Dehydroabietic-acid-based dipeptide surfactant and performance thereof
A surfactant, abietic acid-based technology, applied in the field of synthesis and application of natural product surfactants, can solve problems such as rosin resin acid molecules being easily oxidized
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Embodiment 1
[0026] Example 1: Synthesis of Compound 1: Dissolve 6-aminocaproic acid methyl ester hydrochloride (32.7g, 0.18mol) in dichloromethane, add triethylamine (72.8g, 0.72mol), 4-di Methylaminopyridine (DMAP) (0.8g, 0.006mol) and dehydroabietic acid (48g, 0.16mol), then add 2-(7-benzotriazole oxide)-N,N,N',N'- Tetramethyluronium hexafluorophosphate (HATU) (76.0g, 0.20mol), the temperature was raised to 35°C, and reacted for 5h. After the reaction, extract with dichloromethane, wash the organic layer with deionized water for 5-6 times, and wash with anhydrous Na 2 SO 4 dry. After suction filtration, dichloromethane was removed by rotary evaporation. The product was purified by column chromatography (eluent: petroleum ether: ethyl acetate = 2:1) to obtain a colorless viscous liquid.
Embodiment 2
[0027] Example 2: Synthesis of R-6: Add NaOH (5.2g, 0.13mol) and 200mL of ethanol to a 500mL single-necked bottle, stir until NaOH is completely dissolved, then add compound 1 (47.0g, 0.11mol), and heat up to 70°C, react for 1.5h. After the reaction was completed, it was cooled to room temperature, a solid was precipitated, and R-6 was obtained by suction filtration.
Embodiment 3
[0028] Example 3: Synthesis of Compound 2: Dissolve R-6 (38.3g, 0.088mol) in water, add dilute HCl to make the solution acidic, extract with ethyl acetate, wash the organic layer with deionized water 5-6 times and use Anhydrous MgSO 4 After drying and suction filtration, ethyl acetate was removed by rotary evaporation to obtain compound 2.
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