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Preparation method of grafted modified xanthan gum nano micro-gel

A technology of graft modification and xanthan gum, which is applied in the direction of non-active ingredient medical preparations, medical preparations containing active ingredients, and pharmaceutical formulas, etc., which can solve the problem of poor use effect, uncontrollable drug release rate, lack of Solve the specific binding of tumor cells and other problems, achieve the effect of convenient post-processing, excellent anti-protein adsorption effect, and prolong circulation time

Active Publication Date: 2017-11-03
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the release of drugs by traditional nano-scale drug carriers is generally only controlled by diffusion, and the drug release rate is uncontrollable, and lacks specific binding to tumor cells. In vivo, it can only rely on the EPR effect of tumor tissues to concentrate in lesions. Poor use of the

Method used

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  • Preparation method of grafted modified xanthan gum nano micro-gel
  • Preparation method of grafted modified xanthan gum nano micro-gel
  • Preparation method of grafted modified xanthan gum nano micro-gel

Examples

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Effect test

Embodiment 1

[0032] 1-1) Synthesis of N,N-bis(acryloyl)cystamine:

[0033] Dissolve 4.5g of cystamine hydrochloride in 25mL of deionized water, and stir in an ice-water bath for 30min; dissolve 3.6g of acryloyl chloride in 5mL of dichloromethane, and dissolve 3.2g of NaOH in 10mL of deionized water; Add acryloyl chloride solution and NaOH solution dropwise, keep stirring in an ice-water bath for 5 hours after the dropwise addition, and wash the white solid with 50mL ultrapure water three times, then recrystallize it with ethyl acetate and dry it in a vacuum oven at 30°C until constant Heavy, the white product was sealed and stored;

[0034] 1-2) Synthesis of grafted modified xanthan polymer and preparation of nano-microgel:

[0035] Add 100mL of deionized water into a 250mL three-necked flask, add 1g of xanthan gum into the three-necked flask under mechanical stirring, after it is completely dissolved, pass nitrogen gas for 30min, then raise the temperature to 60°C, and drop 0.106g of an ...

Embodiment 2

[0039] Configure an aqueous solution of xanthan gum as in Example 1-2), add dropwise an aqueous solution of 0.183g cerium ammonium nitrate to the xanthan gum solution, stir and oxidize for 30min, then add an aqueous solution of 5g AMPS and 0.100g N,N-bis(acryloyl ) the dichloromethane solution of cystamine, after the reaction is completed, the post-treatment method obtains the graft modified xanthan gum polymer sample and the graft modified xanthan gum nano microgel aqueous solution as in embodiment 1-2), and then According to the preparation method in Example 1-3), a drug-loaded graft modified xanthan gum nano-microgel solution was obtained to obtain S2.

Embodiment 3

[0041] Configure the xanthan gum aqueous solution as in Example 1-2), add dropwise the aqueous solution of 0.259g cerium ammonium nitrate to the xanthan gum solution, add the aqueous solution of 7.500g AMPS and 0.150g N,N-bis(propylene) after stirring and oxidizing for 30min Acyl) the dichloromethane solution of cystamine, after reaction is finished, obtain graft modified xanthan gum polymer sample and graft modified xanthan gum nano microgel aqueous solution as embodiment 1-2) aftertreatment method, Then according to the preparation method in Example 1-3), a drug-loaded graft modified xanthan gum nano-microgel solution was obtained to obtain S3.

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Abstract

The invention relates to the technical field of biomedical materials, in particular to a preparation method of grafted modified xanthan gum nano micro-gel. The preparation method comprises the following steps: firstly preparing N,N-bis-(acryloyl) cystamine; then performing graft polymerization and cross-linking reaction on xanthan gum, 2-acrylamide-2-methylpropanesulfonic acid and the N,N-bis-(acryloyl) cystamine to prepare a grafted modified xanthan gum polymer; and forming the polymer nano micro-gel in an aqueous solution. The 2-acrylamide-2-methylpropanesulfonic acid is graft-polymerized on the xanthan gum, so that the drug loading capability of the xanthan gum nano micro-gel can be increased; and through introducing of a disulfide bond, the nano micro-gel is endowed with reduction sensitivity. The nano micro-gel provided by the invention is high in biological compatibility, can be degraded in a body and is expected to be used as the anti-cancer drug carrier and to be applied for release control.

Description

technical field [0001] The invention relates to a preparation method of graft-modified xanthan gum nano-microgel, which belongs to the technical field of modification of natural polymer materials. Background technique [0002] Malignant tumors are one of the major diseases that threaten human life and health. At present, surgical treatment, traditional Chinese medicine conditioning, radiotherapy and chemotherapy are usually used to treat such diseases. Although there are more than 90 anti-tumor drugs in clinical practice, most of them are Most of them have the disadvantages of short metabolic time, poor targeting and strong drug resistance of tumors. Compared with traditional small-molecule anti-tumor drugs, the combination of nano-scale carriers and drug molecules can enhance drug stability, prolong the circulation time of drugs in the body, and reduce their damage to normal tissues. However, the release of drugs by traditional nano-scale drug carriers is generally only co...

Claims

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Application Information

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IPC IPC(8): C08F251/00C08F222/38C08F220/58A61K9/107A61K47/36A61K31/704A61P35/00
CPCA61K9/0019A61K9/1075A61K31/704A61K47/36C08F251/00C08F220/585
Inventor 徐杰倪才华张丽萍石刚桑欣欣
Owner JIANGNAN UNIV
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