of copper sulphide/silicon dioxide doubly-weakened cadmium sulfide/carbon doped titanium dioxide insulin photoelectrochemical sensor

A technology of silicon dioxide and titanium dioxide, which is applied in the fields of electrochemical variables of materials, scientific instruments, instruments, etc., to achieve the effect of good biocompatibility, simple preparation method, and increased steric hindrance

Active Publication Date: 2017-09-01
上海佑科仪器仪表有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are no published reports about the strategy of copper sulfide / silica nanocomposite double attenuation of photocurrent signal for the detection of insulin sandwich photoelectrochemical immunosensor

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Example 1 Preparation method of copper sulfide / silicon dioxide double weakened cadmium sulfide / carbon doped titanium dioxide insulin photoelectrochemical sensor

[0047] (1) Preparation of carbon-doped titania nanoparticles

[0048] Dissolve 0.5 mL of tetra-n-butyl titanate in 40 mL of ethylene glycol, add dropwise to 40 mL of ultrapure water, stir with magnetic force for 30 min, conduct hydrothermal reaction at 180 °C for 6 h, cool down to room temperature, wash with ethanol and water for 3 times, vacuum drying at 60 °C for 12 h;

[0049] (2) Preparation of cadmium sulfide quantum dots

[0050] 250 µL of thioglycolic acid was added to 50 mL of 0.005 mol / L cadmium chloride solution, bubbled at 100 °C for 30 min under a nitrogen atmosphere, and the pH was maintained at 10, then 5.5 mL of 0.1 mol / L sodium sulfide was added, Reflux for 3 h;

[0051] (3) Preparation of photoelectrochemical sensors

[0052] 1) The 0.8 × 1.5 cm ITO electrode was ultrasonically cleaned wit...

Embodiment 2

[0060] Example 2 Preparation method of copper sulfide / silicon dioxide dual weakened cadmium sulfide / carbon doped titanium dioxide insulin photoelectrochemical sensor

[0061] (1) Preparation of carbon-doped titania nanoparticles

[0062] Dissolve 1 mL of tetra-n-butyl titanate in 40 mL of ethylene glycol, add dropwise to 40 mL of ultrapure water, stir with magnetic force for 30 min, react in hydrothermal reaction at 180 °C for 12 h, cool down to room temperature, wash with ethanol and water for 3 times, vacuum drying at 60 °C for 12 h;

[0063] (2) Preparation of cadmium sulfide quantum dots

[0064] 250 µL of thioglycolic acid was added to 50 mL of 0.01 mol / L cadmium chloride solution, bubbled at 110 °C for 30 min under a nitrogen atmosphere, and the pH was maintained at 11, then 5.5 mL of 0.1 mol / L sodium sulfide was added, Under reflux for 4 h;

[0065] (3) Preparation of photoelectrochemical sensors

[0066] 1) The 0.8 × 1.5 cm ITO electrode was ultrasonically cleaned ...

Embodiment 3

[0074] Example 3 Preparation method of copper sulfide / silicon dioxide double weakened cadmium sulfide / carbon doped titanium dioxide insulin photoelectrochemical sensor

[0075] (1) Preparation of carbon-doped titania nanoparticles

[0076] Dissolve 2 mL of tetra-n-butyl titanate in 40 mL of ethylene glycol, add dropwise to 40 mL of ultrapure water, stir with magnetic force for 30 min, conduct hydrothermal reaction at 180 °C for 24 h, cool down to room temperature, wash with ethanol and water for 3 times, vacuum drying at 60 °C for 12 h;

[0077] (2) Preparation of cadmium sulfide quantum dots

[0078] Add 250 µL thioglycolic acid to 50 mL, 0.02 mol / L cadmium chloride solution, bubble at 120 °C for 30 min under nitrogen atmosphere, keep pH = 12, then add 5.5 mL sodium sulfide with a concentration of 0.1 mol / L, nitrogen atmosphere Under reflux for 5 h;

[0079] (3) Preparation of photoelectrochemical sensors

[0080] 1) The 0.8 × 1.5 cm ITO electrode was ultrasonically clean...

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Abstract

The invention belongs to the fields of manometer functional materials, immunoassay and biosensing technique. The invention provides a preparation method of a copper sulphide / silicon dioxide doubly-weakened cadmium sulfide / carbon doped titanium dioxide insulin photoelectrochemical sensor. According to the method, the steric-hinerance effect of silicon dioxide as well as the competitive consumption effect of copper sulfide for electron donor ascorbic acid and the competitive absorption effect of copper sulfide for an excitation light source are specifically adopted, and photo-signals generated by a substrate cadmium sulfide / carbon doped titanium dioxide sensitization structure are doubly weakened, so that high sensitivity detection for insulin is realized. The method has the advantages of simple preparation, low cost, quick detection, high sensitivity and easy microminiaturization.

Description

technical field [0001] The invention relates to a preparation method of copper sulfide / silicon dioxide double weakened cadmium sulfide / carbon doped titanium dioxide insulin photoelectrochemical sensor. Specifically, copper sulfide / silicon dioxide nanocomposite materials are used to double reduce the photocurrent signal of cadmium sulfide-sensitized carbon-doped titanium dioxide to prepare a highly sensitive photoelectrochemical sensor for insulin detection, which belongs to new functional materials and biosensing technology. detection field. Background technique [0002] Insulin is a polypeptide hormone that plays an important role in regulating carbohydrate and blood sugar levels in the body. It is the only hormone that lowers blood sugar in the body. Insufficient secretion of insulin in the human body or obstacles to its utilization by the body will lead to the occurrence of diabetes. With the increasing incidence of diabetes year by year, it is of great significance for...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/26G01N27/327G01N33/543
CPCG01N27/26G01N27/3278G01N33/54366
Inventor 王雪萍魏琴马洪敏吴丹张勇孙旭闫涛匡轩
Owner 上海佑科仪器仪表有限公司
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