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Gnaphalium affine extract, gnaphalium affine active substance enriched product, preparation method and application

A technology of sagebrush and its extract, which is applied in the field of sagebuckle extract, can solve the problem of not being able to reduce the total amount of uric acid in the body, and achieve the effects of small toxic and side effects, significant drug efficacy, and rich wild resources

Active Publication Date: 2017-09-05
SHANGHAI INST OF PHARMA IND CO LTD +1
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  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

From the perspective of the mechanism of disease relief, inhibiting the production of uric acid cannot effectively reduce the total amount of uric acid in the body from the source, especially when the total amount of uric acid is already at a high level, the drug that inhibits the production of uric acid is not an ideal solution, so looking for An ideal natural drug extract that promotes uric acid excretion is a problem to be solved. Finally, the present invention solves the above-mentioned technical problems through the following technical solutions

Method used

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  • Gnaphalium affine extract, gnaphalium affine active substance enriched product, preparation method and application
  • Gnaphalium affine extract, gnaphalium affine active substance enriched product, preparation method and application
  • Gnaphalium affine extract, gnaphalium affine active substance enriched product, preparation method and application

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Embodiment 1

[0035]After drying in the shade, cut Sageweed into sections, weigh 1kg, mix with 15L (1:15, kg / L) of 60% (v / v) ethanol aqueous solution, heat and reflux for extraction twice, each time for 1h, and combine the extracts. The extract was concentrated under reduced pressure (60°C) and dried to obtain 166.4 g of Sage Herb Extract.

Embodiment 2

[0037] After drying in the shade, cut sagegrass into sections, weigh 5kg, mix with 50% (v / v) ethanol aqueous solution 50L (1:10, kg / L, ratio, heat and reflux for 3 times, each time for 2h, and combine the extracts. The solution was concentrated under reduced pressure (70° C.), and dried to obtain 982.2 g of sage extract.

Embodiment 3

[0039] After drying in the shade, cut Sageweed into sections, weigh 2kg, mix with 40L (1:20, kg / L) of 80% (v / v) ethanol aqueous solution, heat and reflux for extraction 4 times, each time for 2h, and combine the extracts. The extract was concentrated under reduced pressure (50°C) and dried to obtain 311.6 g of Sage Herb Extract.

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Abstract

The invention discloses a gnaphalium affine extract, a gnaphalium affine active substance enriched product, a preparation method and application. The preparation method of the gnaphalium affine extract comprises the following steps: mixing gnaphalium affine with ethanol water, mixing and extracting to obtain an extracting solution which is the final product. The volume percentage of the ethanol water is 50-80%. By the gnaphalium affine extract and the gnaphalium affine active substance enriched product, urate excretion can be promoted, the effect is stable, furthermore, the urea nitrogen level can further be reduced by the gnaphalium affine active substance enriched product, and acute kidney injury caused by uric acid is protected to a certain degree; and gnaphalium affine wild resources are abundant, the cost of medicinal materials is low, and the developing potential is huge.

Description

technical field [0001] The present invention relates to an extract of sage galenia, an enrichment of active substances of sage sage, a preparation method and an application. Background technique [0002] Uric acid is the final metabolite of human purine compounds, and disorders of purine metabolism can lead to hyperuricemia. Hyperuricemia (HUA) refers to the level of blood uric acid on an empty stomach that is higher than 420 μmol / L for men and higher than 360 μmol / L for women under a normal purine diet. Hyperuricemia is caused by increased production or decreased excretion of uric acid in the body. Hyperuricemia is the basis of gout. When the concentration of uric acid is supersaturated to form crystals and deposit in the joint synovium, soft tissue, cartilage and kidneys, it will cause "gout", which triggers the body's innate immune response, causing joints and their surroundings Tissue inflammation and renal impairment. In patients with hyperuricemia, the metabolic fun...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/28A61P19/06A23L33/00
CPCA23V2002/00A61K36/28A61K2236/333A61K2236/39A61K2236/55A23V2200/30A23V2250/21
Inventor 范思洋吴春珍张伟
Owner SHANGHAI INST OF PHARMA IND CO LTD
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