Pressurized filtration system and method for glycosylated hemoglobin analyzer

Abstract

The invention discloses a pressurized filtration system for a glycosylated hemoglobin analyzer. The pressurized filtration system comprises the glycosylated hemoglobin analyzer, the glycosylated hemoglobin analyzer is provided with a sampling mechanism, a chromatography column and a colorimetric pool which are connected through a pipeline in series, the tail end of the pipeline is sequentially connected with a micro-particle and fiber protein filter and a turbocharger in series, and the turbocharger is provided with spirally wound pipe segments; the filter is provided with a disc-shaped filter body, an inlet and an outlet are form in the two ends of the filter body respectively, the filter body is filled with a round-cake shaped filter core, and the filter core is formed by adopting hydrophobic UHMW-PE to be sintered after being subjected to surface modification by a hydrophilic water agent. According to the pressurized filtration system for the glycosylated hemoglobin analyzer, the turbocharger is utilized to inhibit bubbles, at the same time, the blockage of a turbocharger spiral tube is avoided through the adoption of the filter, the reliability of a miniature glycosylated hemoglobin monitoring apparatus is improved, and the maintenance-free cycle of the miniature glycosylated hemoglobin monitoring apparatus is prolonged.

Description

Technical field [0001] The invention relates to the technical field of medical biochemical detection equipment, in particular to a pressurized filtration system and method for a glycosylated hemoglobin analyzer. Background technique [0002] At present, the determination of glycosylated hemoglobin mainly uses ion exchange chromatography, the principle of which is based on the loss of cations on the molecular surface after hemoglobin glycation. When the sample containing glycated hemoglobin passes through the cation exchange chromatography column, both the glycated hemoglobin and non-glycated hemoglobin are adsorbed by the cation exchange resin. The applicant has obtained a number of invention patents in the field of glycosylated hemoglobin analyzer, such as ZL201110084781.3 four-gradient elution analysis method for glycosylated hemoglobin analyzer, ZL201110100181.1 glycosylated hemoglobin analyzer backwash flow path system, etc. It solves the problems of miniaturization, reliabi...

AI Technical Summary

Problems solved by technology

During the measurement and elution process of the glycosylated hemoglobin analyzer, in order to avoid the bubbles generated in the optical colorimetric cell due to the small pressure value in the conventional liquid path, and to overcome the influence of the absorbance caused by the bubbles, a booster is connected in series at the end of the liquid path , the supercharger has a special screw extrusion structure, which uses back pressure to avoid the formation of air bubbles, but there are proteins, impurities, eluent dry crystals, etc. in the sample after entering the supercharger, which are easily adsorbed on the supercharger On the pipe wall, if it is not cleaned in time, it will easily cause blockage. Once the supercharger is blocked, it will be scrapped directly

It is also very difficult to regularly inspect and maintain the supercharger. On the one hand, the diameter of the supercharger is very small; Supercharger for daily maintenance and maintenance

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