Multi-stimulus-response cross-linked polymer nano-hydrogel, method for preparing same and application of multi-stimulus-response cross-linked polymer nano-hydrogel
A multi-stimulus-responsive, nano-hydrogel technology, applied in the field of biomedicine, to achieve the effect of clear and concise preparation process, excellent degradable performance, and good comprehensiveness
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Embodiment 1
[0028] Add 20g of polyethylene glycol diglycidyl ether (Mn=200) and 6g of anhydrous piperazine to 60ml of ethanol, and reflux for 6 hours under magnetic stirring at 60°C; then add 3.8g of cystamine to the reactant solution and continue to reflux React for 12 hours; after the reaction, precipitate the reaction mixture in methanol, then filter, wash the product three times with methanol, and dry it in vacuum at 50° C. for 24 hours to obtain nano hydrogel particles.
Embodiment 2
[0030] Add 20g of polyethylene glycol diglycidyl ether (Mn=2000) and 0.4g of anhydrous piperazine to 206ml of ethanol, and reflux reaction under magnetic stirring at 80°C for 24 hours; then add 0.19g of cystamine to the reactant solution to continue Reflux reaction for 24 hours; after the reaction, the reaction mixture was precipitated in methanol, then filtered, the product was repeatedly washed with methanol three times, and vacuum-dried at 50° C. for 10 hours to obtain nano hydrogel particles.
Embodiment 3
[0032] Add 20g of polypropylene glycol diglycidyl ether (Mn=200) and 3g of propylamine to 60ml of ethanol, and reflux for 12 hours under magnetic stirring at 70°C; then add 2g of cystamine to the reactant solution and continue to reflux for 18 hours; the reaction is over Finally, the reaction mixture was precipitated in methanol, and then filtered, and the product was repeatedly washed with methanol three times, and dried in vacuum at 30° C. for 24 hours to obtain nano hydrogel particles.
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