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Absorbable suture thread and making method thereof

A suture thread and silk thread technology, applied in coating, medical science, surgery, etc., can solve the problems of large side effects, etc., and achieve the effect of small side effects, simple preparation process, and good antibacterial performance

Inactive Publication Date: 2017-09-29
WUHAN YIJIABAO BIOMATERIAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, injection or oral antibiotic drugs are often used clinically, resulting in great side effects on the body.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment example 1

[0024] 1 Spinning polyglycolic acid (PGA) on a self-made small spinning machine, controlling the spinning temperature to 240°C and spinning speed 100 m / min.

[0025] 2 The specific steps of chitosan coating are as follows: (1) Prepare 1% acetic acid solution, weigh an appropriate amount of chitosan (DD=90%), and prepare chitosan according to the mass ratio of chitosan: acetic acid solution = 1:100 Sugar solution; (2) Pour the chitosan solution into the dipping tank, and immerse the guide roller, the prepared PGA thread is immersed and pulled on the coating machine, and the speed of the thread passing through the chitosan solution is controlled and dried at low temperature. PGA silk thread coated with chitosan is needed.

[0026] 3 Disperse calcium stearate with the same quality as PGA in absolute ethanol and add it to PGA dissolved in hexafluoroisopropanol, and ultrasonically shake for 2 h until calcium stearate and PGA are evenly mixed to obtain a coating liquid; Pour the uniform...

Embodiment example 2

[0029] 1 Spinning polyglycolic acid (PGA) on a self-made small spinning machine, controlling the spinning temperature to 255°C and spinning speed 100 m / min.

[0030] 2 The specific steps of chitosan coating are as follows: (1) Prepare 1% acetic acid solution, weigh an appropriate amount of chitosan (DD=90%), and prepare chitosan according to the mass ratio of chitosan: acetic acid solution = 1:100 Sugar solution; (2) Pour the chitosan solution into the dipping tank, and immerse the guide roller, the prepared PGA thread is immersed and pulled on the coating machine, and the speed of the thread passing through the chitosan solution is controlled and dried at low temperature. PGA silk thread coated with chitosan is needed.

[0031] 3 Disperse calcium stearate with the same quality as PGA in absolute ethanol and add it to PGA dissolved in hexafluoroisopropanol, and ultrasonically shake for 2 h until calcium stearate and PGA are evenly mixed to obtain a coating liquid; Pour the uniform...

Embodiment example 3

[0034] 1 Spinning polyglycolic acid (PGA) on a self-made small spinning machine, controlling the spinning temperature to 240°C and spinning speed 100 m / min.

[0035] 2 The specific steps of chitosan coating are as follows: (1) Prepare 1% acetic acid solution, weigh an appropriate amount of chitosan (DD=90%), and prepare chitosan according to the mass ratio of chitosan: acetic acid solution = 1:100 Sugar solution; (2) Pour the chitosan solution into the dipping tank, and immerse the guide roller, the prepared PGA thread is immersed and pulled on the coating machine, and the speed of the thread passing through the chitosan solution is controlled and dried at low temperature. PGA silk thread coated with chitosan is needed.

[0036] 3 Disperse calcium stearate with a mass ratio of 2:1 to PGA in absolute ethanol and add it to the PGA dissolved in hexafluoroisopropanol, and vibrate ultrasonically for 2 hours until the calcium stearate and PGA are evenly mixed to obtain a coating Liquid;...

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Abstract

The invention relates to an absorbable suture thread and a making method thereof. The suture line is composed of polyglycolic acid (PGA), calcium stearate and chitosan, and has a good tensile strength and antibacterial property. The making method comprises the following steps: spinning the polyglycolic acid on a self-made small spinning machine to make PGA threads; preparing a chitosan solution having a certain concentration, and coating the PGA threads with chitosan in a coating machine; mixing and dissolving calcium stearate and the PGA to obtain a coating solution, and coating the chitosan-coated PGA threads in the coating machine; and finally carrying out plying braiding the PGA threads in a vertical spindle braiding machine to make the absorbent suture thread. The making method is simple, and can realize mechanical large-scale production. The produced absorbable suture thread has a good tensile strength and an antibacterial property, and can meet the needs of wound surgical suture.

Description

Technical field [0001] The invention relates to the field of medical biological materials, in particular to an absorbable suture thread and a preparation method thereof. Background technique [0002] Biodegradable polymer materials occupies an important position in the research and development of medical polymer materials, and have been applied in the fields of surgical sutures, bone repair engineering, and controlled drug release. The bioabsorbable suture was originally used as a catgut made of pure collagen fibers obtained after removing impurities from the intestinal mucosa of sheep or cattle. The initial elasticity of the suture is small, the smoothness is excellent, and the stability of the nodule is good. But its composition is uneven, the biological reaction is strong, the decomposition rate is too fast, and the absorption is unstable. [0003] Polyglycolic acid (PGA) is the linear aliphatic polyester with the simplest structure and the earliest commercialized species of ab...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L17/12A61L17/14
CPCA61L17/12A61L17/145A61L2420/02A61L2420/08C08L5/08
Inventor 柯林松雷勇唐小雄
Owner WUHAN YIJIABAO BIOMATERIAL CO LTD
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