Giant salamander secretion hydrogel and its preparation method and application

Abstract

The invention discloses an andrias davidianus secretion hydrogel, and a preparation method and an application thereof. Raw materials of the andrias davidianus secretion hydrogel comprise andrias davidianus secretions, acetic acid or an acetic acid solution, an alginate, and a solvent. Acetic acid small molecules can break interchain and intrachain ionic complexation and hydrogen bonds of an andrias davidianus secretion protein, and when the alginate is added, a cross-linked network is formed in short time through ionic complexation of amino groups from the protein chains and carboxylic groups from the alginate, so that the andrias davidianus secretion hydrogel still having good adhesion property in water is obtained. The andrias davidianus secretion hydrogel also has good self-healing ability, and can be extensively used for biological adhesives and preparation of medicines for treating wounds.

Description

technical field

[0001] The invention relates to the field of biological materials, in particular to a giant salamander secretion hydrogel and a preparation method and application thereof. Background technique

[0002] Amphibians are exposed to a wide variety of environments, and their unique skin plays a key role in their physiological regulation. Their skin secretions are rich in bioactive substances and have been extensively explored as a great wealth of drug candidates for analgesia, antibiotics, wound healing, antidiabetic, antiviral, anticancer and cardiovascular treatments. However, to date, few studies have focused on the preparation of amphibian skin secretions for biomaterial applications, despite increasing research on their unique and intrinsic biological activities.

[0003] The giant salamander, also known as the "Chinese giant salamander", belongs to the giant salamander family and is one of the largest extant amphibian species and a famous "living fossil", wh...

Images