Regulating method and device of three-dimensional light field between dual-layer biological scatter tissue
A technology of biological tissue and scattered light, applied in the field of bio-optics, to achieve the effect of simple device and low cost
Active Publication Date: 2017-10-27
SHANGHAI INST OF OPTICS & FINE MECHANICS CHINESE ACAD OF SCI
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The disadvantage is that a camera needs to be implanted behind the scattering sample during the scattering matrix calibration stage, so it is invasive
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[0030] The present invention will be further described below by embodiment, but should not limit protection scope of the present invention with this.
[0031] see first image 3 , image 3It is the light path diagram of the three-dimensional light field regulating device between double-layer biological scattering tissues of the present invention. As can be seen from the figure, the present invention realizes a three-dimensional optical field control device between double-layer biological scattering tissues, including a laser 1, and along the output light direction of the laser 1 are a spatial filter 2, a first mirror 3 and an adjustable beam splitting ratio. A beam splitter 4, the beam splitter 4 divides the incident light into a sample optical path 5 and a reference optical path 6, and the sample optical path 5 is sequentially composed of a half-wave plate 501, a second mirror 502, a phase delayer 503, a converging Optical lens 504, biological sample 7) first imaging lens 5...
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The invention provides a regulating method and device of a three-dimensional light field between dual-layer biological scatter tissue. The method comprises the steps that firstly, a laser beam is focused on the first-layer biological scatter tissue so as to form a point light source, and a wavefront distribution of spherical waves on the second-layer biological scatter tissue is calculated, wherein the spherical waves are emitted by the point light source; secondly, a interference pattern of scattered light and a beam of plane light is recorded by using a camera, wherein the scattered light is emitted through the second-layer biological scatter tissue; thirdly, the wavefront distribution information of the scattered light is extracted by using a computer from the interference pattern, and the phase conjugation wavefront distribution of the scattered light is obtained; fourthly, the wavefront distribution of the scattered light on the surface of the second-layer biological scatter tissue is calculated; fifthly, the wavefront distributions are superposed to form a synthesized wavefront distribution, and the synthesized wavefront distribution is loaded to a spatial light modulator, the spatial light modulator modulates the plane light in the second step and reflects the plane light to the second-layer biological tissue. According to the regulating method and device, the regulation on the light field between the dual-layer biological scatter tissue can be achieved, and the regulating method and device have the advantages of achieving the limit precision of optical diffraction, being noninvasive and achieving three-dimensional regulation.
Description
technical field [0001] The method belongs to the field of bio-optics, in particular a method and device for regulating a three-dimensional light field between double-layer biological scattering tissues. Background technique [0002] The time-reversal ultrasound-assisted optical focusing method can converge coherent light into the biological scatterer to form a high-brightness optical focus, which can be used for laser surgery, scanning imaging, photothermotherapy and optogenetics research. The principle of the method is as figure 1 As shown: the sample light S passes through two acousto-optic modulators (AOM1 and AOM2) and then undergoes a frequency shift. After irradiating the sample, it is scattered, and a beam of focused ultrasonic waves is injected from the side of the sample, and the frequency of the scattered light located in the ultrasonic focus is modulated by the ultrasonic wave. , the modulated light interferes with a beam of reference light R of the same frequenc...
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IPC IPC(8): G02F1/01G06F17/14G06F17/50
CPCG02F1/0121G02F1/0136G06F17/14G06F30/20
Inventor 乔木刘红林韩申生
Owner SHANGHAI INST OF OPTICS & FINE MECHANICS CHINESE ACAD OF SCI